Q9H2S1 | KCNN2_HUMAN | Small conductance calcium-activated potassium channel protein 2 (KCNN2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF02888 | CaMBD - Calmodulin binding domain | 412~486 | |
| PF03530 | SK_channel - Calcium-activated SK potassium channel | 121~235 | |
| PF07885 | Ion_trans_2 - Ion channel | 319~397 |
3D structures mapped by conservation among orthologs
[ Domain: "Small-conductance potassium channel" // CaMBD ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL476339 |  |
IC50 | = | 59.0 | nM | 268.35 | Cc1ccnc(Nc2nc(-c3ccccn3)cs2)c1 | Homo sapiens | CHEMBL991555 | cell-based format |
| CHEMBL472452 |  |
IC50 | = | 530.0 | nM | 264.74 | Clc1cc(NCc2cccs2)n2nccc2n1 | Homo sapiens | CHEMBL995896 | cell-based format |
| CHEMBL489770 |  |
IC50 | = | 543.0 | nM | 254.32 | c1ccc(Nc2nc(-c3ccccn3)cs2)nc1 | Homo sapiens | CHEMBL991555 | cell-based format |
| CHEMBL1182632 |  |
Ki | = | 277.0 | nM | 454.61 | COc1cc2c(cc1OC)[C@H](CCC[C@H]1c3cc(OC)c(OC)cc3CCN1C)N(C)CC2 | Homo sapiens | CHEMBL5360137 | cell-based format |