Q9H2X6 | HIPK2_HUMAN | Homeodomain-interacting protein kinase 2 (HIPK2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 199~527 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4228654 |  |
IC50 | < | 3.0 | nM | 373.42 | CC(C)Nc1ccc2cnn(-c3cncc(-c4ccc(C(=O)O)cc4)n3)c2c1 | Homo sapiens | CHEMBL4222678 | single protein format |
| CHEMBL2062577 |  |
IC50 | < | 3.0 | nM | 385.43 | CC(=O)N(C)c1ccc2ccn(-c3cc(NC4CC4)n4ncc(C#N)c4n3)c2c1 | Homo sapiens | CHEMBL2065460 | single protein format |
| CHEMBL2062581 |  |
IC50 | < | 3.0 | nM | 371.4 | CC(=O)Nc1ccc2[nH]cc(-c3cc(NC4CC4)n4ncc(C#N)c4n3)c2c1 | Homo sapiens | CHEMBL2065460 | single protein format |
| CHEMBL4750420 |  |
IC50 | = | 5.0 | nM | 311.34 | c1ccc2cc(-c3coc4ccc(-c5cn[nH]c5)nc34)ccc2c1 | Homo sapiens | CHEMBL4739023 | single protein format |
| CHEMBL4743939 |  |
IC50 | = | 15.0 | nM | 291.31 | COc1ccc(-c2coc3ccc(-c4cn[nH]c4)nc23)cc1 | Homo sapiens | CHEMBL4739023 | single protein format |
| CHEMBL2062565 |  |
IC50 | = | 20.0 | nM | 372.39 | CC(=O)Nc1cnc2ccn(-c3cc(NC4CC4)n4ncc(C#N)c4n3)c2c1 | Homo sapiens | CHEMBL2065460 | single protein format |
| CHEMBL4790791 |  |
IC50 | = | 28.0 | nM | 265.28 | Cn1cc(-c2coc3ccc(-c4cn[nH]c4)nc23)cn1 | Homo sapiens | CHEMBL4739023 | single protein format |
| CHEMBL4754195 |  |
IC50 | = | 29.0 | nM | 352.4 | Cn1cc(-c2ccc3occ(-c4cccc(-c5ccncc5)c4)c3n2)cn1 | Homo sapiens | CHEMBL4728310 | single protein format |
| CHEMBL4762964 |  |
IC50 | = | 30.0 | nM | 341.37 | Cn1cc(-c2ccc3occ(-c4cccc(-c5cc[nH]n5)c4)c3n2)cn1 | Homo sapiens | CHEMBL4739023 | single protein format |
| CHEMBL2062563 |  |
IC50 | = | 30.0 | nM | 371.4 | CC(=O)Nc1ccc2ccn(-c3cc(NC4CC4)n4ncc(C#N)c4n3)c2c1 | Homo sapiens | CHEMBL2065460 | single protein format |
| CHEMBL3937369 |  |
IC50 | = | 30.0 | nM | 416.49 | c1cnc2ncn(-c3cc(Nc4ccc(OCCN5CCCCC5)cn4)ncn3)c2c1 | Homo sapiens | CHEMBL4329879 | single protein format |
| CHEMBL2409175 |  |
IC50 | = | 40.0 | nM | 361.41 | CC(=O)Nc1cc(Nc2cc(NC3CC3)n3ncc(C#N)c3n2)ccc1C | Homo sapiens | CHEMBL2410931 | single protein format |
| CHEMBL3103192 |  |
IC50 | = | 40.0 | nM | 419.49 | CC(=O)Nc1cc(Nc2cc(NC3CC3)n3ncc(C#N)c3n2)ccc1N(C)CCN | Homo sapiens | CHEMBL3810701 | single protein format |
| CHEMBL4743730 |  |
IC50 | = | 41.0 | nM | 301.35 | C=C(C)c1ccc(-c2coc3ccc(-c4cn[nH]c4)nc23)cc1 | Homo sapiens | CHEMBL4739023 | single protein format |
| CHEMBL4790030 |  |
IC50 | = | 42.0 | nM | 261.28 | c1ccc(-c2coc3ccc(-c4cn[nH]c4)nc23)cc1 | Homo sapiens | CHEMBL4739023 | single protein format |
| CHEMBL2062564 |  |
IC50 | = | 50.0 | nM | 372.39 | CC(=O)Nc1ccc2cnn(-c3cc(NC4CC4)n4ncc(C#N)c4n3)c2c1 | Homo sapiens | CHEMBL2065460 | single protein format |
| CHEMBL2062575 |  |
IC50 | = | 60.0 | nM | 416.49 | CC(=O)Nc1ccc2ccn(-c3cc(NCCCN(C)C)n4ncc(C#N)c4n3)c2c1 | Homo sapiens | CHEMBL2065460 | single protein format |
| CHEMBL4740998 |  |
IC50 | = | 68.0 | nM | 315.38 | CC1(c2ccc(-c3coc4ccc(-c5cn[nH]c5)nc34)cc2)CC1 | Homo sapiens | CHEMBL4739023 | single protein format |
| CHEMBL4797457 |  |
IC50 | = | 70.0 | nM | 355.4 | Cn1cc(-c2cccc(-c3coc4ccc(-c5cnn(C)c5)nc34)c2)cn1 | Homo sapiens | CHEMBL4739023 | single protein format |
| CHEMBL4587433 |  |
IC50 | = | 74.0 | nM | 383.43 | O=C1NC(=O)/C(=C\c2c[nH]c(=O)c(-c3ccc(N4CCNCC4)nc3)c2)S1 | Homo sapiens | CHEMBL4739038 | single protein format |