Q9H1D0 | TRPV6_HUMAN | Transient receptor potential cation channel subfamily V member 6 (TRPV6)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00023 | Ank - Ankyrin repeat | 203~233 | |
| PF00520 | Ion_trans - Ion transport protein | 394~627 | |
| PF12796 | Ank_2 - Ankyrin repeats (3 copies) | 89~185 |
3D structures mapped by conservation among orthologs
[ Domain: "Ankyrin repeat" // Ank_2 ]
[ Domain: "Voltage-gated ion channels" // Ion_trans ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4796516 |  |
IC50 | = | 64.0 | nM | 419.49 | O=c1ccc(CN2CCN([C@H]3CC[C@@H](c4cccc(C(F)(F)F)c4)CC3)CC2)c[nH]1 | Homo sapiens | CHEMBL4680527 | cell-based format |
| CHEMBL4777551 |  |
IC50 | = | 82.0 | nM | 435.49 | O=c1ccc(CN2CCN([C@H]3CC[C@@](O)(c4cccc(C(F)(F)F)c4)CC3)CC2)c[nH]1 | Homo sapiens | CHEMBL4680527 | cell-based format |
| CHEMBL4789936 |  |
IC50 | = | 130.0 | nM | 435.49 | O=c1ccc(CN2CCN([C@H]3CC[C@@](O)(c4ccccc4C(F)(F)F)CC3)CC2)c[nH]1 | Homo sapiens | CHEMBL4680527 | cell-based format |
| CHEMBL4740003 |  |
IC50 | = | 150.0 | nM | 365.52 | Cc1cccc([C@H]2CC[C@@H](N3CCN(Cc4ccc(=O)[nH]c4)CC3)CC2)c1 | Homo sapiens | CHEMBL4680527 | cell-based format |
| CHEMBL4760109 |  |
IC50 | = | 170.0 | nM | 414.39 | Brc1ccc(CN2CCN([C@H]3CC[C@@H](c4ccccc4)CC3)CC2)cn1 | Homo sapiens | CHEMBL4680527 | cell-based format |
| CHEMBL4435596 |  |
IC50 | = | 320.0 | nM | 335.5 | Cc1cccc([C@H]2CC[C@@H](N3CCN(c4cccnc4)CC3)CC2)c1 | Homo sapiens | CHEMBL4308175 | cell-based format |
| CHEMBL4762249 |  |
IC50 | = | 370.0 | nM | 351.49 | O=c1ccc(CN2CCN([C@H]3CC[C@@H](c4ccccc4)CC3)CC2)c[nH]1 | Homo sapiens | CHEMBL4680527 | cell-based format |
| CHEMBL4761058 |  |
IC50 | = | 430.0 | nM | 394.52 | COc1cc(C(=O)N2CCN([C@H]3CC[C@@H](c4ccccc4)CC3)CC2)ccc1O | Homo sapiens | CHEMBL4680527 | cell-based format |
| CHEMBL4475503 |  |
IC50 | = | 550.0 | nM | 335.5 | c1ccc([C@H]2CC[C@@H](N3CCN(Cc4cccnc4)CC3)CC2)cc1 | Homo sapiens | CHEMBL4680527 | cell-based format |
| CHEMBL4746237 |  |
IC50 | = | 550.0 | nM | 365.52 | COc1ccc(CN2CCN([C@H]3CC[C@@H](c4ccccc4)CC3)CC2)cn1 | Homo sapiens | CHEMBL4680527 | cell-based format |
| CHEMBL4470714 |  |
IC50 | = | 600.0 | nM | 439.61 | c1ccc(/N=N\c2ccc(CN3CCN([C@H]4CC[C@@H](c5ccccc5)CC4)CC3)cn2)cc1 | Homo sapiens | CHEMBL4308169 | cell-based format |
| CHEMBL4448267 |  |
IC50 | = | 600.0 | nM | 439.61 | c1ccc(/N=N/c2ccc(CN3CCN([C@H]4CC[C@@H](c5ccccc5)CC4)CC3)cn2)cc1 | Homo sapiens | CHEMBL4308166 | cell-based format |
| CHEMBL4789446 |  |
IC50 | = | 600.0 | nM | 365.48 | O=C(c1ccc(=O)[nH]c1)N1CCN([C@H]2CC[C@@H](c3ccccc3)CC2)CC1 | Homo sapiens | CHEMBL4680527 | cell-based format |
| CHEMBL4742895 |  |
IC50 | = | 690.0 | nM | 419.49 | O=c1ccc(CN2CCN([C@H]3CC[C@@H](c4ccccc4C(F)(F)F)CC3)CC2)c[nH]1 | Homo sapiens | CHEMBL4680527 | cell-based format |