Q9H2K2 | TNKS2_HUMAN | Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)

Pfam Domain Table

AccessionDomainRangeColor
PF00023Ank - Ankyrin repeat124~154
PF00023Ank - Ankyrin repeat212~242
PF00023Ank - Ankyrin repeat746~775
PF00644PARP - Poly(ADP-ribose) polymerase catalytic domain963~1128
PF07647SAM_2 - SAM domain (Sterile alpha motif)877~933
PF12796Ank_2 - Ankyrin repeats (3 copies)28~121
PF12796Ank_2 - Ankyrin repeats (3 copies)246~305
PF12796Ank_2 - Ankyrin repeats (3 copies)381~461
PF12796Ank_2 - Ankyrin repeats (3 copies)556~622
PF12796Ank_2 - Ankyrin repeats (3 copies)649~742
PF13606Ank_3 - Ankyrin repeat528~553

3D structures mapped by conservation among orthologs

[ Domain: "SAM domain-like" // SAM_1 ]

 PyMOL session

[ Domain: "Ankyrin repeat" // Ank_2 ]

 PyMOL session

[ Domain: "ADP-ribosylation" // PARP ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL4069447 IC50 = 0.1 nM 477.52 Cc1cccc2c(=O)[nH]c(CCC(=O)Nc3ccc(C(=O)Nc4cccc5cccnc45)cc3)nc12 Homo sapiens CHEMBL4003541 single protein format
CHEMBL3805393 IC50 = 0.16 nM 440.48 COc1ccc(C(=O)C2CCN(C(=O)CCCc3cn4cc(F)cc4c(=O)[nH]3)CC2)cn1 Homo sapiens CHEMBL3807234 single protein format
CHEMBL3806163 IC50 = 0.17 nM 439.49 COc1ccc(C(=O)C2CCN(C(=O)CCCc3cn4cc(F)cc4c(=O)[nH]3)CC2)cc1 Homo sapiens CHEMBL3807234 single protein format
CHEMBL3805896 IC50 = 0.18 nM 435.52 COc1ccc(C(=O)C2CCN(C(=O)CCCc3cn4c(C)ccc4c(=O)[nH]3)CC2)cc1 Homo sapiens CHEMBL3807234 single protein format
CHEMBL3804939 IC50 = 0.19 nM 467.59 COc1ccc(C(=O)C2CCN(C(=O)CCCc3nc4c(C)scc4c(=O)[nH]3)CC2)cc1C Homo sapiens CHEMBL3807234 single protein format
CHEMBL4634919 IC50 = 0.19 nM 434.5 CCN(C(=O)N1CCC(C(=O)c2ccc3cnn(C)c3c2)CC1)c1ccc(C(=O)O)cc1 Homo sapiens CHEMBL4627148 single protein format
CHEMBL4098188 IC50 = 0.2 nM 463.5 O=C(CCc1nc2ccccc2c(=O)[nH]1)Nc1ccc(C(=O)Nc2cccc3cccnc23)cc1 Homo sapiens CHEMBL4003522 cell-based format
CHEMBL4632401 IC50 = 0.25 nM 464.52 CCN(C(=O)N1CCC(C(=O)c2ccc3c(C(=O)O)nn(C)c3c2)CC1)c1ccc(OC)cc1 Homo sapiens CHEMBL4627148 single protein format
CHEMBL4640008 IC50 = 0.26 nM 463.53 CCN(C(=O)N1CCC(C(=O)c2ccc3cc(C(=O)O)n(C)c3c2)CC1)c1ccc(OC)cc1 Homo sapiens CHEMBL4627148 single protein format
CHEMBL4643690 IC50 = 0.27 nM 434.5 CCN(C(=O)N1CCC(C(=O)c2ccc3ncn(C)c3c2)CC1)c1ccc(C(=O)O)cc1 Homo sapiens CHEMBL4627148 single protein format
CHEMBL3806049 IC50 = 0.28 nM 438.53 CC(C)n1cc(C(=O)C2CCN(C(=O)CCCc3nc4c(ccn4C)c(=O)[nH]3)CC2)cn1 Homo sapiens CHEMBL3807234 single protein format
CHEMBL4639702 IC50 = 0.29 nM 434.5 CCN(C(=O)N1CCC(C(=O)c2ccc3c(cnn3C)c2)CC1)c1ccc(C(=O)O)cc1 Homo sapiens CHEMBL4627148 single protein format
CHEMBL4638701 IC50 = 0.3 nM 494.65 O=c1[nH]c(SCCN2CCN(CCSc3nc4ccccc4c(=O)[nH]3)CC2)nc2ccccc12 Homo sapiens CHEMBL4616008 single protein format
CHEMBL3110106 IC50 = 0.4 nM 482.99 N#Cc1ccc(O[C@H]2CC[C@H](NC(=O)CCSc3nc4ccccc4c(=O)[nH]3)CC2)cc1Cl Homo sapiens CHEMBL3111838 single protein format
CHEMBL4645574 IC50 = 0.44 nM 463.53 CCN(C(=O)N1CCC(C(=O)c2ccc3c(c2)cc(C(=O)O)n3C)CC1)c1ccc(OC)cc1 Homo sapiens CHEMBL4627148 single protein format
CHEMBL4458129 IC50 = 0.5 nM 312.34 Cc1cc(F)cc2c(=O)[nH]c(-c3ccc(C(C)(C)O)cc3)nc12 Homo sapiens CHEMBL4322250 cell-based format
CHEMBL4101890 IC50 = 0.6 nM 428.54 Cc1cc(N2C[C@@H](C)N[C@@H](C)C2)ncc1-c1ccc(-c2nc3c(ccn3C)c(=O)[nH]2)cc1 Homo sapiens CHEMBL3995366 assay format
CHEMBL4567515 IC50 = 0.7 nM 373.86 Cc1cc(F)cc2c(=O)[nH]c(-c3ccc(C4CCNCC4)cc3)nc12.Cl Homo sapiens CHEMBL4322250 cell-based format
CHEMBL5070513 IC50 = 0.73 nM 511.61 CCOc1ccc(-c2nnc([C@H]3C[C@H](NC(=O)c4ccnc5cccnc45)C3)n2-c2ccc(C)s2)nc1 Homo sapiens CHEMBL5030370 single protein format
CHEMBL5274873 IC50 = 0.9 nM 283.33 Cc1ccc2c(=O)[nH]c(-c3ccc(C(C)(C)O)cc3)nn12 Homo sapiens CHEMBL5228278 single protein format