Q9BV86 | NTM1A_HUMAN | N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF05891 | Methyltransf_PK - AdoMet dependent proline di-methyltransferase | 8~223 |
3D structures mapped by conservation among orthologs
[ Domain: "S-adenosyl-L-methionine-dependent methyltransferases" // Methyltransf_11_3 ]
[ Domain: "S-adenosyl-L-methionine-dependent methyltransferases" // Methyltransf_11_3,RNAse_Pc_like ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5403284 |  |
IC50 | = | 27.0 | nM | 405.5 | CC(C)(NC(=O)O[C@@H]1CN2CCC1CC2)c1csc(-c2ccc(F)c(O)c2)n1 | Homo sapiens | CHEMBL5318633 | cell-based format |
| CHEMBL4744916 |  |
IC50 | = | 100.0 | nM | 566.71 | N=C(N)NCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)Cc1cccc2ccccc12)C(N)=O | Homo sapiens | CHEMBL4689810 | assay format |
| CHEMBL5402262 |  |
IC50 | = | 110.0 | nM | 421.95 | CC(C)(NC(=O)O[C@@H]1CN2CCC1CC2)c1csc(-c2ccc(Cl)c(O)c2)n1 | Homo sapiens | CHEMBL5318633 | cell-based format |
| CHEMBL4761806 |  |
IC50 | = | 130.0 | nM | 529.64 | NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)Cc1cccc2ccccc12)C(=O)Nc1cccc(C(N)=O)c1 | Homo sapiens | CHEMBL4689810 | assay format |
| CHEMBL5427360 |  |
IC50 | = | 300.0 | nM | 405.5 | CC(C)(NC(=O)O[C@@H]1CN2CCC1CC2)c1csc(-c2ccc(F)cc2O)n1 | Homo sapiens | CHEMBL5318633 | cell-based format |
| CHEMBL4796649 |  |
IC50 | = | 340.0 | nM | 529.64 | NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)Cc1cccc2ccccc12)C(=O)Nc1ccccc1C(N)=O | Homo sapiens | CHEMBL4689810 | assay format |
| CHEMBL4740501 |  |
IC50 | = | 340.0 | nM | 481.6 | C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)Cc1cccc2ccccc12)C(N)=O | Homo sapiens | CHEMBL4689810 | assay format |
| CHEMBL161867 |  |
IC50 | = | 460.0 | nM | 267.36 | C/N=c1\nc(-c2ccccc2)n(-c2ccccc2)s1 | Homo sapiens | CHEMBL5119807 | assay format |
| CHEMBL4792508 |  |
IC50 | = | 470.0 | nM | 552.72 | CN(C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)Cc1cccc2ccccc12)[C@@H](CCCCN)C(N)=O | Homo sapiens | CHEMBL4689810 | assay format |
| CHEMBL4742945 |  |
IC50 | = | 490.0 | nM | 557.7 | NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL4689810 | assay format |
| CHEMBL4757419 |  |
IC50 | = | 500.0 | nM | 532.65 | N=C(N)NCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)Cc1ccc(O)cc1)C(N)=O | Homo sapiens | CHEMBL4689810 | assay format |
| CHEMBL4297611 |  |
IC50 | = | 500.0 | nM | 389.5 | CC(C)(NC(=O)O[C@@H]1CN2CCC1CC2)c1csc(-c2ccc(F)cc2)n1 | Homo sapiens | CHEMBL5119808 | assay format |
| CHEMBL5426033 |  |
IC50 | = | 560.0 | nM | 387.5 | CC(C)(NC(=O)O[C@@H]1CN2CCC1CC2)c1csc(-c2cccc(O)c2)n1 | Homo sapiens | CHEMBL5318633 | cell-based format |
| CHEMBL4764028 |  |
IC50 | = | 580.0 | nM | 495.62 | C[C@@H](C(N)=O)N(C)C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)Cc1cccc2ccccc12 | Homo sapiens | CHEMBL4689810 | assay format |
| CHEMBL4756093 |  |
IC50 | = | 600.0 | nM | 580.73 | CN(C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)Cc1cccc2ccccc12)[C@@H](CCCNC(=N)N)C(N)=O | Homo sapiens | CHEMBL4689810 | assay format |
| CHEMBL4781749 |  |
IC50 | = | 740.0 | nM | 540.67 | NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)Cc1cccc2ccccc12)C(=O)NCc1nc2ccccc2[nH]1 | Homo sapiens | CHEMBL4689810 | assay format |
| CHEMBL4751138 |  |
IC50 | = | 780.0 | nM | 538.69 | NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)Cc1cccc2ccccc12)C(N)=O | Homo sapiens | CHEMBL4689810 | assay format |
| CHEMBL4745007 |  |
IC50 | = | 840.0 | nM | 573.69 | NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O | Homo sapiens | CHEMBL4689810 | assay format |
| CHEMBL4796778 |  |
IC50 | = | 880.0 | nM | 584.7 | N=C(N)NCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)Cc1ccc(F)c2ccccc12)C(N)=O | Homo sapiens | CHEMBL4689810 | assay format |
| CHEMBL4797618 |  |
IC50 | = | 890.0 | nM | 567.7 | N=C(N)NCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)Cc1cccc2cccnc12)C(N)=O | Homo sapiens | CHEMBL4689810 | assay format |