Q9H3N8 | HRH4_HUMAN | Histamine H4 receptor (HRH4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 32~358 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1091874 |  |
IC50 | = | 1.0 | nM | 317.78 | CN[C@@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1 | Homo sapiens | CHEMBL1103488 | single protein format |
| CHEMBL1091875 |  |
IC50 | = | 13.0 | nM | 317.78 | CN[C@H]1CCN(c2nc(N)nc3c2oc2ccc(Cl)cc23)C1 | Homo sapiens | CHEMBL1103488 | single protein format |
| CHEMBL1093180 |  |
IC50 | = | 19.0 | nM | 302.76 | CN1CCN(c2ncnc3c2oc2ccc(Cl)cc23)CC1 | Homo sapiens | CHEMBL1103488 | single protein format |
| CHEMBL4778864 |  |
IC50 | = | 22.0 | nM | 302.77 | CN1CCN(c2nc3ccc(Cl)cc3n3cnnc23)CC1 | Homo sapiens | CHEMBL4767101 | cell membrane format |
| CHEMBL4790724 |  |
IC50 | = | 27.0 | nM | 335.17 | CNC1CN(c2nc3ncc(Br)cc3n3nnnc23)C1 | Homo sapiens | CHEMBL4767101 | cell membrane format |
| CHEMBL4783487 |  |
IC50 | = | 28.0 | nM | 349.2 | CN1CCN(c2nc3ncc(Br)cc3n3nnnc23)CC1 | Homo sapiens | CHEMBL4767101 | cell membrane format |
| CHEMBL1088859 |  |
IC50 | = | 30.0 | nM | 336.32 | CN[C@@H]1CCN(c2ncnc3c2oc2ccc(C(F)(F)F)cc23)C1 | Homo sapiens | CHEMBL1103488 | single protein format |
| CHEMBL1090190 |  |
IC50 | = | 33.0 | nM | 302.77 | CN[C@@H]1CCN(c2ncnc3c2oc2ccc(Cl)cc23)C1 | Homo sapiens | CHEMBL1103488 | single protein format |
| CHEMBL4778591 |  |
IC50 | = | 34.0 | nM | 395.21 | CN1CCN(c2nc3ncc(I)cc3n3cnnc23)CC1 | Homo sapiens | CHEMBL4767101 | cell membrane format |
| CHEMBL1091558 |  |
IC50 | = | 37.0 | nM | 316.79 | Cc1nc(N2CCN(C)CC2)c2oc3ccc(Cl)cc3c2n1 | Homo sapiens | CHEMBL1103488 | single protein format |
| CHEMBL4793974 |  |
IC50 | = | 52.0 | nM | 329.8 | Clc1cnc2nc(N3CCN4CCCC4C3)c3nncn3c2c1 | Homo sapiens | CHEMBL4767101 | cell membrane format |
| CHEMBL4781484 |  |
IC50 | = | 53.0 | nM | 290.72 | CNC1CN(c2nc3ncc(Cl)cc3n3nnnc23)C1 | Homo sapiens | CHEMBL4767101 | cell membrane format |
| CHEMBL4787983 |  |
IC50 | = | 62.0 | nM | 304.75 | CN1CCN(c2nc3ncc(Cl)cc3n3nnnc23)CC1 | Homo sapiens | CHEMBL4767101 | cell membrane format |
| CHEMBL4782303 |  |
IC50 | = | 65.0 | nM | 289.73 | CNC1CN(c2nc3ncc(Cl)cc3n3cnnc23)C1 | Homo sapiens | CHEMBL4767101 | cell membrane format |
| CHEMBL4778068 |  |
IC50 | = | 67.0 | nM | 348.21 | CN1CCN(c2nc3ncc(Br)cc3n3cnnc23)CC1 | Homo sapiens | CHEMBL4767101 | cell membrane format |
| CHEMBL4797517 |  |
IC50 | = | 77.0 | nM | 303.76 | CN1CCN(c2nc3ncc(Cl)cc3n3cnnc23)CC1 | Homo sapiens | CHEMBL4767101 | cell membrane format |
| CHEMBL1092542 |  |
IC50 | = | 83.0 | nM | 370.76 | CN1CCN(c2nc(C(F)(F)F)nc3c2oc2ccc(Cl)cc23)CC1 | Homo sapiens | CHEMBL1103488 | single protein format |
| CHEMBL129198 |  |
IC50 | = | 86.0 | nM | 277.76 | CN1CCN(C(=O)c2cc3cc(Cl)ccc3[nH]2)CC1 | Homo sapiens | CHEMBL2050323 | single protein format |
| CHEMBL1091729 |  |
IC50 | = | 86.0 | nM | 282.35 | CN[C@@H]1CCN(c2ncnc3c2oc2ccc(C)cc23)C1 | Homo sapiens | CHEMBL1103488 | single protein format |
| CHEMBL1091569 |  |
IC50 | = | 87.0 | nM | 288.74 | CNC1CN(c2ncnc3c2oc2ccc(Cl)cc23)C1 | Homo sapiens | CHEMBL1103488 | single protein format |