Q99884 | SC6A7_HUMAN | Sodium-dependent proline transporter (SLC6A7)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00209 | SNF - Sodium:neurotransmitter symporter family | 37~560 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3318586 |  |
IC50 | = | 18.0 | nM | 404.9 | O=C(c1ccc(-c2cccc(Cl)c2)cc1)N1C2CCC1CN(c1ncccn1)C2 | Homo sapiens | CHEMBL3370229 | cell-based format |
| CHEMBL3318579 |  |
IC50 | = | 21.0 | nM | 392.89 | C[C@H]1CN(c2ncccn2)CCN1C(=O)c1ccc(-c2ccc(Cl)cc2)cc1 | Homo sapiens | CHEMBL3370229 | cell-based format |
| CHEMBL3318574 |  |
IC50 | = | 24.0 | nM | 406.92 | CC1CN(c2ncccn2)CC(C)N1C(=O)c1ccc(-c2cccc(Cl)c2)cc1 | Homo sapiens | CHEMBL3370229 | cell-based format |
| CHEMBL3318585 |  |
IC50 | = | 27.0 | nM | 404.9 | O=C(c1ccc(-c2cccc(Cl)c2)cc1)N1CC2CCC(C1)N2c1ncccn1 | Homo sapiens | CHEMBL3370229 | cell-based format |
| CHEMBL3318563 |  |
IC50 | = | 34.0 | nM | 364.47 | Cc1csc(-c2ccc(C(=O)N3CCN(c4ncccn4)CC3)cc2)c1 | Homo sapiens | CHEMBL3370229 | cell-based format |
| CHEMBL3318552 |  |
IC50 | = | 34.0 | nM | 358.45 | Cc1ccc(-c2ccc(C(=O)N3CCN(c4ncccn4)CC3)cc2)cc1 | Homo sapiens | CHEMBL3370229 | cell-based format |
| CHEMBL3318548 |  |
IC50 | = | 36.0 | nM | 378.86 | O=C(c1ccc(-c2cccc(Cl)c2)cc1)N1CCN(c2ncccn2)CC1 | Homo sapiens | CHEMBL3370229 | cell-based format |
| CHEMBL3318584 |  |
IC50 | = | 36.0 | nM | 404.9 | O=C(c1ccc(-c2cccc(Cl)c2)cc1)N1CC2CN(c3ncccn3)CC2C1 | Homo sapiens | CHEMBL3370229 | cell-based format |
| CHEMBL3317462 |  |
IC50 | = | 52.0 | nM | 378.86 | O=C(c1ccc(-c2ccc(Cl)cc2)cc1)N1CCN(c2ncccn2)CC1 | Homo sapiens | CHEMBL3370229 | cell-based format |
| CHEMBL3318573 |  |
IC50 | = | 53.0 | nM | 406.92 | CC1(C)CN(c2ncccn2)CCN1C(=O)c1ccc(-c2cccc(Cl)c2)cc1 | Homo sapiens | CHEMBL3370229 | cell-based format |
| CHEMBL3318580 |  |
IC50 | = | 57.0 | nM | 392.89 | C[C@@H]1CN(c2ncccn2)CCN1C(=O)c1ccc(-c2ccc(Cl)cc2)cc1 | Homo sapiens | CHEMBL3370229 | cell-based format |
| CHEMBL3318564 |  |
IC50 | = | 61.0 | nM | 364.47 | Cc1ccc(-c2ccc(C(=O)N3CCN(c4ncccn4)CC3)cc2)s1 | Homo sapiens | CHEMBL3370229 | cell-based format |
| CHEMBL3318549 |  |
IC50 | = | 71.0 | nM | 412.42 | O=C(c1ccc(-c2cccc(C(F)(F)F)c2)cc1)N1CCN(c2ncccn2)CC1 | Homo sapiens | CHEMBL3370229 | cell-based format |
| CHEMBL3318550 |  |
IC50 | = | 73.0 | nM | 428.41 | O=C(c1ccc(-c2cccc(OC(F)(F)F)c2)cc1)N1CCN(c2ncccn2)CC1 | Homo sapiens | CHEMBL3370229 | cell-based format |
| CHEMBL3318576 |  |
IC50 | = | 76.0 | nM | 408.89 | O=C(c1ccc(-c2cccc(Cl)c2)cc1)N1CCN(c2ncccn2)CC1CO | Homo sapiens | CHEMBL3370229 | cell-based format |
| CHEMBL3318554 |  |
IC50 | = | 76.0 | nM | 412.42 | O=C(c1ccc(-c2ccc(C(F)(F)F)cc2)cc1)N1CCN(c2ncccn2)CC1 | Homo sapiens | CHEMBL3370229 | cell-based format |
| CHEMBL3318553 |  |
IC50 | = | 77.0 | nM | 372.47 | CCc1ccc(-c2ccc(C(=O)N3CCN(c4ncccn4)CC3)cc2)cc1 | Homo sapiens | CHEMBL3370229 | cell-based format |
| CHEMBL3318581 |  |
IC50 | = | 89.0 | nM | 392.89 | O=C(c1ccc(-c2cccc(Cl)c2)cc1)N1CCCN(c2ncccn2)CC1 | Homo sapiens | CHEMBL3370229 | cell-based format |
| CHEMBL3318577 |  |
IC50 | = | 128.0 | nM | 422.87 | O=C(O)C1CN(c2ncccn2)CCN1C(=O)c1ccc(-c2cccc(Cl)c2)cc1 | Homo sapiens | CHEMBL3370229 | cell-based format |
| CHEMBL3318540 |  |
IC50 | = | 146.0 | nM | 349.46 | O=C(c1ccc(-c2ccccc2)cc1)N1CCN(c2nccs2)CC1 | Homo sapiens | CHEMBL3370229 | cell-based format |