Q9C0B1 | FTO_HUMAN | Alpha-ketoglutarate-dependent dioxygenase FTO (FTO)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF12933 | FTO_NTD - FTO catalytic domain | 37~325 | |
| PF12934 | FTO_CTD - FTO C-terminal domain | 329~497 |
3D structures mapped by conservation among orthologs
[ Domain: "Double-stranded beta-helix" // FTO_NTD ]
[ Domain: "Alpha-ketoglutarate-dependent dioxygenase FTO helical domain" // FTO_CTD ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4572939 |  |
IC50 | = | 60.0 | nM | 377.23 | Cc1noc(C)c1-c1cc(Cl)c(Nc2ccccc2C(=O)O)c(Cl)c1 | Homo sapiens | CHEMBL4418244 | single protein format |
| CHEMBL5195767 |  |
IC50 | = | 70.0 | nM | 312.41 | c1ccc(-c2ccc(CNCC3(N4CCCC4)COC3)o2)cc1 | Homo sapiens | CHEMBL5142379 | single protein format |
| CHEMBL5219846 |  |
IC50 | = | 80.0 | nM | 332.27 | O=C(O)CNC(=O)c1nc(Nc2ccc([N+](=O)[O-])cc2)ccc1O | Homo sapiens | CHEMBL5216103 | assay format |
| CHEMBL5196484 |  |
IC50 | = | 87.0 | nM | 545.34 | Cc1c(Nc2ccncc2C(=O)NNC(=O)/C=C/C(=O)O)cc(Cl)c(Nc2ccccc2[N+](=O)[O-])c1Cl | Homo sapiens | CHEMBL5132491 | single protein format |
| CHEMBL5200892 |  |
IC50 | = | 110.0 | nM | 303.38 | Fc1ccc2[nH]cc(CNCC3(N4CCCC4)COC3)c2c1 | Homo sapiens | CHEMBL5142379 | single protein format |
| CHEMBL5410889 |  |
IC50 | = | 120.0 | nM | 496.01 | Cc1noc(C)c1-c1cc(Cl)c(Nc2cccc(CN3CCCOCC3)c2C(=O)O)c(C2CC2)c1 | Homo sapiens | CHEMBL5350726 | single protein format |
| CHEMBL5207866 |  |
IC50 | = | 160.0 | nM | 346.42 | FC(F)(F)Sc1ccc(CNCC2(N3CCCC3)COC2)cc1 | Homo sapiens | CHEMBL5142379 | single protein format |
| CHEMBL5174419 |  |
IC50 | = | 200.0 | nM | 362.22 | Cc1n[nH]cc1-c1cc(Cl)c(Nc2ccccc2C(=O)O)c(Cl)c1 | Homo sapiens | CHEMBL5125060 | assay format |
| CHEMBL4448030 |  |
IC50 | <= | 250.0 | nM | 284.23 | N#C/C(=C\c1cc(O)c(O)c([N+](=O)[O-])c1)c1cnccn1 | Homo sapiens | CHEMBL4418739 | single protein format |
| CHEMBL5194680 |  |
IC50 | = | 270.0 | nM | 328.48 | c1ccc(-c2ccc(CNCC3(N4CCCC4)COC3)s2)cc1 | Homo sapiens | CHEMBL5142379 | single protein format |
| CHEMBL4563060 |  |
IC50 | <= | 300.0 | nM | 328.24 | N#C/C(=C\c1cc(O)c(O)c([N+](=O)[O-])c1)c1cnc(C(=O)O)cn1 | Homo sapiens | CHEMBL4418739 | single protein format |
| CHEMBL5220094 |  |
IC50 | = | 330.0 | nM | 333.26 | O=C(O)CNC(=O)c1nc(Nc2ccc([N+](=O)[O-])cn2)ccc1O | Homo sapiens | CHEMBL5216103 | assay format |
| CHEMBL465179 |  |
IC50 | = | 340.0 | nM | 257.68 | CN(C)c1nc(N)c(C(=O)NC(=N)N)nc1Cl | Homo sapiens | CHEMBL5229154 | single protein format |
| CHEMBL5204291 |  |
IC50 | = | 350.0 | nM | 299.42 | Cc1ccc2[nH]cc(CNCC3(N4CCCC4)COC3)c2c1 | Homo sapiens | CHEMBL5142379 | single protein format |
| CHEMBL5207797 |  |
IC50 | = | 350.0 | nM | 274.41 | Cc1ccc(CNCC2(N3CCCC3)COC2)cc1C | Homo sapiens | CHEMBL5142379 | single protein format |
| CHEMBL4532629 |  |
IC50 | = | 400.0 | nM | 401.26 | Cc1noc(C)c1-c1cc(Cl)c(Nc2ccccc2-c2nn[nH]n2)c(Cl)c1 | Homo sapiens | CHEMBL4418244 | single protein format |
| CHEMBL5219336 |  |
IC50 | = | 430.0 | nM | 344.33 | CNC(=O)c1ccc(Nc2ccc(O)c(C(=O)NCC(=O)O)n2)cc1 | Homo sapiens | CHEMBL5216103 | assay format |
| CHEMBL5203668 |  |
IC50 | = | 440.0 | nM | 321.37 | Fc1ccc2c(CNCC3(N4CCC(F)C4)COC3)c[nH]c2c1 | Homo sapiens | CHEMBL5142379 | single protein format |
| CHEMBL5275957 |  |
IC50 | = | 490.0 | nM | 555.66 | COc1cccc2c1C1CN(CCCCn3c(=O)[nH]c4c(sc5ncc(-c6ccccc6)nc54)c3=O)CC1CO2 | Homo sapiens | CHEMBL5229154 | single protein format |
| CHEMBL4467308 |  |
IC50 | <= | 500.0 | nM | 300.23 | N#C/C(=C(/O)c1cc(O)c(O)c([N+](=O)[O-])c1)c1ccncn1 | Homo sapiens | CHEMBL4418739 | single protein format |