Q9BYF1 | ACE2_HUMAN | Angiotensin-converting enzyme 2 (ACE2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01401 | Peptidase_M2 - Angiotensin-converting enzyme | 21~606 | |
| PF16959 | Collectrin - Renal amino acid transporter | 617~770 |
3D structures mapped by conservation among orthologs
[ Domain: "Metalloproteases ("zincins") catalytic domain" // Peptidase_M2 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL429844 |  |
IC50 | = | 0.44 | nM | 428.32 | CC(C)C[C@H](N[C@@H](Cc1cncn1Cc1cc(Cl)cc(Cl)c1)C(=O)O)C(=O)O | Homo sapiens | CHEMBL928323 | single protein format |
| CHEMBL5279656 |  |
IC50 | = | 0.44 | nM | 428.32 | CC(C)CC(NC(Cc1cncn1Cc1cc(Cl)cc(Cl)c1)C(=O)O)C(=O)O | Homo sapiens | CHEMBL5230436 | single protein format |
| CHEMBL5281591 |  |
IC50 | = | 1.0 | nM | 575.73 | CCC[C@@H]([C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)Nc1nccs1)N(O)C=O | Homo sapiens | CHEMBL5230436 | single protein format |
| CHEMBL5277567 |  |
IC50 | = | 100.0 | nM | 456.54 | CC(C)CC(CC(=O)NO)C(=O)NC(Cc1ccc2ccccc2c1)C(=O)NC(C)C(N)=O | Homo sapiens | CHEMBL5230436 | single protein format |
| CHEMBL5270233 |  |
IC50 | = | 200.0 | nM | 415.54 | CC(C)CC(CC(=O)NO)C(=O)NC(C(=O)NC(C)C(=O)NCCN)C(C)(C)C | Homo sapiens | CHEMBL5230436 | single protein format |
| CHEMBL5270175 |  |
IC50 | = | 700.0 | nM | 507.43 | O=C(NC(Cc1ccccc1)C(=O)N1CCC(O)(c2ccc(Br)cc2)CC1)c1ccccc1 | Homo sapiens | CHEMBL5230435 | cell-based format |
| CHEMBL1535 |  |
IC50 | = | 720.0 | nM | 335.88 | CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12 | Homo sapiens | CHEMBL5230436 | single protein format |
| CHEMBL260273 |  |
Ki | = | 0.13 | nM | 452.49 | CC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@@H]1P(=O)(O)C[C@@H](Cc1ccccc1)C(=O)O | Homo sapiens | CHEMBL929264 | single protein format |
| CHEMBL409105 |  |
Ki | = | 0.4 | nM | 543.52 | CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@@H]1P(=O)(O)CC(Cc1cc(-c2ccccc2)no1)C(=O)O | Homo sapiens | CHEMBL929264 | single protein format |
| CHEMBL261423 |  |
Ki | = | 0.7 | nM | 476.47 | CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@@H]1P(=O)(O)C[C@@H](Cc1ccccc1)C(=O)O | Homo sapiens | CHEMBL929264 | single protein format |
| CHEMBL261121 |  |
Ki | = | 1.25 | nM | 519.54 | CC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@@H]1P(=O)(O)CC(Cc1cc(-c2ccccc2)no1)C(=O)O | Homo sapiens | CHEMBL929264 | single protein format |
| CHEMBL258698 |  |
Ki | = | 5.2 | nM | 486.51 | CC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@@H]1P(=O)(O)C[C@@H](Cc1ccccc1)C(=O)O | Homo sapiens | CHEMBL929264 | single protein format |
| CHEMBL410509 |  |
Ki | = | 5.2 | nM | 502.5 | CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@@H]1P(=O)(O)C[C@@H](Cc1ccccc1)C(=O)O | Homo sapiens | CHEMBL929264 | single protein format |
| CHEMBL411942 |  |
Ki | = | 6.5 | nM | 467.5 | CC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1P(=O)(O)C[C@@H](Cc1ccccc1)C(=O)O | Homo sapiens | CHEMBL929264 | single protein format |
| CHEMBL411052 |  |
Ki | = | 6.6 | nM | 438.46 | CC(=O)N[C@H](C(=O)N1CCC[C@@H]1P(=O)(O)C[C@@H](Cc1ccccc1)C(=O)O)C(C)C | Homo sapiens | CHEMBL929264 | single protein format |
| CHEMBL263663 |  |
Ki | = | 7.0 | nM | 468.44 | CC(=O)N[C@@H](CCC(=O)O)C(=O)N1CCC[C@@H]1P(=O)(O)C[C@@H](Cc1ccccc1)C(=O)O | Homo sapiens | CHEMBL929264 | single protein format |
| CHEMBL409721 |  |
Ki | = | 7.5 | nM | 410.41 | CC(=O)N[C@@H](C)C(=O)N1CCC[C@@H]1P(=O)(O)C[C@@H](Cc1ccccc1)C(=O)O | Homo sapiens | CHEMBL929264 | single protein format |
| CHEMBL408182 |  |
Ki | = | 220.0 | nM | 559.56 | CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](CC(C)C)P(=O)(O)CC(Cc1cc(-c2ccccc2)no1)C(=O)O | Homo sapiens | CHEMBL929264 | single protein format |
| CHEMBL260677 |  |
Ki | = | 300.0 | nM | 431.43 | O=C(O)[C@H](Cc1ccccc1)CP(=O)(O)[C@H]1CCCN1C(=O)OCc1ccccc1 | Homo sapiens | CHEMBL929264 | single protein format |
| CHEMBL411298 |  |
Ki | = | 300.0 | nM | 397.41 | CC(C)C[C@H](CP(=O)(O)[C@H]1CCCN1C(=O)OCc1ccccc1)C(=O)O | Homo sapiens | CHEMBL929264 | single protein format |