Q9H228 | S1PR5_HUMAN | Sphingosine 1-phosphate receptor 5 (S1PR5)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 53~306 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL381872 |  |
IC50 | = | 0.3 | nM | 431.41 | O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(CCC(F)(F)F)cc4)n3)cc2)C1 | Homo sapiens | CHEMBL880433 | cell-based format |
| CHEMBL195014 |  |
IC50 | = | 0.4 | nM | 439.46 | O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)C1 | Homo sapiens | CHEMBL880433 | cell-based format |
| CHEMBL198976 |  |
IC50 | = | 0.5 | nM | 403.48 | O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(C5CCCC5)cc4)n3)cc2)C1 | Homo sapiens | CHEMBL880433 | cell-based format |
| CHEMBL198415 |  |
IC50 | = | 0.5 | nM | 439.46 | O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc([C@H]5CCC(F)(F)C5)cc4)n3)cc2)C1 | Homo sapiens | CHEMBL880433 | cell-based format |
| CHEMBL225155 |  |
IC50 | = | 0.55 | nM | 379.48 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)COP(=O)(O)O | Homo sapiens | CHEMBL913923 | cell-based format |
| CHEMBL184879 |  |
IC50 | = | 0.73 | nM | 381.5 | CCCCCCCCCc1ccc(C2CCC(CCP(=O)(O)O)N2)cc1 | Homo sapiens | CHEMBL833013 | cell-based format |
| CHEMBL1161691 |  |
IC50 | = | 0.77 | nM | 389.47 | CCCCCCCCc1ccc(CCC(N)(CO)CO[PH](O)(O)O)cc1 | Homo sapiens | CHEMBL833013 | cell-based format |
| CHEMBL114606 |  |
IC50 | = | 0.77 | nM | 387.46 | CCCCCCCCc1ccc(CCC(N)(CO)COP(=O)(O)O)cc1 | Homo sapiens | CHEMBL913923 | cell-based format |
| CHEMBL196534 |  |
IC50 | = | 0.8 | nM | 417.51 | O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(C5CCCCC5)cc4)n3)cc2)C1 | Homo sapiens | CHEMBL880433 | cell-based format |
| CHEMBL194419 |  |
IC50 | = | 1.0 | nM | 391.47 | CC(C)Cc1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 | Homo sapiens | CHEMBL880433 | cell-based format |
| CHEMBL193789 |  |
IC50 | = | 1.0 | nM | 391.47 | CCCCc1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 | Homo sapiens | CHEMBL880433 | cell-based format |
| CHEMBL1973936 |  |
IC50 | = | 1.0 | nM | 363.38 | O=C(O)C1CN(Cc2ccc(CCc3cccc(C(F)(F)F)c3)cc2)C1 | Homo sapiens | CHEMBL3744618 | cell-based format |
| CHEMBL1966501 |  |
IC50 | = | 1.0 | nM | 379.38 | Cc1cc(OCc2cccc(C(F)(F)F)c2)ccc1CN1CC(C(=O)O)C1 | Homo sapiens | CHEMBL3744618 | cell-based format |
| CHEMBL3739440 |  |
IC50 | = | 1.0 | nM | 333.47 | CCCCCCCCCOc1ccc(CN2CC(C(=O)O)C2)cc1 | Homo sapiens | CHEMBL3744618 | cell-based format |
| CHEMBL1990223 |  |
IC50 | = | 1.0 | nM | 380.27 | Cc1cc(OCc2ccc(Cl)c(Cl)c2)ccc1CN1CC(C(=O)O)C1 | Homo sapiens | CHEMBL3744618 | cell-based format |
| CHEMBL3741414 |  |
IC50 | < | 1.0 | nM | 399.47 | CCCCCCCCOc1ccc([C@@H]2CC[C@](N)(COP(=O)(O)O)C2)cc1 | Homo sapiens | CHEMBL3744618 | cell-based format |
| CHEMBL3741092 |  |
IC50 | = | 1.0 | nM | 399.8 | O=C(O)C1CN(Cc2ccc(OCc3cccc(C(F)(F)F)c3)c(Cl)c2)C1 | Homo sapiens | CHEMBL3744618 | cell-based format |
| CHEMBL473269 |  |
IC50 | = | 1.1 | nM | 443.46 | CCCCCCCCOc1ccc(-c2c[nH]c([C@@](C)(N)COP(=O)(O)O)n2)cc1F | Homo sapiens | CHEMBL1029038 | single protein format |
| CHEMBL181597 |  |
IC50 | = | 1.2 | nM | 395.52 | CCCCCCCCCc1ccc(CN[C@H]2CCC[C@H](P(=O)(O)O)C2)cc1 | Homo sapiens | CHEMBL833013 | cell-based format |
| CHEMBL474689 |  |
IC50 | = | 1.4 | nM | 425.47 | CCCCCCCCOc1ccc(-c2c[nH]c([C@@](C)(N)COP(=O)(O)O)n2)cc1 | Homo sapiens | CHEMBL1029038 | single protein format |