Q9GZQ6 | NPFF1_HUMAN | Neuropeptide FF receptor 1 (NPFFR1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 60~329 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2208337 |  |
Ki | = | 0.32 | nM | 500.6 | N=C(N)NCCC[C@H](NC(=O)c1ccccc1-c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL2215251 | cell-based format |
| CHEMBL2208303 |  |
Ki | = | 0.8 | nM | 450.54 | N=C(N)NCCC[C@@H](NC(=O)/C=C/c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL2215251 | cell-based format |
| CHEMBL2208301 |  |
Ki | = | 0.9 | nM | 573.72 | N=C(N)NCCC[C@H](NC(=O)CCN1c2ccccc2Sc2ccccc21)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL2215251 | cell-based format |
| CHEMBL4793841 |  |
Ki | = | 1.0 | nM | 242.11 | NC1=NC=C(c2ccc(Cl)c(Cl)c2)CN1 | Homo sapiens | CHEMBL4772288 | cell membrane format |
| CHEMBL2208325 |  |
Ki | = | 2.0 | nM | 500.6 | N=C(N)NCCC[C@@H](NC(=O)c1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL2215251 | cell-based format |
| CHEMBL2208338 |  |
Ki | = | 2.0 | nM | 500.6 | N=C(N)NCCC[C@@H](NC(=O)c1ccccc1-c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL2215251 | cell-based format |
| CHEMBL5090293 |  |
Ki | = | 4.3 | nM | 526.64 | N=C(N)NCCC[C@@H](NC(=O)C=C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL5042863 | cell-based format |
| CHEMBL5085324 |  |
Ki | = | 4.7 | nM | 492.62 | CC(C)C[C@H](NC(=O)[C@@H](CCCNC(=N)N)NC(=O)C=C(c1ccccc1)c1ccccc1)C(N)=O | Homo sapiens | CHEMBL5042863 | cell-based format |
| CHEMBL2208320 |  |
Ki | = | 5.0 | nM | 500.6 | N=C(N)NCCC[C@@H](NC(=O)c1ccccc1-c1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL2215251 | cell-based format |
| CHEMBL2208322 |  |
Ki | = | 6.0 | nM | 500.6 | N=C(N)NCCC[C@@H](NC(=O)c1cccc(-c2ccccc2)c1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL2215251 | cell-based format |
| CHEMBL5071745 |  |
Ki | = | 6.3 | nM | 565.68 | N=C(N)NCCC[C@@H](NC(=O)C=C(c1ccccc1)c1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O | Homo sapiens | CHEMBL5042863 | cell-based format |
| CHEMBL5075638 |  |
Ki | = | 6.6 | nM | 540.67 | N=C(N)NCCC[C@@H](NC(=O)C=C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](CCc1ccccc1)C(N)=O | Homo sapiens | CHEMBL5042863 | cell-based format |
| CHEMBL5074999 |  |
Ki | = | 7.2 | nM | 526.64 | N=C(N)NCCC[C@@H](NC(=O)C=C(c1ccccc1)c1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL5042863 | cell-based format |
| CHEMBL2208319 |  |
Ki | = | 10.0 | nM | 514.63 | N=C(N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL2215251 | cell-based format |
| CHEMBL2208340 |  |
Ki | = | 11.0 | nM | 424.51 | N=C(N)NCCC[C@@H](NC(=O)c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL2215251 | cell-based format |
| CHEMBL5091013 |  |
Ki | = | 11.2 | nM | 436.52 | N=C(N)NCCC[C@@H](NC(=O)C=C(c1ccccc1)c1ccccc1)C(=O)NCC(N)=O | Homo sapiens | CHEMBL5042863 | cell-based format |
| CHEMBL332347 |  |
Ki | = | 12.0 | nM | 473.58 | NC(N)=NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 | Homo sapiens | CHEMBL3750357 | cell-based format |
| CHEMBL2440929 |  |
Ki | = | 12.0 | nM | 473.58 | N=C(N)NCCC[C@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 | Homo sapiens | CHEMBL4772232 | cell-based format |
| CHEMBL4777535 |  |
Ki | = | 13.0 | nM | 200.25 | Cc1cc(NC(=N)N)nc2ccccc12 | Homo sapiens | CHEMBL4772260 | single protein format |
| CHEMBL2208299 |  |
Ki | = | 15.0 | nM | 514.63 | N=C(N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL2215251 | cell-based format |