Q9BYT3 | STK33_HUMAN | Serine/threonine-protein kinase 33 (STK33)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 116~381 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2203524 |  |
IC50 | = | 7.0 | nM | 444.54 | COc1ccc(-n2ncc3ccc(Nc4ccc(N5CCN(C)CC5)c(OC)c4)nc32)cc1 | Homo sapiens | CHEMBL2216290 | single protein format |
| CHEMBL2203525 |  |
IC50 | = | 11.0 | nM | 362.46 | CC(=O)NC[C@@H]1C[C@@H](NS(=O)(=O)c2cccc3cncc(C)c23)CN1 | Homo sapiens | CHEMBL2216290 | single protein format |
| CHEMBL2204239 |  |
IC50 | = | 14.0 | nM | 389.48 | CC(C)c1ccc(NC(=O)c2cccs2)c(-c2nc3ccccc3[nH]c2=O)c1 | Homo sapiens | CHEMBL2216290 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 36.3 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328619 | single protein format |
| CHEMBL2203528 |  |
IC50 | = | 76.0 | nM | 342.36 | O=C(Nc1ccccc1-c1nc2ccccc2[nH]c1=O)c1ccccn1 | Homo sapiens | CHEMBL2216290 | single protein format |
| CHEMBL2204241 |  |
IC50 | = | 78.0 | nM | 365.39 | O=C(Nc1cc(F)ccc1-c1nc2ccccc2[nH]c1=O)c1cccs1 | Homo sapiens | CHEMBL2216290 | single protein format |
| CHEMBL2204238 |  |
IC50 | = | 110.0 | nM | 431.39 | O=C(Nc1ccc(OC(F)(F)F)cc1-c1nc2ccccc2[nH]c1=O)c1cccs1 | Homo sapiens | CHEMBL2216290 | single protein format |
| CHEMBL2203530 |  |
IC50 | = | 150.0 | nM | 359.36 | O=C(Nc1ccccc1-c1nc2ccccc2[nH]c1=O)c1ccc(F)cc1 | Homo sapiens | CHEMBL2216290 | single protein format |
| CHEMBL2204235 |  |
IC50 | = | 160.0 | nM | 381.84 | O=C(Nc1ccc(Cl)cc1-c1nc2ccccc2[nH]c1=O)c1cccs1 | Homo sapiens | CHEMBL2216290 | single protein format |
| CHEMBL1992679 |  |
IC50 | = | 170.0 | nM | 341.37 | O=C(Nc1ccccc1-c1nc2ccccc2[nH]c1=O)c1ccccc1 | Homo sapiens | CHEMBL2216290 | single protein format |
| CHEMBL2204237 |  |
IC50 | = | 250.0 | nM | 377.43 | COc1ccc(NC(=O)c2cccs2)c(-c2nc3ccccc3[nH]c2=O)c1 | Homo sapiens | CHEMBL2216290 | single protein format |
| CHEMBL2204240 |  |
IC50 | = | 270.0 | nM | 381.84 | O=C(Nc1cc(Cl)ccc1-c1nc2ccccc2[nH]c1=O)c1cccs1 | Homo sapiens | CHEMBL2216290 | single protein format |
| CHEMBL1543343 |  |
IC50 | = | 280.0 | nM | 347.4 | O=C(Nc1ccccc1-c1nc2ccccc2nc1O)c1cccs1 | Homo sapiens | CHEMBL2216290 | single protein format |
| CHEMBL2203531 |  |
IC50 | = | 300.0 | nM | 375.82 | O=C(Nc1ccccc1-c1nc2ccccc2[nH]c1=O)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL2216290 | single protein format |
| CHEMBL2203526 |  |
IC50 | = | 380.0 | nM | 381.84 | O=C(Nc1ccccc1-c1nc2ccccc2[nH]c1=O)c1ccc(Cl)s1 | Homo sapiens | CHEMBL2216290 | single protein format |
| CHEMBL2204236 |  |
IC50 | = | 410.0 | nM | 365.39 | O=C(Nc1ccc(F)cc1-c1nc2ccccc2[nH]c1=O)c1cccs1 | Homo sapiens | CHEMBL2216290 | single protein format |
| CHEMBL2203527 |  |
IC50 | = | 530.0 | nM | 348.39 | O=C(Nc1ccccc1-c1nc2ccccc2[nH]c1=O)c1nccs1 | Homo sapiens | CHEMBL2216290 | single protein format |
| CHEMBL2203529 |  |
IC50 | = | 580.0 | nM | 342.36 | O=C(Nc1ccccc1-c1nc2ccccc2[nH]c1=O)c1cccnc1 | Homo sapiens | CHEMBL2216290 | single protein format |
| CHEMBL2203532 |  |
IC50 | = | 980.0 | nM | 371.4 | COc1ccc(C(=O)Nc2ccccc2-c2nc3ccccc3[nH]c2=O)cc1 | Homo sapiens | CHEMBL2216290 | single protein format |