Q9H4A3 | WNK1_HUMAN | Serine/threonine-protein kinase WNK1 (WNK1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 226~479 | |
| PF12202 | OSR1_C - Oxidative-stress-responsive kinase 1 C-terminal domain | 500~563 | |
| PF24889 | CCTL2_WNK - WNK CCTL2 domain | 1118~1192 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4088706 |  |
IC50 | = | 4.0 | nM | 462.41 | CNc1nc(-c2cc(C(=O)N3CCN(Cc4ccc(Cl)cc4)CC3)c(Cl)cn2)cs1 | Homo sapiens | CHEMBL4041133 | assay format |
| CHEMBL4098876 |  |
IC50 | = | 6.0 | nM | 465.42 | [2H]C([2H])([2H])Nc1nc(-c2cc(C(=O)N3CCN(Cc4ccc(Cl)cc4)CC3)c(Cl)cn2)cs1 | Homo sapiens | CHEMBL4041133 | assay format |
| CHEMBL4091128 |  |
IC50 | = | 39.0 | nM | 443.57 | COc1cccc(-c2cc(-n3cc(CNCC4CCCCC4)c4ccc(F)cc43)ccn2)c1 | Homo sapiens | CHEMBL4041133 | assay format |
| CHEMBL4065531 |  |
IC50 | = | 60.0 | nM | 425.58 | COc1cccc(-c2cc(-n3cc(CNCC4CCCCC4)c4ccccc43)ccn2)c1 | Homo sapiens | CHEMBL4041133 | assay format |
| CHEMBL4070177 |  |
IC50 | = | 95.0 | nM | 399.54 | COc1cccc(-c2cc(-n3cc(CNCC(C)C)c4ccccc43)c(C)cn2)c1 | Homo sapiens | CHEMBL4041133 | assay format |
| CHEMBL4060478 |  |
IC50 | = | 106.0 | nM | 427.96 | CNc1nc(-c2cc(C(=O)N3CCN(Cc4ccc(Cl)cc4)CC3)ccn2)cs1 | Homo sapiens | CHEMBL4041133 | assay format |
| CHEMBL4087727 |  |
IC50 | = | 162.0 | nM | 424.59 | COc1cccc(-c2cccc(-n3cc(CNCC4CCCCC4)c4ccccc43)c2)c1 | Homo sapiens | CHEMBL4041133 | assay format |
| CHEMBL4100485 |  |
IC50 | = | 420.0 | nM | 476.0 | CNc1nc(-c2ccc3c(c2)CCN3C(=O)c2ccccc2OCc2ccc(Cl)cc2)cs1 | Homo sapiens | CHEMBL4041133 | assay format |
| CHEMBL4070968 |  |
IC50 | = | 623.0 | nM | 437.54 | COc1cccc(-c2cc(C(=O)N3CCN(Cc4ccccc4)CC3)c3ccccc3n2)c1 | Homo sapiens | CHEMBL4041133 | assay format |
| CHEMBL4083340 |  |
IC50 | = | 750.0 | nM | 486.02 | COc1cccc(-c2cc(C(=O)N(C)[C@@H]3CCN(Cc4ccc(Cl)cc4)C3)c3ccccc3n2)c1 | Homo sapiens | CHEMBL4041133 | assay format |
| CHEMBL4061509 |  |
IC50 | = | 971.0 | nM | 421.93 | COc1cccc(-c2cc(C(=O)N3CCN(Cc4ccc(Cl)cc4)CC3)ccn2)c1 | Homo sapiens | CHEMBL4041133 | assay format |
| CHEMBL4087727 | |
Ki | = | 32.43 | nM | 424.59 | COc1cccc(-c2cccc(-n3cc(CNCC4CCCCC4)c4ccccc43)c2)c1 | Homo sapiens | CHEMBL4041141 | assay format |