Q9H2G2 | SLK_HUMAN | STE20-like serine/threonine-protein kinase (SLK)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 35~292 | |
| PF12474 | PKK - Polo kinase kinase | 852~990 | |
| PF12474 | PKK - Polo kinase kinase | 1020~1160 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3326006 |  |
IC50 | = | 6.14 | nM | 476.67 | CCCCNc1ncc2c(-c3ccc(CN4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 | Homo sapiens | CHEMBL3363361 | single protein format |
| CHEMBL156277 |  |
IC50 | = | 7.8 | nM | 328.76 | COc1ccccc1C1=C(Nc2cccc(Cl)c2)C(=O)NC1=O | Homo sapiens | CHEMBL4839429 | single protein format |
| CHEMBL4875188 |  |
IC50 | = | 8.2 | nM | 319.32 | COc1ccccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O | Homo sapiens | CHEMBL4839429 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 14.6 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328606 | single protein format |
| CHEMBL4283353 |  |
IC50 | = | 47.0 | nM | 504.72 | CCC[C@H](C)Nc1ncc2c(-c3ccc(CN4CCCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 | Homo sapiens | CHEMBL4276360 | assay format |
| CHEMBL402548 |  |
IC50 | = | 621.0 | nM | 474.57 | CO[C@@H](C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1)c1ccccc1 | Homo sapiens | CHEMBL911847 | single protein format |
| CHEMBL5404639 |  |
IC50 | = | 892.0 | nM | 497.58 | C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccc(F)cc23)c1 | Homo sapiens | CHEMBL5384916 | assay format |
| CHEMBL103667 |  |
IC50 | < | 1000.0 | nM | 527.67 | Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 | Homo sapiens | CHEMBL4602932 | single protein format |
| CHEMBL4875188 | |
Ki | = | 3.7 | nM | 319.32 | COc1ccccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O | Homo sapiens | CHEMBL4839426 | single protein format |
| CHEMBL4878325 |  |
Ki | = | 3.9 | nM | 398.22 | COc1cc(Br)ccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O | Homo sapiens | CHEMBL4839426 | single protein format |
| CHEMBL4877889 |  |
Ki | = | 6.0 | nM | 344.37 | COc1ccccc1C1=C(Nc2cccc3ccccc23)C(=O)NC1=O | Homo sapiens | CHEMBL4839426 | single protein format |
| CHEMBL156277 | |
Ki | = | 6.6 | nM | 328.76 | COc1ccccc1C1=C(Nc2cccc(Cl)c2)C(=O)NC1=O | Homo sapiens | CHEMBL4839426 | single protein format |
| CHEMBL157089 |  |
Ki | = | 8.5 | nM | 344.75 | COc1ccccc1C1=C(Nc2ccc(O)c(Cl)c2)C(=O)NC1=O | Homo sapiens | CHEMBL4839426 | single protein format |
| CHEMBL4856751 |  |
Ki | = | 9.7 | nM | 398.22 | COc1ccc(Br)cc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O | Homo sapiens | CHEMBL4839426 | single protein format |
| CHEMBL4855513 |  |
Ki | = | 13.0 | nM | 312.3 | COc1ccccc1C1=C(Nc2cccc(F)c2)C(=O)NC1=O | Homo sapiens | CHEMBL4839426 | single protein format |
| CHEMBL4869745 |  |
Ki | = | 15.0 | nM | 338.32 | COc1ccccc1C1=C(Nc2ccc3c(c2)OCO3)C(=O)NC1=O | Homo sapiens | CHEMBL4839426 | single protein format |
| CHEMBL4857159 |  |
Ki | = | 17.0 | nM | 340.4 | COc1ccccc1C1=C(Nc2cccc(SC)c2)C(=O)NC1=O | Homo sapiens | CHEMBL4839426 | single protein format |
| CHEMBL157141 |  |
Ki | = | 17.0 | nM | 349.17 | O=C1NC(=O)C(c2ccccc2Cl)=C1Nc1ccc(O)c(Cl)c1 | Homo sapiens | CHEMBL4839426 | single protein format |
| CHEMBL4867952 |  |
Ki | = | 17.0 | nM | 404.43 | COc1cc(NC(=O)C(C)C)ccc1C1=C(Nc2cccc(C#N)c2)C(=O)NC1=O | Homo sapiens | CHEMBL4839426 | single protein format |
| CHEMBL4868821 |  |
Ki | = | 17.0 | nM | 345.36 | COc1ccccc1C1=C(Nc2ccc3ncccc3c2)C(=O)NC1=O | Homo sapiens | CHEMBL4839426 | single protein format |