Q99707 | METH_HUMAN | Methionine synthase (MTR)
Helixβ‑strandTurn secondary structure
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00809 | Pterin_bind | 375–613 | |
| PF02310 | B12-binding | 774–866 | |
| PF02574 | S-methyl_trans | 31–338 | |
| PF02607 | B12-binding_2 | 671–747 | |
| PF02965 | Met_synt_B12 | 965–1246 |
3D structures mapped by conservation among orthologs
[ Domain: "Methionine synthase activation domain-like" // Met_synt_B12 ]
[ Domain: "TIM barrels" // Pterin_bind ]
[ Domain: "TIM barrels" // S-methyl_trans ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL34259 |  |
IC50 | = | 0.0 | nM | 454.45 | CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1 | Homo sapiens | CHEMBL4768027 | cell-based format |
| CHEMBL27364 |  |
IC50 | = | 2.2 | nM | 410.56 | O=C1c2ccccc2CN1C1CCN(CCC(c2ccccc2)c2ccccc2)CC1 | Homo sapiens | CHEMBL5331969 | single protein format |