Q99720 | SGMR1_HUMAN | Sigma non-opioid intracellular receptor 1 (SIGMAR1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF04622 | ERG2_Sigma1R - ERG2 and Sigma1 receptor like protein | 15~215 |
3D structures mapped by conservation among orthologs
[ Domain: "Double-stranded beta-helix" // ERG2_Sigma1R ]
[ Domain: "Transmembrane helix of sigma-1 receptor" // KOG4143_like ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2023825 |  |
IC50 | = | 0.27 | nM | 468.73 | c1ccc(C(c2ccc(N3CCN(C4CCCCC4)CC3)cc2)C23CC4CC(CC(C4)C2)C3)cc1 | Homo sapiens | CHEMBL2026918 | cell-based format |
| CHEMBL545477 |  |
IC50 | = | 0.29 | nM | 338.28 | CN(C)[C@H]1Cc2cc(Cl)c(O)cc2[C@H](c2ccccc2)C1.Cl | Homo sapiens | CHEMBL803752 | tissue-based format |
| CHEMBL129452 |  |
IC50 | = | 0.5 | nM | 325.84 | O=C(CCN1CC=C(c2ccc(Cl)cc2)CC1)c1ccccc1 | Homo sapiens | CHEMBL846480 | tissue-based format |
| CHEMBL346409 |  |
IC50 | = | 0.5 | nM | 322.5 | c1ccc(CCCN2CCN(CCCc3ccccc3)CC2)cc1 | Homo sapiens | CHEMBL847754 | single protein format |
| CHEMBL542167 |  |
IC50 | = | 0.51 | nM | 301.86 | CN(C)[C@@]1(C)Cc2ccccc2[C@H](c2ccccc2)C1.Cl | Homo sapiens | CHEMBL803752 | tissue-based format |
| CHEMBL193805 |  |
IC50 | = | 0.9 | nM | 329.47 | O=C1[C@@H]2Cc3ccccc3CN2C(=S)N1CCN1CCCCC1 | Homo sapiens | CHEMBL880593 | tissue-based format |
| CHEMBL521582 |  |
IC50 | = | 1.3 | nM | 391.98 | CCCN(CCC)CCc1ccc(OC)c(OCCc2ccccc2)c1.Cl | Homo sapiens | CHEMBL809837 | assay format |
| CHEMBL545249 |  |
IC50 | = | 1.4 | nM | 338.28 | CN(C)C1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1.Cl | Homo sapiens | CHEMBL803752 | tissue-based format |
| CHEMBL553962 |  |
IC50 | = | 1.5 | nM | 420.04 | CCCCCC(Cc1ccc(OC)c(OCCc2ccccc2)c1)NCCC.Cl | Homo sapiens | CHEMBL809837 | assay format |
| CHEMBL540331 |  |
IC50 | = | 1.8 | nM | 420.04 | CCCNC(CCC(C)C)Cc1ccc(OC)c(OCCc2ccccc2)c1.Cl | Homo sapiens | CHEMBL809837 | assay format |
| CHEMBL2303661 |  |
IC50 | = | 2.0 | nM | 355.35 | CN(CCc1ccc(Cl)c(Cl)c1)C1CCCCC1N1CCCC1 | Homo sapiens | CHEMBL803878 | single protein format |
| CHEMBL128860 |  |
IC50 | = | 2.1 | nM | 369.55 | CCCCC(Cc1ccc(OC)c(OCCc2ccccc2)c1)NCCC | Homo sapiens | CHEMBL809837 | assay format |
| CHEMBL365786 |  |
IC50 | = | 2.1 | nM | 377.49 | CN(CCCN1C(=O)[C@@H]2Cc3ccccc3CN2C1=O)CCc1ccccc1 | Homo sapiens | CHEMBL881479 | tissue-based format |
| CHEMBL193699 |  |
IC50 | = | 2.4 | nM | 375.47 | O=C1[C@@H]2Cc3ccccc3CN2C(=O)N1C1CCN(Cc2ccccc2)CC1 | Homo sapiens | CHEMBL880587 | tissue-based format |
| CHEMBL299499 |  |
IC50 | = | 2.8 | nM | 395.29 | N=C(Nc1ccc(I)cc1)NC12CC3CC(CC(C3)C1)C2 | Homo sapiens | CHEMBL804880 | assay format |
| CHEMBL194738 |  |
IC50 | = | 2.9 | nM | 405.54 | CN(CCCCCc1ccccc1)CCN1C(=O)[C@@H]2Cc3ccccc3CN2C1=O | Homo sapiens | CHEMBL881479 | tissue-based format |
| CHEMBL2023824 |  |
IC50 | = | 2.9 | nM | 414.64 | CCN1CCN(c2ccc(C(c3ccccc3)C34CC5CC(CC(C5)C3)C4)cc2)CC1 | Homo sapiens | CHEMBL2026918 | cell-based format |
| CHEMBL2204672 |  |
IC50 | = | 2.9 | nM | 428.66 | CN1CCN(CCc2ccc(C(c3ccccc3)C34CC5CC(CC(C5)C3)C4)cc2)CC1 | Homo sapiens | CHEMBL2210027 | cell-based format |
| CHEMBL2023823 |  |
IC50 | = | 3.2 | nM | 400.61 | CN1CCN(c2ccc(C(c3ccccc3)C34CC5CC(CC(C5)C3)C4)cc2)CC1 | Homo sapiens | CHEMBL2026918 | cell-based format |
| CHEMBL194687 |  |
IC50 | = | 3.2 | nM | 391.52 | CN(CCCCc1ccccc1)CCN1C(=O)[C@@H]2Cc3ccccc3CN2C1=O | Homo sapiens | CHEMBL881479 | tissue-based format |