Q9BZP6 | CHIA_HUMAN | Acidic mammalian chitinase (CHIA)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00704 | Glyco_hydro_18 - Glycosyl hydrolases family 18 | 24~365 | |
| PF01607 | CBM_14 - Chitin binding Peritrophin-A domain | 430~476 |
3D structures mapped by conservation among orthologs
[ Domain: "Chitinase insertion domain" // GH18_chitolectin_chitotriosidase ]
[ Domain: "TIM barrels" // Glyco_hydro_18 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4643001 |  |
IC50 | = | 0.7 | nM | 486.45 | CN1C[C@H](Cc2ccc(Cl)cc2)N(C2CCN(c3n[nH]c(N)n3)CC2)Cc2cc(Cl)ccc21 | Homo sapiens | CHEMBL4619014 | cell-based format |
| CHEMBL4635305 |  |
IC50 | = | 1.4 | nM | 452.01 | CN1C[C@H](Cc2ccc(Cl)cc2)N(C2CCN(c3n[nH]c(N)n3)CC2)Cc2ccccc21 | Homo sapiens | CHEMBL4619014 | cell-based format |
| CHEMBL4756869 |  |
IC50 | = | 1.6 | nM | 433.0 | CC(C)C[C@H]1CN(C2CCN(c3nc(N)n[nH]3)CC2)[C@@H](Cc2ccc(Cl)cc2)CO1 | Homo sapiens | CHEMBL4704017 | cell-based format |
| CHEMBL4634943 |  |
IC50 | = | 2.0 | nM | 426.95 | Nc1nc(N2CCC(N(CCc3ccc(Cl)cc3)Cc3cccc(O)c3)CC2)n[nH]1 | Homo sapiens | CHEMBL4619014 | cell-based format |
| CHEMBL4637417 |  |
IC50 | = | 2.0 | nM | 426.95 | Nc1nc(N2CCC(N(CCc3ccc(Cl)cc3)Cc3ccccc3O)CC2)n[nH]1 | Homo sapiens | CHEMBL4619014 | cell-based format |
| CHEMBL4794014 |  |
IC50 | = | 3.4 | nM | 418.97 | CC(C)[C@H]1CN(C2CCN(c3nc(N)n[nH]3)CC2)[C@@H](Cc2ccc(Cl)cc2)CO1 | Homo sapiens | CHEMBL4704017 | cell-based format |
| CHEMBL4084573 |  |
IC50 | = | 3.4 | nM | 461.01 | Nc1n[nH]c(N2CCC(N(CCc3ccc(Cl)cc3)Cc3cccc4ccccc34)CC2)n1 | Homo sapiens | CHEMBL4022939 | cell-based format |
| CHEMBL4077644 |  |
IC50 | = | 3.5 | nM | 445.4 | Nc1n[nH]c(N2CCC(N(CCc3ccc(Cl)cc3)Cc3ccccc3Cl)CC2)n1 | Homo sapiens | CHEMBL4022939 | cell-based format |
| CHEMBL4646309 |  |
IC50 | = | 4.0 | nM | 445.4 | Nc1nc(N2CCC(N(CCc3ccc(Cl)cc3)Cc3ccc(Cl)cc3)CC2)n[nH]1 | Homo sapiens | CHEMBL4619014 | cell-based format |
| CHEMBL4646247 |  |
IC50 | = | 5.0 | nM | 446.93 | Nc1nc(N2CCC(N(CCc3ccc(Cl)cc3)Cc3cc(F)ccc3F)CC2)n[nH]1 | Homo sapiens | CHEMBL4619014 | cell-based format |
| CHEMBL4632547 |  |
IC50 | = | 5.0 | nM | 463.39 | Nc1nc(N2CCC(N(CCc3ccc(Cl)cc3)Cc3ccc(F)cc3Cl)CC2)n[nH]1 | Homo sapiens | CHEMBL4619014 | cell-based format |
| CHEMBL4077482 |  |
IC50 | = | 5.4 | nM | 410.95 | Nc1n[nH]c(N2CCC(N(CCc3ccc(Cl)cc3)Cc3ccccc3)CC2)n1 | Homo sapiens | CHEMBL4022939 | cell-based format |
| CHEMBL4649081 |  |
IC50 | = | 6.0 | nM | 445.4 | Nc1nc(N2CCC(N(CCc3ccc(Cl)cc3)Cc3cccc(Cl)c3)CC2)n[nH]1 | Homo sapiens | CHEMBL4619014 | cell-based format |
| CHEMBL4789376 |  |
IC50 | = | 6.8 | nM | 406.92 | Nc1n[nH]c(N2CCC(N3C[C@H](CO)OC[C@@H]3Cc3ccc(Cl)cc3)CC2)n1 | Homo sapiens | CHEMBL4704017 | cell-based format |
| CHEMBL4640857 |  |
IC50 | = | 7.0 | nM | 438.96 | Nc1nc(N2CCC(N3Cc4ccccc4OC[C@@H]3Cc3ccc(Cl)cc3)CC2)n[nH]1 | Homo sapiens | CHEMBL4619014 | cell-based format |
| CHEMBL4648962 |  |
IC50 | = | 7.0 | nM | 456.95 | Nc1nc(N2CCC(N3Cc4cc(F)ccc4OC[C@@H]3Cc3ccc(Cl)cc3)CC2)n[nH]1 | Homo sapiens | CHEMBL4619014 | cell-based format |
| CHEMBL4764430 |  |
IC50 | = | 7.0 | nM | 434.97 | CC(C)(O)[C@H]1CN(C2CCN(c3nc(N)n[nH]3)CC2)[C@@H](Cc2ccc(Cl)cc2)CO1 | Homo sapiens | CHEMBL4704017 | cell-based format |
| CHEMBL4638897 |  |
IC50 | = | 8.0 | nM | 473.41 | Nc1nc(N2CCC(N3Cc4cc(Cl)ccc4OC[C@@H]3Cc3ccc(Cl)cc3)CC2)n[nH]1 | Homo sapiens | CHEMBL4619014 | cell-based format |
| CHEMBL4068944 |  |
IC50 | = | 8.7 | nM | 421.39 | CC(C)CN(CCc1ccc(Br)cc1)C1CCN(c2nc(N)n[nH]2)CC1 | Homo sapiens | CHEMBL4022939 | cell-based format |
| CHEMBL4082060 |  |
IC50 | = | 8.7 | nM | 417.0 | Nc1n[nH]c(N2CCC(N(CCc3ccc(Cl)cc3)CC3CCCCC3)CC2)n1 | Homo sapiens | CHEMBL4022939 | cell-based format |