Q9BY41 | HDAC8_HUMAN | Histone deacetylase 8 (HDAC8)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00850 | Hist_deacetyl - Histone deacetylase domain | 35~320 |
3D structures mapped by conservation among orthologs
[ Domain: "Arginase/deacetylase" // Hist_deacetyl ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4441774 |  |
IC50 | = | 0.41 | nM | 514.67 | CC(C)[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c2csc(n2)CNC(=O)C[C@@H](/C=C(\F)CCS)OC1=O | Homo sapiens | CHEMBL4363860 | cell-based format |
| CHEMBL4534486 |  |
IC50 | = | 0.8 | nM | 372.43 | O=C(NO)[C@H](Cc1ccccc1)n1nnc(-c2ccccc2)c1C#CC1CC1 | Homo sapiens | CHEMBL4431258 | single protein format |
| CHEMBL5274330 |  |
IC50 | = | 1.14 | nM | 554.51 | O=C(CCCCCC(=O)N(Cc1ccc(Br)s1)c1ccc(OCCN2CCOCC2)cc1)NO | Homo sapiens | CHEMBL5230969 | single protein format |
| CHEMBL4532398 |  |
IC50 | = | 1.28 | nM | 566.66 | C[C@@H]1CN(C(=O)Nc2ccc(-c3nc(N4CCOCC4)c4cnn(CCCCCCC(=O)NO)c4n3)cc2)CCO1 | Homo sapiens | CHEMBL4413542 | assay format |
| CHEMBL4067006 |  |
IC50 | = | 1.74 | nM | 406.44 | COc1cc(NC(=O)NOCCCCCC(=O)NO)c2nc(OC)cc(C)c2c1 | Homo sapiens | CHEMBL5241892 | single protein format |
| CHEMBL2235264 |  |
IC50 | = | 2.0 | nM | 418.33 | O=C(CCCCCCCC(=O)c1ccc(-c2ccc(Br)cc2)cc1)NO | Homo sapiens | CHEMBL3047468 | single protein format |
| CHEMBL4786031 |  |
IC50 | = | 2.4 | nM | 398.44 | O=C(CCCCCCC(=O)Nc1n[nH]c2cc(-c3ccccc3F)ccc12)NO | Homo sapiens | CHEMBL4768535 | cell-based format |
| CHEMBL4790137 |  |
IC50 | = | 3.0 | nM | 410.47 | COc1cccc(-c2ccc3c(NC(=O)CCCCCCC(=O)NO)n[nH]c3c2)c1 | Homo sapiens | CHEMBL4768535 | cell-based format |
| CHEMBL4529036 |  |
IC50 | = | 3.0 | nM | 432.48 | COc1cc(OC)cc(-c2nnn([C@@H](Cc3ccccc3)C(=O)NO)c2C#CC2CC2)c1 | Homo sapiens | CHEMBL4431258 | single protein format |
| CHEMBL4641682 |  |
IC50 | = | 3.0 | nM | 453.52 | CN1CC(C(=O)N[C@@H](CCCCCC(=O)c2ccon2)c2ncc(-c3ccccc3F)[nH]2)C1 | Homo sapiens | CHEMBL4625805 | assay format |
| CHEMBL4793650 |  |
IC50 | = | 3.2 | nM | 440.5 | COc1ccc(-c2ccc3c(NC(=O)CCCCCCC(=O)NO)n[nH]c3c2)cc1OC | Homo sapiens | CHEMBL4768535 | cell-based format |
| CHEMBL4786350 |  |
IC50 | = | 3.3 | nM | 414.89 | O=C(CCCCCCC(=O)Nc1n[nH]c2cc(-c3ccc(Cl)cc3)ccc12)NO | Homo sapiens | CHEMBL4768535 | cell-based format |
| CHEMBL4777182 |  |
IC50 | = | 3.3 | nM | 411.46 | COc1cccc(-c2ccc3c(NC(=O)CCCCCCC(=O)NO)n[nH]c3n2)c1 | Homo sapiens | CHEMBL4768535 | cell-based format |
| CHEMBL4776328 |  |
IC50 | = | 3.4 | nM | 424.5 | CCOc1cccc(-c2ccc3c(NC(=O)CCCCCCC(=O)NO)n[nH]c3c2)c1 | Homo sapiens | CHEMBL4768535 | cell-based format |
| CHEMBL4788954 |  |
IC50 | = | 3.6 | nM | 410.47 | COc1ccc(-c2ccc3c(NC(=O)CCCCCCC(=O)NO)n[nH]c3c2)cc1 | Homo sapiens | CHEMBL4768535 | cell-based format |
| CHEMBL4792980 |  |
IC50 | = | 3.8 | nM | 414.89 | O=C(CCCCCCC(=O)Nc1n[nH]c2cc(-c3cccc(Cl)c3)ccc12)NO | Homo sapiens | CHEMBL4768535 | cell-based format |
| CHEMBL2235262 |  |
IC50 | = | 4.0 | nM | 354.45 | O=C(CCCCCCC/C(=N\O)c1ccc(-c2ccccc2)cc1)NO | Homo sapiens | CHEMBL3047468 | single protein format |
| CHEMBL4792567 |  |
IC50 | = | 4.0 | nM | 414.89 | O=C(CCCCCCC(=O)Nc1n[nH]c2cc(-c3ccccc3Cl)ccc12)NO | Homo sapiens | CHEMBL4768535 | cell-based format |
| CHEMBL4476253 |  |
IC50 | = | 4.0 | nM | 378.46 | O=C(NO)[C@H](Cc1ccccc1)n1nnc(-c2ccsc2)c1C#CC1CC1 | Homo sapiens | CHEMBL4431258 | single protein format |
| CHEMBL4782066 |  |
IC50 | = | 4.1 | nM | 448.45 | O=C(CCCCCCC(=O)Nc1n[nH]c2cc(-c3cccc(C(F)(F)F)c3)ccc12)NO | Homo sapiens | CHEMBL4768535 | cell-based format |