Q9H0J9 | PAR12_HUMAN | Protein mono-ADP-ribosyltransferase PARP12 (PARP12)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00644 | PARP - Poly(ADP-ribose) polymerase catalytic domain | 507~678 | |
| PF02825 | WWE - WWE domain | 377~458 | |
| PF23466 | WWE_4 - WWE domain | 299~360 | |
| PF24356 | WH_PARP12 - PARP12 winged helix domain | 4~68 | |
| PF25261 | zf-CCCH_PARP12 - PARP12-like CCCH zinc finger tandem | 73~123 | |
| PF25261 | zf-CCCH_PARP12 - PARP12-like CCCH zinc finger tandem | 173~206 |
3D structures mapped by conservation among orthologs
[ Domain: "ADP-ribosylation" // PARP ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5402698 |  |
IC50 | = | 14.1 | nM | 549.36 | O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCn2c(nnc2-c2ccc(Br)o2)C1 | Homo sapiens | CHEMBL5366437 | single protein format |
| CHEMBL5095043 |  |
IC50 | = | 26.0 | nM | 523.44 | C[C@@H](COCCC(=O)N1CCN(c2ncc(C(F)(F)F)cn2)CC1)Nc1cn[nH]c(=O)c1C(F)(F)F | Homo sapiens | CHEMBL5317580 | cell-based format |
| CHEMBL1094636 |  |
IC50 | = | 79.0 | nM | 320.4 | NC(=O)c1cccc2cn(-c3ccc([C@@H]4CCCNC4)cc3)nc12 | Homo sapiens | CHEMBL3995369 | assay format |
| CHEMBL5404785 |  |
IC50 | = | 160.0 | nM | 250.28 | COc1ccc(OC)c2c1sc1nnc(N)n12 | Homo sapiens | CHEMBL5318204 | assay format |
| CHEMBL372303 |  |
IC50 | = | 230.0 | nM | 295.34 | CN(C)CC(=O)Nc1ccc2[nH]c(=O)c3ccccc3c2c1 | Homo sapiens | CHEMBL3995369 | assay format |
| CHEMBL5395820 |  |
IC50 | = | 453.0 | nM | 534.47 | C[C@@H](CN1CC(C(=O)N2CCN(c3ncc(C(F)(F)F)cn3)CC2)C1)Nc1cn[nH]c(=O)c1C(F)(F)F | Homo sapiens | CHEMBL5317580 | cell-based format |
| CHEMBL521686 |  |
IC50 | = | 690.0 | nM | 434.47 | O=C(c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F)N1CCN(C(=O)C2CC2)CC1 | Homo sapiens | CHEMBL5373906 | cell-based format |