Q99873 | ANM1_HUMAN | Protein arginine N-methyltransferase 1 (PRMT1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF13649 | Methyltransf_25 - Methyltransferase domain | 92~189 | |
| PF22528 | PRMT_C - Arginine methyltransferase oligomerization subdomain | 194~358 |
3D structures mapped by conservation among orthologs
[ Domain: "Arginine methyltransferase oligomerization subdomain" // PRMT5_C_1 ]
[ Domain: "S-adenosyl-L-methionine-dependent methyltransferases" // PrmA ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3589026 |  |
IC50 | = | 4.0 | nM | 288.4 | CC(C)Oc1ccc(-c2[nH]ncc2CN(C)CCN)cc1 | Homo sapiens | CHEMBL3591484 | cell-based format |
| CHEMBL3589030 |  |
IC50 | = | 4.0 | nM | 322.84 | CC(C)Oc1ccc(-c2[nH]ncc2CN(C)CCN)cc1Cl | Homo sapiens | CHEMBL3591484 | cell-based format |
| CHEMBL3901808 |  |
IC50 | = | 4.0 | nM | 287.41 | CC(C)Oc1ccc(-c2c[nH]cc2CN(C)CCN)cc1 | Homo sapiens | CHEMBL3859037 | single protein format |
| CHEMBL3589031 |  |
IC50 | = | 5.0 | nM | 336.87 | CNCCN(C)Cc1cn[nH]c1-c1ccc(OC(C)C)c(Cl)c1 | Homo sapiens | CHEMBL3591484 | cell-based format |
| CHEMBL3589028 |  |
IC50 | = | 5.0 | nM | 286.42 | CC(C)Cc1ccc(-c2[nH]ncc2CN(C)CCN)cc1 | Homo sapiens | CHEMBL3591484 | cell-based format |
| CHEMBL3589029 |  |
IC50 | = | 7.0 | nM | 322.41 | CN(CCN)Cc1cn[nH]c1-c1ccc(Oc2ccccc2)cc1 | Homo sapiens | CHEMBL3591484 | cell-based format |
| CHEMBL3589027 |  |
IC50 | = | 7.0 | nM | 302.42 | CNCCN(C)Cc1cn[nH]c1-c1ccc(OC(C)C)cc1 | Homo sapiens | CHEMBL3591484 | cell-based format |
| CHEMBL3589036 |  |
IC50 | = | 8.0 | nM | 432.49 | CNCCN(C)Cc1cn[nH]c1-c1cc(OCCc2ccccc2)cc(C(F)(F)F)c1 | Homo sapiens | CHEMBL3591484 | cell-based format |
| CHEMBL3589913 |  |
IC50 | = | 13.0 | nM | 288.4 | CCOc1ccc(-c2[nH]ncc2CN(C)CCNC)cc1 | Homo sapiens | CHEMBL3591484 | cell-based format |
| CHEMBL3589033 |  |
IC50 | = | 13.0 | nM | 332.45 | CCC(CO)Oc1ccc(-c2[nH]ncc2CN(C)CCNC)cc1 | Homo sapiens | CHEMBL3591484 | cell-based format |
| CHEMBL3589032 |  |
IC50 | = | 14.0 | nM | 350.89 | CNCCN(C)Cc1cnn(C)c1-c1ccc(OC(C)C)c(Cl)c1 | Homo sapiens | CHEMBL3591484 | cell-based format |
| CHEMBL3589037 |  |
IC50 | = | 14.0 | nM | 438.54 | CNCCN(C)Cc1cn[nH]c1-c1cc(OCCC2CCCCC2)cc(C(F)(F)F)c1 | Homo sapiens | CHEMBL3591484 | cell-based format |
| CHEMBL3589038 |  |
IC50 | = | 16.0 | nM | 428.5 | CNCCN(C)Cc1cn[nH]c1-c1cc(OC(CO)CC(C)C)cc(C(F)(F)F)c1 | Homo sapiens | CHEMBL3591484 | cell-based format |
| CHEMBL3589912 |  |
IC50 | = | 18.0 | nM | 248.31 | CN(CCN)Cc1cn[nH]c1-c1ccc(F)cc1 | Homo sapiens | CHEMBL3591484 | cell-based format |
| CHEMBL3589042 |  |
IC50 | = | 26.0 | nM | 407.52 | CNCCN(C)Cc1c[nH]nc1-c1ccc(Oc2cccc(C(=O)N(C)C)c2)cc1 | Homo sapiens | CHEMBL3591484 | cell-based format |
| CHEMBL3589034 |  |
IC50 | = | 27.0 | nM | 346.48 | CNCCN(C)Cc1cn[nH]c1-c1ccc(OC(CO)C(C)C)cc1 | Homo sapiens | CHEMBL3591484 | cell-based format |
| CHEMBL4518534 |  |
IC50 | = | 31.0 | nM | 418.84 | OC1CN=C2c3ccn([C@@H]4O[C@H]([C@H](O)c5ccc(Cl)cc5)[C@@H](O)[C@H]4O)c3N=CN21 | Homo sapiens | CHEMBL4307076 | single protein format |
| CHEMBL3589035 |  |
IC50 | = | 43.0 | nM | 390.84 | CC(C)Oc1c(Cl)cc(-c2c[nH]nc2CN(C)CCN)cc1C(F)(F)F | Homo sapiens | CHEMBL3591484 | cell-based format |
| CHEMBL3590417 |  |
IC50 | = | 50.0 | nM | 393.49 | CNCCN(C)Cc1n[nH]cc1-c1ccc(Oc2ccccc2C(=O)NC)cc1 | Homo sapiens | CHEMBL3591484 | cell-based format |
| CHEMBL3589043 |  |
IC50 | = | 60.0 | nM | 407.52 | CNCCN(C)Cc1n[nH]cc1-c1ccc(Oc2cccc(C(=O)N(C)C)c2)cc1 | Homo sapiens | CHEMBL3591484 | cell-based format |