Q9BV23 | ABHD6_HUMAN | Monoacylglycerol lipase ABHD6 (ABHD6)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00561 | Abhydrolase_1 - alpha/beta hydrolase fold | 72~313 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5274434 |  |
IC50 | = | 2.0 | nM | 517.51 | CC(C)(C)OC(=O)N1CCN(C(=O)n2cc(-c3ccc(OC(F)(F)F)cc3)nn2)C(c2ccccc2)C1 | Homo sapiens | CHEMBL5234403 | single protein format |
| CHEMBL3906477 |  |
IC50 | = | 2.5 | nM | 422.53 | O=C(N1CCCC[C@@H]1Cc1ccccc1)n1cc(-c2ccc(-c3ccccc3)cc2)nn1 | Homo sapiens | CHEMBL5234403 | single protein format |
| CHEMBL4279328 |  |
IC50 | = | 2.5 | nM | 420.52 | O=C(N1CCC=C[C@@H]1Cc1ccccc1)n1cc(-c2ccc(-c3ccccc3)cc2)nn1 | Homo sapiens | CHEMBL5234403 | single protein format |
| CHEMBL3895863 |  |
IC50 | = | 2.8 | nM | 542.59 | C#CCO[C@@H]1CC[C@H](Cc2ccccc2)N(C(=O)n2ncc(C(O)(c3ccc(F)cc3)c3ccc(F)cc3)n2)C1 | Homo sapiens | CHEMBL5234403 | single protein format |
| CHEMBL4581240 |  |
IC50 | = | 3.6 | nM | 531.54 | CC(C)(C)OC(=O)N1CCN(C(=O)n2cc(-c3ccc(OC(F)(F)F)cc3)nn2)C(Cc2ccccc2)C1 | Homo sapiens | CHEMBL5234403 | single protein format |
| CHEMBL113262 |  |
IC50 | = | 17.0 | nM | 370.49 | CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCP(=O)(F)OC | Homo sapiens | CHEMBL5234408 | single protein format |
| CHEMBL5284566 |  |
IC50 | = | 44.0 | nM | 340.45 | CN(C(=O)Oc1nsnc1N1CCOCC1)C1CCCCCC1 | Homo sapiens | CHEMBL5234401 | cell-based format |
| CHEMBL3613671 |  |
IC50 | = | 44.0 | nM | 354.48 | CN(C(=O)Oc1nsnc1N1CCOCC1)C1CCCCCCC1 | Homo sapiens | CHEMBL3614931 | cell-based format |
| CHEMBL175247 |  |
IC50 | = | 48.0 | nM | 495.75 | CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O | Homo sapiens | CHEMBL3405400 | cell-based format |
| CHEMBL4068554 |  |
IC50 | = | 70.0 | nM | 437.5 | CN(Cc1cccc(-c2ccncc2)c1)C(=O)Oc1ccc(-c2ccc(C(N)=O)cc2)cc1 | Homo sapiens | CHEMBL5234398 | cell-based format |
| CHEMBL3613162 |  |
IC50 | = | 73.0 | nM | 283.29 | Nc1cccc(Cn2nc(Oc3ccccc3)oc2=O)c1 | Homo sapiens | CHEMBL3614931 | cell-based format |
| CHEMBL4469632 |  |
IC50 | = | 91.0 | nM | 554.5 | Cn1ncc2cc(C(c3ccc4c(cnn4C)c3)N3CCN(C(=O)OC(C(F)(F)F)C(F)(F)F)CC3)ccc21 | Homo sapiens | CHEMBL4309850 | subcellular format |
| CHEMBL4436074 |  |
IC50 | = | 99.0 | nM | 517.49 | CS(=O)(=O)c1ccc(CN2CCN(C(=O)OC(C(F)(F)F)C(F)(F)F)CC2)c(N2CCCC2)c1 | Homo sapiens | CHEMBL4309850 | subcellular format |
| CHEMBL3613161 |  |
IC50 | = | 130.0 | nM | 313.27 | O=c1oc(Oc2ccccc2)nn1Cc1cccc([N+](=O)[O-])c1 | Homo sapiens | CHEMBL3614931 | cell-based format |
| CHEMBL3979183 |  |
IC50 | = | 130.0 | nM | 450.38 | Cn1cc(CN2CCN(C(=O)OC(C(F)(F)F)C(F)(F)F)CC2)c(-c2ccccc2)n1 | Homo sapiens | CHEMBL4309850 | subcellular format |
| CHEMBL3894067 |  |
IC50 | = | 170.0 | nM | 484.83 | Cn1cc(CN2CCN(C(=O)OC(C(F)(F)F)C(F)(F)F)CC2)c(-c2ccccc2Cl)n1 | Homo sapiens | CHEMBL4309850 | subcellular format |
| CHEMBL3910417 |  |
IC50 | = | 182.0 | nM | 448.37 | O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(C(c2cccnc2)c2cccnc2)CC1 | Homo sapiens | CHEMBL4309850 | subcellular format |
| CHEMBL4584757 |  |
IC50 | = | 190.0 | nM | 404.74 | O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(Cc2ccc(Cl)cc2)CC1 | Homo sapiens | CHEMBL4309850 | subcellular format |
| CHEMBL3613003 |  |
IC50 | = | 216.0 | nM | 221.22 | COc1nn(Cc2cccc(N)c2)c(=O)o1 | Homo sapiens | CHEMBL3614931 | cell-based format |
| CHEMBL3945728 |  |
IC50 | = | 253.0 | nM | 507.4 | O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(Cc2ccc(C(F)(F)F)cc2N2CCCC2)CC1 | Homo sapiens | CHEMBL4309908 | cell-based format |