Q9BZ95 | NSD3_HUMAN | Histone-lysine N-methyltransferase NSD3 (NSD3)
Helixβ‑strandTurn secondary structure
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00855 | PWWP | 271–349 | |
| PF00855 | PWWP | 962–1048 | |
| PF00856 | SET | 1156–1262 | |
| PF17907 | AWS | 1104–1142 | |
| PF17982 | C5HCH | 1364–1413 | |
| PF22908 | PHD_NSD | 748–797 | |
| PF23004 | PHDvar_NSD | 799–851 | |
| PF23011 | PHD-1st_NSD | 697–746 |
3D structures mapped by conservation among orthologs
[ Domain: "SH3" // PWWP ]
[ Domain: "SET domain-like" // SET ]
[ Domain: "Zn3Cys9 preSET domain-related" // AWS ]
[ Domain: "FYVE/PHD zinc finger" // PHD_5 ]
[ Domain: "FYVE/PHD zinc finger" // zf-AN1_like ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5419719 |  |
IC50 | = | 1.0 | nM | 480.52 | COC[C@@]1(N)CCCN(c2cnc(-c3ccc(F)cc3F)cc2Cn2cnc3c(N)ncnc32)C1 | Homo sapiens | CHEMBL5364868 | cell-based format |
| CHEMBL5396709 |  |
IC50 | = | 1.0 | nM | 496.98 | COC[C@@]1(N)CCCN(c2cnc(-c3cc(Cl)ccc3F)cc2Cn2cnc3c(N)ncnc32)C1 | Homo sapiens | CHEMBL5364868 | cell-based format |
| CHEMBL5408212 |  |
IC50 | = | 1.0 | nM | 480.52 | COC[C@@]1(N)CCCN(c2cnc(-c3ccc(F)c(F)c3)cc2Cn2cnc3c(N)ncnc32)C1 | Homo sapiens | CHEMBL5364868 | cell-based format |
| CHEMBL5438312 |  |
IC50 | = | 1.0 | nM | 506.56 | Nc1ncnc2c1ncn2Cc1cc(-c2ccc(F)c(F)c2)ncc1N1CCC[C@](N)(COC2CC2)C1 | Homo sapiens | CHEMBL5364868 | cell-based format |
| CHEMBL5425629 |  |
IC50 | = | 1.0 | nM | 534.49 | Nc1ncnc2c1ncn2Cc1cc(-c2cc(F)c(F)cc2F)ncc1N1CCC[C@](N)([C@@H](O)C(F)F)C1 | Homo sapiens | CHEMBL5364868 | cell-based format |
| CHEMBL5433029 |  |
IC50 | = | 1.0 | nM | 546.53 | COc1cc(F)c(-c2cc(Cn3cnc4c(N)ncnc43)c(N3CCC[C@](N)([C@@H](O)C(F)F)C3)cn2)cc1F | Homo sapiens | CHEMBL5364868 | cell-based format |
| CHEMBL5432302 |  |
IC50 | = | 1.0 | nM | 532.62 | COc1ccc(-c2cc(Cn3cnc4c(N)ncnc43)c(N3CCC[C@](N)(COC4CCC4)C3)cn2)cc1F | Homo sapiens | CHEMBL5364868 | cell-based format |
| CHEMBL5186268 |  |
IC50 | = | 110.0 | nM | 449.6 | Cc1cc(CN2CCC(N)CC2)cc(C)c1-c1ncn(C)c1-c1ccc(C#N)c2ccccc12 | Homo sapiens | CHEMBL5364874 | assay format |
| CHEMBL4778517 |  |
IC50 | = | 200.0 | nM | 360.44 | Cc1cc(CN)cc(C)c1-c1ncn(C)c1-c1ccnc2cc(F)ccc12 | Homo sapiens | CHEMBL5124716 | single protein format |
| CHEMBL5277519 |  |
IC50 | = | 203.0 | nM | 356.47 | Cc1ccc2c(-c3c(-c4c(C)cc(CN)cc4C)ncn3C)ccnc2c1 | Homo sapiens | CHEMBL5232465 | single protein format |
| CHEMBL337173 |  |
IC50 | = | 340.0 | nM | 321.76 | O=C1C(Cl)=C(NCCN2CCOCC2)C(=O)c2ncccc21 | Homo sapiens | CHEMBL5318867 | single protein format |
| CHEMBL5422549 |  |
IC50 | = | 750.0 | nM | 355.78 | CC#CC(=O)NC12CC(NC3=C(Cl)C(=O)c4ncccc4C3=O)(C1)C2 | Homo sapiens | CHEMBL5318867 | single protein format |