Q9BQI3 | E2AK1_HUMAN | Eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK1)

Pfam Domain Table

AccessionDomainRangeColor
PF00069Pkinase - Protein kinase domain168~239
PF00069Pkinase - Protein kinase domain369~583
PF22949HRI2_3H - Heme-regulated eIF-2-alpha kinase, helical domain63~141

3D structures mapped by conservation among orthologs


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL4281823 IC50 = 26.0 nM 481.48 CCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 Homo sapiens CHEMBL4261419 single protein format
CHEMBL2441342 IC50 = 37.0 nM 470.43 Cn1cc(-c2ccc3c(c2F)CCN3C(=O)Cc2cccc(C(F)(F)F)n2)c2c(N)ncnc21 Homo sapiens CHEMBL2443948 single protein format
CHEMBL2441346 IC50 = 61.0 nM 419.46 Cc1cc(C)n(CC(=O)N2CCc3c2ccc(-c2cn(C)c4ncnc(N)c24)c3F)n1 Homo sapiens CHEMBL2443948 single protein format
CHEMBL2171122 IC50 = 214.0 nM 417.9 Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(Cl)c2)c2c(N)ncnc21 Homo sapiens CHEMBL2172950 single protein format
CHEMBL2171124 IC50 = 420.0 nM 451.45 Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(C(F)(F)F)c2)c2c(N)ncnc21 Homo sapiens CHEMBL2172950 single protein format
CHEMBL2441340 IC50 = 460.0 nM 416.46 Cc1cccc(CC(=O)N2CCc3c2ccc(-c2cn(C)c4ncnc(N)c24)c3F)n1 Homo sapiens CHEMBL2443948 single protein format