Q9BYP7 | WNK3_HUMAN | Serine/threonine-protein kinase WNK3 (WNK3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 152~405 | |
| PF12202 | OSR1_C - Oxidative-stress-responsive kinase 1 C-terminal domain | 426~489 | |
| PF24889 | CCTL2_WNK - WNK CCTL2 domain | 745~816 |
3D structures mapped by conservation among orthologs
[ Domain: "WNK1 autoinhibitory domain" // OSR1_C_1 ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4281823 |  |
IC50 | = | 97.0 | nM | 481.48 | CCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 | Homo sapiens | CHEMBL4261434 | single protein format |
| CHEMBL2151321 |  |
IC50 | = | 99.8 | nM | 381.42 | CC(C)Oc1cc(-n2cnc3ccc(N[C@@H](C)c4ccc(F)cn4)nc32)n[nH]1 | Homo sapiens | CHEMBL2154718 | single protein format |
| CHEMBL2380845 |  |
IC50 | = | 401.0 | nM | 406.45 | O=C(Nc1ccc(Nc2ccnc3[nH]c(=O)c4ccccc4c23)cc1)c1ccccc1 | Homo sapiens | CHEMBL2382833 | single protein format |
| CHEMBL4793380 |  |
IC50 | = | 494.0 | nM | 423.48 | CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4c3OCCCN4)cc2)no1 | Homo sapiens | CHEMBL4767019 | single protein format |