Q9H1R3 | MYLK2_HUMAN | Myosin light chain kinase 2, skeletal/cardiac muscle (MYLK2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 287~540 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL388978 |  |
IC50 | = | 13.9 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328501 | single protein format |
| CHEMBL3774448 |  |
IC50 | = | 157.0 | nM | 272.35 | O=C1NC(=S)S/C1=C\c1ccc2ncccc2c1 | Homo sapiens | CHEMBL3776317 | assay format |
| CHEMBL4092824 |  |
IC50 | = | 350.0 | nM | 349.43 | Cc1cc(-c2cc(C(F)F)c(OC[C@@](C)(N)CC(C)C)cn2)ccn1 | Homo sapiens | CHEMBL5161246 | single protein format |
| CHEMBL5199698 |  |
IC50 | = | 450.0 | nM | 385.4 | CC(C)C[C@](C)(N)COc1cnc(-c2ccnc(C(F)F)c2)cc1C(F)F | Homo sapiens | CHEMBL5161246 | single protein format |
| CHEMBL5091582 |  |
IC50 | = | 479.0 | nM | 366.35 | Cc1nn(CC(F)(F)F)cc1Nc1nccc(NCCc2cnc[nH]2)n1 | Homo sapiens | CHEMBL5046611 | single protein format |
| CHEMBL5195653 |  |
IC50 | = | 600.0 | nM | 372.47 | COC(=O)Nc1cc(-c2cc(C)c(OC[C@@](C)(N)CC(C)C)cn2)ccn1 | Homo sapiens | CHEMBL5161246 | single protein format |
| CHEMBL5205578 |  |
IC50 | = | 650.0 | nM | 392.89 | COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(Cl)n2)ccn1 | Homo sapiens | CHEMBL5161246 | single protein format |
| CHEMBL2171124 |  |
IC50 | = | 701.0 | nM | 451.45 | Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(C(F)(F)F)c2)c2c(N)ncnc21 | Homo sapiens | CHEMBL2172943 | single protein format |