Q9H3R0 | KDM4C_HUMAN | Lysine-specific demethylase 4C (KDM4C)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF02373 | JmjC - JmjC domain, hydroxylase | 177~293 | |
| PF02375 | JmjN - jmjN domain | 17~51 | |
| PF13831 | PHD_2 - PHD-finger | 712~747 | |
| PF13832 | zf-HC5HC2H_2 - PHD-zinc-finger like domain | 754~864 | |
| PF18104 | Tudor_2 - Jumonji domain-containing protein 2A Tudor domain | 882~916 | |
| PF18104 | Tudor_2 - Jumonji domain-containing protein 2A Tudor domain | 940~974 |
3D structures mapped by conservation among orthologs
[ Domain: "SH3" // LBR_tudor_1 ]
[ Domain: "Double-stranded beta-helix" // JmjC ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4225358 |  |
IC50 | = | 5.0 | nM | 295.3 | O=C(O)c1ccnc(-n2nccc2OCc2ccccc2)c1 | Homo sapiens | CHEMBL4223292 | single protein format |
| CHEMBL4211946 |  |
IC50 | = | 6.0 | nM | 312.37 | COc1ccc2c(c1)CCC[C@H]2CNc1cnccc1C(=O)O | Homo sapiens | CHEMBL4193838 | single protein format |
| CHEMBL4207583 |  |
IC50 | = | 8.0 | nM | 282.34 | O=C(O)c1ccncc1NC[C@@H]1CCCc2ccccc21 | Homo sapiens | CHEMBL4193838 | single protein format |
| CHEMBL1517074 |  |
IC50 | = | 8.0 | nM | 299.29 | COc1ccc(-c2nc3c(=O)n(C)c(=O)nc-3n(C)n2)cc1 | Homo sapiens | CHEMBL4610601 | single protein format |
| CHEMBL4648732 |  |
IC50 | = | 11.0 | nM | 294.27 | Cn1nc(-c2ccc(C#N)cc2)nc2c(=O)n(C)c(=O)nc1-2 | Homo sapiens | CHEMBL4610601 | single protein format |
| CHEMBL4204375 |  |
IC50 | = | 12.0 | nM | 282.34 | O=C(O)c1ccncc1NCC1CCCc2ccccc21 | Homo sapiens | CHEMBL4193838 | single protein format |
| CHEMBL4229271 |  |
IC50 | = | 14.0 | nM | 320.31 | N#Cc1ccc(COc2ccnn2-c2cc(C(=O)O)ccn2)cc1 | Homo sapiens | CHEMBL4223292 | single protein format |
| CHEMBL4646339 |  |
IC50 | = | 16.0 | nM | 312.33 | CN(C)c1ccccc1-c1nc2c(=O)n(C)c(=O)nc-2n(C)n1 | Homo sapiens | CHEMBL4610601 | single protein format |
| CHEMBL4207071 |  |
IC50 | = | 17.0 | nM | 374.44 | O=C(O)c1ccncc1NC[C@@H]1CCCc2cc(Oc3ccccc3)ccc21 | Homo sapiens | CHEMBL4193838 | single protein format |
| CHEMBL4228806 |  |
IC50 | = | 19.0 | nM | 384.41 | CN(C)CCc1cnn(-c2cc(C(=O)O)ccn2)c1OCc1ccc(F)cc1 | Homo sapiens | CHEMBL4223292 | single protein format |
| CHEMBL1316847 |  |
IC50 | = | 19.0 | nM | 270.25 | Cn1nc(-c2ccncc2)nc2c(=O)n(C)c(=O)nc1-2 | Homo sapiens | CHEMBL4610601 | single protein format |
| CHEMBL4225013 |  |
IC50 | = | 24.0 | nM | 313.29 | O=C(O)c1ccnc(-n2nccc2OCc2ccc(F)cc2)c1 | Homo sapiens | CHEMBL4223292 | single protein format |
| CHEMBL1394266 |  |
IC50 | = | 29.0 | nM | 283.29 | Cn1nc(Cc2ccccc2)nc2c(=O)n(C)c(=O)nc1-2 | Homo sapiens | CHEMBL4610601 | single protein format |
| CHEMBL4216044 |  |
IC50 | = | 35.0 | nM | 387.48 | CN(c1ccccc1)c1ccc2c(c1)CCC[C@H]2CNc1cnccc1C(=O)O | Homo sapiens | CHEMBL4193838 | single protein format |
| CHEMBL4228292 |  |
IC50 | = | 38.0 | nM | 359.77 | COc1cc(Cl)ccc1COc1ccnn1-c1cc(C(=O)O)ccn1 | Homo sapiens | CHEMBL4223292 | single protein format |
| CHEMBL4640696 |  |
IC50 | = | 42.0 | nM | 348.34 | Cn1nc(-c2ccc(S(N)(=O)=O)cc2)nc2c(=O)n(C)c(=O)nc1-2 | Homo sapiens | CHEMBL4610601 | single protein format |
| CHEMBL4216399 |  |
IC50 | = | 48.0 | nM | 390.51 | O=C(O)c1ccncc1NC[C@@H]1CCCc2cc(Sc3ccccc3)ccc21 | Homo sapiens | CHEMBL4193838 | single protein format |
| CHEMBL3785832 |  |
IC50 | = | 54.0 | nM | 329.74 | O=C(O)c1ccnc(-n2nccc2OCc2ccc(Cl)cc2)c1 | Homo sapiens | CHEMBL4223292 | single protein format |
| CHEMBL3775262 |  |
IC50 | = | 64.0 | nM | 350.33 | O=C(O)c1ccnc(-c2cc(NC(=O)c3ccc(O)cc3)ccc2O)c1 | Homo sapiens | CHEMBL3776325 | assay format |
| CHEMBL3775867 |  |
IC50 | = | 65.0 | nM | 339.31 | Cc1cc(C(=O)Nc2ccc(O)c(-c3cc(C(=O)O)ccn3)c2)no1 | Homo sapiens | CHEMBL3776325 | assay format |