Q9H0K1 | SIK2_HUMAN | Serine/threonine-protein kinase SIK2 (SIK2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 20~271 | |
| PF23312 | UBA_SIK3 - Protein kinase SIK3 UBA domain | 298~336 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL388978 |  |
IC50 | = | 0.37 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328604 | single protein format |
| CHEMBL5407103 |  |
IC50 | = | 0.4 | nM | 430.47 | CCc1nnc(-c2c(OC)cc(-c3cnc4cc(-c5cnn(C)c5)ccn34)cc2OC)o1 | Homo sapiens | CHEMBL5338273 | single protein format |
| CHEMBL5394880 |  |
IC50 | = | 0.6 | nM | 547.61 | COc1cc(-c2cnc(Nc3cc(N4CCN(C)CC4)nc(C)n3)s2)cc2c1C(=O)N(CC(F)(F)F)CC2 | Homo sapiens | CHEMBL5328196 | single protein format |
| CHEMBL5430450 |  |
IC50 | = | 0.61 | nM | 504.62 | COc1cc(-c2cnc(Nc3cc(N4CCN(C)CC4)nc(C)n3)s2)cc2c1C(=O)N(CC#N)CC2 | Homo sapiens | CHEMBL5328196 | single protein format |
| CHEMBL5426204 |  |
IC50 | = | 0.64 | nM | 577.63 | COc1cc(-c2cnc(Nc3cc(N4CCN(CCO)CC4)nc(C)n3)s2)cc2c1C(=O)N(CC(F)(F)F)CC2 | Homo sapiens | CHEMBL5328196 | single protein format |
| CHEMBL5417444 |  |
IC50 | = | 0.7 | nM | 453.45 | COc1cc(-n2cnc3cc(-c4cnn(C)c4)ccc32)cc(OC(F)F)c1C(=O)NC1CC1 | Homo sapiens | CHEMBL5338276 | single protein format |
| CHEMBL5438171 |  |
IC50 | = | 0.9 | nM | 391.43 | CCn1cc(-c2ccc3c(c2)ncn3-c2cc(OC)c(C(N)=O)c(OC)c2)cn1 | Homo sapiens | CHEMBL5345752 | single protein format |
| CHEMBL4539742 |  |
IC50 | = | 1.0 | nM | 336.42 | COc1ccc(-c2c[nH]c3nccc(-c4ccsc4)c23)c(OC)c1 | Homo sapiens | CHEMBL5151351 | single protein format |
| CHEMBL5398906 |  |
IC50 | < | 1.0 | nM | 409.44 | COc1c(F)cc(F)cc1-c1c[nH]c2ncc(-c3cnn(C4CCNCC4)c3)cc12 | Homo sapiens | CHEMBL5338273 | single protein format |
| CHEMBL5440720 |  |
IC50 | = | 1.6 | nM | 501.53 | COc1cc(-c2cnc3cc(OCCC4CCOCC4)ccn23)cc(OC(F)F)c1C(=O)NC1CC1 | Homo sapiens | CHEMBL5338276 | single protein format |
| CHEMBL5421558 |  |
IC50 | = | 1.9 | nM | 534.56 | COc1cc(-c2cnc(Nc3cc(N4CCOCC4)nc(C)n3)s2)cc2c1C(=O)N(CC(F)(F)F)CC2 | Homo sapiens | CHEMBL5328196 | single protein format |
| CHEMBL4859969 |  |
IC50 | = | 2.0 | nM | 514.46 | Cc1nc(Nc2ncc(C(=O)Nc3c(Cl)csc3Cl)s2)cc(N2CCN(CCO)CC2)n1 | Homo sapiens | CHEMBL4807588 | single protein format |
| CHEMBL5405960 |  |
IC50 | = | 2.3 | nM | 388.43 | CN1CC(Oc2cnc(C#N)cc2-c2ccn3nc(NC(=O)C4CC4)cc3c2)C1 | Homo sapiens | CHEMBL5328196 | single protein format |
| CHEMBL5431938 |  |
IC50 | = | 2.3 | nM | 455.47 | CCNC(=O)c1c(OC)cc(-n2cnc3cc(-c4cnn(CC)c4)ccc32)cc1OC(F)F | Homo sapiens | CHEMBL5345752 | single protein format |
| CHEMBL5427025 |  |
IC50 | = | 2.4 | nM | 378.43 | CCn1cc(-c2ccc3c(c2)ncn3-c2cc(OC)c(CO)c(OC)c2)cn1 | Homo sapiens | CHEMBL5345752 | single protein format |
| CHEMBL5412961 |  |
IC50 | = | 2.5 | nM | 431.5 | CCn1cc(-c2ccc3c(c2)ncn3-c2cc(OC)c(C(=O)NC3CC3)c(OC)c2)cn1 | Homo sapiens | CHEMBL5345752 | single protein format |
| CHEMBL5405883 |  |
IC50 | = | 2.6 | nM | 499.56 | COc1cc(-c2cnc3cc(N4CCC(N(C)C)CC4)ccn23)cc(OC(F)F)c1C(=O)NC1CC1 | Homo sapiens | CHEMBL5338276 | single protein format |
| CHEMBL5416410 |  |
IC50 | = | 3.0 | nM | 506.03 | Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1.O | Homo sapiens | CHEMBL4807588 | single protein format |
| CHEMBL288441 |  |
IC50 | < | 3.0 | nM | 530.46 | COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl | Homo sapiens | CHEMBL5371426 | single protein format |
| CHEMBL5404502 |  |
IC50 | = | 3.3 | nM | 473.46 | CCn1cc(-c2ccc3c(c2)ncn3-c2cc(OC)c(C(=O)NCC(F)(F)F)c(OC)c2)cn1 | Homo sapiens | CHEMBL5338276 | single protein format |