Q9H3Y6 | SRMS_HUMAN | Tyrosine-protein kinase Srms (SRMS)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00017 | SH2 - SH2 domain | 120~197 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 232~480 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4108687 |  |
IC50 | = | 8.0 | nM | 565.56 | CC1(C)OC(=O)N2C[C@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)CC[C@H]21 | Homo sapiens | CHEMBL4727429 | single protein format |
| CHEMBL4106978 |  |
IC50 | = | 9.1 | nM | 535.53 | Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 | Homo sapiens | CHEMBL4727429 | single protein format |
| CHEMBL4749037 |  |
IC50 | = | 14.0 | nM | 537.5 | Nc1nccn2c([C@@H]3CC[C@H]4COC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 | Homo sapiens | CHEMBL4727429 | single protein format |
| CHEMBL4114929 |  |
IC50 | = | 16.0 | nM | 565.56 | COc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12 | Homo sapiens | CHEMBL4727429 | single protein format |
| CHEMBL4076024 |  |
IC50 | = | 19.0 | nM | 571.54 | COCC(=O)N1CCC[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)C1 | Homo sapiens | CHEMBL4057972 | single protein format |
| CHEMBL4103954 |  |
IC50 | = | 23.0 | nM | 581.57 | C[C@H]1CC[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)CN1C(=O)C1CC1 | Homo sapiens | CHEMBL4717049 | single protein format |
| CHEMBL4799627 |  |
IC50 | = | 24.0 | nM | 597.57 | CC1(C(=O)N2CCC[C@@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4F)c4c(N)nccn34)C2)COC1 | Homo sapiens | CHEMBL4717049 | single protein format |
| CHEMBL4094125 |  |
IC50 | = | 32.0 | nM | 579.58 | CC1(C(=O)N2CCC[C@@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)C2)COC1 | Homo sapiens | CHEMBL4717049 | single protein format |
| CHEMBL4077588 |  |
IC50 | = | 50.0 | nM | 583.59 | Nc1nccn2c([C@@H]3CCCN(C4CCOCC4)C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c12 | Homo sapiens | CHEMBL4057972 | single protein format |
| CHEMBL4107779 |  |
IC50 | = | 61.0 | nM | 591.59 | Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3OC3CC3)c12 | Homo sapiens | CHEMBL4727429 | single protein format |
| CHEMBL4060757 |  |
IC50 | = | 65.0 | nM | 585.56 | Nc1nccn2c([C@H]3CN(C4CCOCC4)CCO3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c12 | Homo sapiens | CHEMBL4057972 | single protein format |
| CHEMBL4062498 |  |
IC50 | = | 76.0 | nM | 573.51 | COCC(=O)N1CCO[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)C1 | Homo sapiens | CHEMBL4057972 | single protein format |
| CHEMBL4069387 |  |
IC50 | = | 84.0 | nM | 569.56 | CC(C)C(=O)N1CCC[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)C1 | Homo sapiens | CHEMBL4057972 | single protein format |
| CHEMBL4075954 |  |
IC50 | = | 103.0 | nM | 571.54 | CC(C)C(=O)N1CCO[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)C1 | Homo sapiens | CHEMBL4057972 | single protein format |
| CHEMBL4862806 |  |
IC50 | = | 114.0 | nM | 543.47 | Cc1ccc(C(=O)Nc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1C#Cc1cc(-c2cnn(C)c2)cnc1N | Homo sapiens | CHEMBL4839607 | single protein format |