Q9BSW2 | EFC4B_HUMAN | EF-hand calcium-binding domain-containing protein 4B (CRACR2A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00071 | Ras - Ras family | 547~705 | |
| PF13499 | EF-hand_7 - EF-hand domain pair | 54~113 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3666849 |  |
IC50 | = | 20.37 | nM | 390.34 | O=C(Nc1ccc(-n2nc(C(F)(F)F)cc2C2CC2)cc1)c1ccncc1F | Homo sapiens | CHEMBL3705678 | cell-based format |
| CHEMBL3666859 |  |
IC50 | = | 20.79 | nM | 394.33 | Cc1oncc1C(=O)Nc1ccc(-n2nc(C(F)(F)F)cc2C2CC2)c(F)c1 | Homo sapiens | CHEMBL3705678 | cell-based format |
| CHEMBL3666871 |  |
IC50 | = | 22.96 | nM | 386.38 | Cc1ccccc1C(=O)Nc1ccc(-n2nc(C(F)(F)F)cc2C2CC2)nc1 | Homo sapiens | CHEMBL3705678 | cell-based format |
| CHEMBL3666861 |  |
IC50 | = | 32.59 | nM | 425.33 | O=C(Nc1ccc(-n2nc(C(F)(F)F)cc2C2CC2)c(F)c1)c1cccc(F)c1F | Homo sapiens | CHEMBL3705678 | cell-based format |
| CHEMBL3666854 |  |
IC50 | = | 34.11 | nM | 392.41 | Cc1ncsc1NC(=O)c1ccc(-n2nc(C(F)(F)F)cc2C2CC2)cc1 | Homo sapiens | CHEMBL3705678 | cell-based format |
| CHEMBL3666857 |  |
IC50 | = | 35.72 | nM | 411.38 | Cc1nnsc1C(=O)Nc1ccc(-n2nc(C(F)(F)F)cc2C2CC2)c(F)c1 | Homo sapiens | CHEMBL3705678 | cell-based format |
| CHEMBL3666830 |  |
IC50 | = | 36.35 | nM | 357.46 | Cc1ccccc1C(=O)Nc1ccc(-n2nc(C3CC3)cc2C2CC2)cc1 | Homo sapiens | CHEMBL3705678 | cell-based format |
| CHEMBL3666877 |  |
IC50 | = | 37.58 | nM | 391.33 | O=C(Nc1ccc(-n2nc(C(F)(F)F)cc2C2CC2)nc1)c1ccncc1F | Homo sapiens | CHEMBL3705678 | cell-based format |
| CHEMBL3666875 |  |
IC50 | = | 47.21 | nM | 373.34 | O=C(Nc1ccc(-n2nc(C(F)(F)F)cc2C2CC2)nc1)c1cccnc1 | Homo sapiens | CHEMBL3705678 | cell-based format |
| CHEMBL3666852 |  |
IC50 | = | 48.02 | nM | 378.42 | Cc1ncsc1CNc1ccc(-n2nc(C(F)(F)F)cc2C2CC2)cc1 | Homo sapiens | CHEMBL3705678 | cell-based format |
| CHEMBL3666858 |  |
IC50 | = | 48.17 | nM | 410.4 | Cc1ncsc1C(=O)Nc1ccc(-n2nc(C(F)(F)F)cc2C2CC2)c(F)c1 | Homo sapiens | CHEMBL3705678 | cell-based format |
| CHEMBL3666851 |  |
IC50 | = | 48.22 | nM | 386.38 | O=C(Cc1cccnc1)Nc1ccc(-n2nc(C(F)(F)F)cc2C2CC2)cc1 | Homo sapiens | CHEMBL3705678 | cell-based format |
| CHEMBL3666874 |  |
IC50 | = | 50.58 | nM | 408.33 | O=C(Nc1ccc(-n2nc(C(F)(F)F)cc2C2CC2)nc1)c1c(F)cccc1F | Homo sapiens | CHEMBL3705678 | cell-based format |
| CHEMBL3666881 |  |
IC50 | = | 52.62 | nM | 402.35 | Cc1ncsc1C(=O)Nc1ccc(-n2nc(C(F)(F)F)cc2C(F)F)cc1 | Homo sapiens | CHEMBL3705678 | cell-based format |
| CHEMBL3666872 |  |
IC50 | = | 60.0 | nM | 390.34 | O=C(Nc1ccc(-n2nc(C(F)(F)F)cc2C2CC2)nc1)c1ccccc1F | Homo sapiens | CHEMBL3705678 | cell-based format |
| CHEMBL3639657 |  |
IC50 | = | 60.31 | nM | 383.45 | Cc1nnsc1C(=O)Nc1ccc(-n2nc(C3CC3)cc2C2CC2)c(F)c1 | Homo sapiens | CHEMBL3705678 | cell-based format |
| CHEMBL3666827 |  |
IC50 | = | 62.44 | nM | 365.46 | Cc1nnsc1C(=O)Nc1ccc(-n2nc(C3CC3)cc2C2CC2)cc1 | Homo sapiens | CHEMBL3705678 | cell-based format |
| CHEMBL3666876 |  |
IC50 | = | 62.56 | nM | 373.34 | O=C(Nc1ccc(-n2nc(C(F)(F)F)cc2C2CC2)nc1)c1ccncc1 | Homo sapiens | CHEMBL3705678 | cell-based format |
| CHEMBL3666845 |  |
IC50 | = | 63.17 | nM | 376.34 | Cc1oncc1C(=O)Nc1ccc(-n2nc(C(F)(F)F)cc2C2CC2)cc1 | Homo sapiens | CHEMBL3705678 | cell-based format |
| CHEMBL3666842 |  |
IC50 | = | 65.49 | nM | 441.24 | O=C(Nc1ccc(-n2nc(C(F)(F)F)cc2C2CC2)cc1)c1c(Cl)cncc1Cl | Homo sapiens | CHEMBL3705678 | cell-based format |