Q9H237 | PORCN_HUMAN | Protein-serine O-palmitoleoyltransferase porcupine (PORCN)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF03062 | MBOAT - MBOAT, membrane-bound O-acyltransferase family | 63~363 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2139947 |  |
IC50 | = | 0.074 | nM | 379.46 | Cc1cc(-c2ccc(CC(=O)Nc3ccc(-c4cccnc4)cc3)cc2)ccn1 | Homo sapiens | CHEMBL3635400 | cell-based format |
| CHEMBL3623895 |  |
IC50 | = | 0.11 | nM | 411.47 | Cc1cc(-c2ccc(OC(C)C(=O)Nc3ccc(-c4cnccn4)cn3)cc2)ccn1 | Homo sapiens | CHEMBL3626166 | cell-based format |
| CHEMBL3623894 |  |
IC50 | = | 0.19 | nM | 395.47 | Cc1cc(-c2ccc(CCC(=O)Nc3ccc(-c4cnccn4)cn3)cc2)ccn1 | Homo sapiens | CHEMBL3626166 | cell-based format |
| CHEMBL3623875 |  |
IC50 | = | 0.23 | nM | 383.41 | Cc1cc(-c2ccc(OC(=O)Nc3ccc(-c4cnccn4)cn3)cc2)ccn1 | Homo sapiens | CHEMBL3626166 | cell-based format |
| CHEMBL3188386 |  |
IC50 | = | 0.4 | nM | 396.45 | Cc1cc(-c2ncc(CC(=O)Nc3ccc(-c4cnccn4)cn3)cc2C)ccn1 | Homo sapiens | CHEMBL3635400 | cell-based format |
| CHEMBL4080208 |  |
IC50 | = | 0.4 | nM | 395.44 | Cn1c(=O)c2c(ncn2CC(=O)Nc2ccc(-c3ccsc3)cc2)n(C)c1=O | Homo sapiens | CHEMBL4040031 | cell-based format |
| CHEMBL3633801 |  |
IC50 | = | 0.5 | nM | 409.47 | C[C@@H](C(=O)Nc1ccc(-c2ccsc2)cc1)n1cnc2c1c(=O)n(C)c(=O)n2C | Homo sapiens | CHEMBL3635401 | cell-based format |
| CHEMBL3623893 |  |
IC50 | = | 0.53 | nM | 413.51 | Cc1cc(-c2ccc(SCC(=O)Nc3ccc(-c4cnccn4)cn3)cc2)ccn1 | Homo sapiens | CHEMBL3626166 | cell-based format |
| CHEMBL3623896 |  |
IC50 | = | 0.57 | nM | 396.45 | Cc1ccc(-c2ncc(CC(=O)Nc3ccc(-c4cnccn4)cn3)cc2C)cn1 | Homo sapiens | CHEMBL3626166 | cell-based format |
| CHEMBL3623892 |  |
IC50 | = | 0.67 | nM | 410.48 | Cc1cc(-c2ccc(N(C)CC(=O)Nc3ccc(-c4cnccn4)cn3)cc2)ccn1 | Homo sapiens | CHEMBL3626166 | cell-based format |
| CHEMBL3623891 |  |
IC50 | = | 0.96 | nM | 396.45 | Cc1cc(-c2ccc(NCC(=O)Nc3ccc(-c4cnccn4)cn3)cc2)ccn1 | Homo sapiens | CHEMBL3626166 | cell-based format |
| CHEMBL4088716 |  |
IC50 | = | 1.0 | nM | 399.46 | C[C@H](Nc1ccc(-c2ccnn2C)nc1)C(=O)Nc1ccc(-c2cccnc2)cn1 | Homo sapiens | CHEMBL4000296 | cell-based format |
| CHEMBL4096728 |  |
IC50 | = | 1.0 | nM | 376.42 | CN1C(=O)C2=C(C1=O)N(CC(=O)Nc1ccc(-c3ccccc3)cn1)CCC2 | Homo sapiens | CHEMBL4040031 | cell-based format |
| CHEMBL4080021 |  |
IC50 | = | 1.0 | nM | 377.4 | CN1C(=O)C2=C(C1=O)N(CC(=O)Nc1ccc(-c3ccccc3)nn1)CCC2 | Homo sapiens | CHEMBL4040031 | cell-based format |
| CHEMBL4080842 |  |
IC50 | = | 1.0 | nM | 398.47 | C[C@H](Nc1ccc(-c2ccnn2C)nc1)C(=O)Nc1ccc(-c2ccccc2)cn1 | Homo sapiens | CHEMBL4000296 | cell-based format |
| CHEMBL4070649 |  |
IC50 | = | 2.0 | nM | 383.45 | Cc1nccn1-c1ccc(OCC(=O)Nc2ccc(-c3ccccc3)cc2)cc1 | Homo sapiens | CHEMBL4000296 | cell-based format |
| CHEMBL3623874 |  |
IC50 | = | 2.2 | nM | 381.44 | Cc1cc(-c2ccc(OC(=O)Nc3ccc(-c4cccnc4)cc3)cc2)ccn1 | Homo sapiens | CHEMBL3626166 | cell-based format |
| CHEMBL3623887 |  |
IC50 | = | 2.7 | nM | 381.4 | N#Cc1ccc2cc(OCC(=O)Nc3ccc(-c4cnccn4)cn3)ccc2c1 | Homo sapiens | CHEMBL3626166 | cell-based format |
| CHEMBL3633802 |  |
IC50 | = | 2.9 | nM | 391.39 | Cn1c(=O)c2c(ncn2CC(=O)Nc2ccc(-c3ccccc3)nn2)n(C)c1=O | Homo sapiens | CHEMBL3635401 | cell-based format |
| CHEMBL4099279 |  |
IC50 | = | 4.0 | nM | 383.45 | Cn1nccc1-c1ccc(OCC(=O)Nc2ccc(-c3ccccc3)cc2)cc1 | Homo sapiens | CHEMBL4000296 | cell-based format |