Q9BZL6 | KPCD2_HUMAN | Serine/threonine-protein kinase D2 (PRKD2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 555~807 | |
| PF00130 | C1_1 - Phorbol esters/diacylglycerol binding domain (C1 domain) | 139~189 | |
| PF00130 | C1_1 - Phorbol esters/diacylglycerol binding domain (C1 domain) | 265~314 | |
| PF00169 | PH - PH domain | 400~473 | |
| PF25525 | Ubiquitin_PRKD1_N - Serine/threonine-protein kinase D1-like, ubiquitin-like domain | 45~127 |
3D structures mapped by conservation among orthologs
[ Domain: "PH domain-like" // PH ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1215000 |  |
IC50 | = | 1.0 | nM | 374.45 | NC(=O)c1cc(-c2ccnc(Nc3ccccc3)c2)nc(N2CCNCC2)c1 | Homo sapiens | CHEMBL1219873 | single protein format |
| CHEMBL1215151 |  |
IC50 | = | 1.0 | nM | 403.53 | c1cc(-c2cc(-c3cn[nH]c3)cc(N3CCNCC3)n2)cc(NC2CCCCC2)n1 | Homo sapiens | CHEMBL1219873 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 1.33 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328573 | single protein format |
| CHEMBL1214998 |  |
IC50 | = | 2.0 | nM | 388.52 | c1cc2c(N3CCNCC3)nc(-c3ccnc(NC4CCCCC4)c3)cc2cn1 | Homo sapiens | CHEMBL1219829 | single protein format |
| CHEMBL1215219 |  |
IC50 | = | 2.0 | nM | 405.51 | c1cc(-c2cc(-c3cn[nH]c3)cc(N3CCNCC3)n2)cc(NC2CCOCC2)n1 | Homo sapiens | CHEMBL1219873 | single protein format |
| CHEMBL1215153 |  |
IC50 | = | 2.0 | nM | 363.47 | CC(C)Nc1cc(-c2cc(-c3cn[nH]c3)cc(N3CCNCC3)n2)ccn1 | Homo sapiens | CHEMBL1219873 | single protein format |
| CHEMBL5419827 |  |
IC50 | = | 2.0 | nM | 454.57 | CCOc1ccc2cc(-c3cc(-c4cccc(C(=O)NCCN(C)C)c4)cnc3N)ccc2c1 | Homo sapiens | CHEMBL5316851 | single protein format |
| CHEMBL5428541 |  |
IC50 | = | 2.5 | nM | 338.42 | CC[C@H](N)CNc1ccnc(-c2cc(-c3cnn(C)c3)ccc2O)n1 | Homo sapiens | CHEMBL5316851 | single protein format |
| CHEMBL1215074 |  |
IC50 | = | 7.0 | nM | 378.44 | Cn1ccc(Nc2cc(-c3cc(C(N)=O)cc(N4CCNCC4)n3)ccn2)n1 | Homo sapiens | CHEMBL1219873 | single protein format |
| CHEMBL1215075 |  |
IC50 | = | 8.0 | nM | 408.89 | NC(=O)c1cc(-c2ccnc(Nc3ccccc3Cl)c2)nc(N2CCNCC2)c1 | Homo sapiens | CHEMBL1219873 | single protein format |
| CHEMBL1215002 |  |
IC50 | = | 8.0 | nM | 340.43 | CC(C)Nc1cc(-c2cc(C(N)=O)cc(N3CCNCC3)n2)ccn1 | Homo sapiens | CHEMBL1219873 | single protein format |
| CHEMBL1214999 |  |
IC50 | = | 9.0 | nM | 380.5 | NC(=O)c1cc(-c2ccnc(NC3CCCCC3)c2)nc(N2CCNCC2)c1 | Homo sapiens | CHEMBL1219873 | single protein format |
| CHEMBL5440043 |  |
IC50 | = | 9.0 | nM | 366.47 | NC(=O)c1cc(-c2ccnc(N3CCCCC3)c2)nc(N2CCNCC2)c1 | Homo sapiens | CHEMBL5316851 | single protein format |
| CHEMBL1215001 |  |
IC50 | = | 9.0 | nM | 382.47 | NC(=O)c1cc(-c2ccnc(NC3CCOCC3)c2)nc(N2CCNCC2)c1 | Homo sapiens | CHEMBL1219873 | single protein format |
| CHEMBL4515390 |  |
IC50 | = | 9.0 | nM | 338.42 | CC[C@@H](N)CNc1ccnc(-c2cc(-c3cnn(C)c3)ccc2O)n1 | Homo sapiens | CHEMBL4774310 | cell-based format |
| CHEMBL1214857 |  |
IC50 | = | 16.0 | nM | 474.61 | CC(C)NC(=O)C1CCN(c2nc(-c3ccnc(NC4CCOCC4)c3)cc3cnccc23)CC1 | Homo sapiens | CHEMBL1219829 | single protein format |
| CHEMBL4644939 |  |
IC50 | = | 17.0 | nM | 319.41 | Oc1ccc(-c2cc(NC3CCCNC3)c3ccncc3c2)cc1 | Homo sapiens | CHEMBL4619379 | single protein format |
| CHEMBL1215220 |  |
IC50 | = | 18.0 | nM | 380.5 | NC(=O)c1cc(N[C@@H]2CCNC2)nc(-c2ccnc(NC3CCCCC3)c2)c1 | Homo sapiens | CHEMBL1219873 | single protein format |
| CHEMBL1215077 |  |
IC50 | = | 31.0 | nM | 326.4 | CCNc1cc(-c2cc(C(N)=O)cc(N3CCNCC3)n2)ccn1 | Homo sapiens | CHEMBL1219873 | single protein format |
| CHEMBL4787572 |  |
IC50 | = | 35.0 | nM | 347.43 | Nc1ncnc2c1c(-c1c[nH]c3ccccc13)nn2CC1CCNCC1 | Homo sapiens | CHEMBL4774310 | cell-based format |