Q99705 | MCHR1_HUMAN | Melanin-concentrating hormone receptor 1 (MCHR1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 57~311 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL468099 |  |
IC50 | = | 0.09 | nM | 531.55 | O=C(C(c1ccc(F)c(F)c1)n1cccn1)N(CCF)CCCN1CCC2(CC1)OCc1cc(F)ncc12 | Homo sapiens | CHEMBL969605 | cell-based format |
| CHEMBL214322 |  |
IC50 | = | 0.1 | nM | 494.54 | Cc1cc(Oc2ccc(C(=O)NCCN3CCCC3)cc2NC(=O)Nc2cccc(F)c2)ccc1F | Homo sapiens | CHEMBL863645 | cell-based format |
| CHEMBL250516 |  |
IC50 | = | 0.1 | nM | 381.55 | COc1ccc2c(C)cc(N[C@H]3CCC[C@H](NCc4ccsc4)C3)nc2c1 | Homo sapiens | CHEMBL888238 | cell-based format |
| CHEMBL568571 |  |
IC50 | = | 0.12 | nM | 481.52 | CCO/N=C(/c1ccc(CN2CCC3(CC2)OCc2cc(F)ncc23)cc1)c1ccc(F)c(F)c1 | Homo sapiens | CHEMBL1039121 | cell-based format |
| CHEMBL511542 |  |
IC50 | = | 0.15 | nM | 513.56 | CCN(CCCN1CCC2(CC1)OCc1cc(F)ncc12)C(=O)C(c1ccc(F)c(F)c1)n1cccn1 | Homo sapiens | CHEMBL969605 | cell-based format |
| CHEMBL176219 |  |
IC50 | = | 0.17 | nM | 533.5 | N#Cc1cccc(-c2ccc(C3(CNC(=O)Nc4cc(Cl)cc(Cl)c4)CCN(CC4CC4)CC3)cc2)c1 | Homo sapiens | CHEMBL4410510 | cell-based format |
| CHEMBL566880 |  |
IC50 | = | 0.22 | nM | 467.49 | CO/N=C(/c1ccc(CN2CCC3(CC2)OCc2cc(F)ncc23)cc1)c1ccc(F)c(F)c1 | Homo sapiens | CHEMBL1039121 | cell-based format |
| CHEMBL582978 |  |
IC50 | = | 0.26 | nM | 453.46 | O/N=C(/c1ccc(CN2CCC3(CC2)OCc2cc(F)ncc23)cc1)c1ccc(F)c(F)c1 | Homo sapiens | CHEMBL1039121 | cell-based format |
| CHEMBL439358 |  |
IC50 | = | 0.3 | nM | 413.44 | CC(C)(C)c1cc(N)c2cc(NC(=O)/C=C/c3ccc(C(F)(F)F)cc3)ccc2n1 | Homo sapiens | CHEMBL856552 | single protein format |
| CHEMBL412831 |  |
IC50 | = | 0.3 | nM | 413.44 | CCC(C)c1cc(N)c2cc(NC(=O)/C=C/c3ccc(C(F)(F)F)cc3)ccc2n1 | Homo sapiens | CHEMBL856552 | single protein format |
| CHEMBL176159 |  |
IC50 | = | 0.31 | nM | 521.49 | CCCN1CCC(CNC(=O)Nc2cc(Cl)cc(Cl)c2)(c2ccc(-c3cccc(C#N)c3)cc2)CC1 | Homo sapiens | CHEMBL4410510 | cell-based format |
| CHEMBL582792 |  |
IC50 | = | 0.35 | nM | 482.51 | CCO/N=C(/c1ccc(F)c(F)c1)c1ccc(CN2CCC3(CC2)OCc2cc(F)ncc23)cn1 | Homo sapiens | CHEMBL1039121 | cell-based format |
| CHEMBL2031736 |  |
IC50 | = | 0.36 | nM | 455.99 | Cc1c(NC(=O)c2ccc(-c3ccc(Cl)cc3)cc2)ccc2cc(CN3CCCC3)cnc12 | Homo sapiens | CHEMBL2033452 | cell-based format |
| CHEMBL182261 |  |
IC50 | = | 0.4 | nM | 355.83 | Nc1ccc2cccc(OCCCNC(=O)c3cccc(Cl)c3)c2n1 | Homo sapiens | CHEMBL832324 | cell-based format |
| CHEMBL178997 |  |
IC50 | = | 0.41 | nM | 537.49 | COCCN1CCC(CNC(=O)Nc2cc(Cl)cc(Cl)c2)(c2ccc(-c3cccc(C#N)c3)cc2)CC1 | Homo sapiens | CHEMBL4410510 | cell-based format |
| CHEMBL217502 |  |
IC50 | = | 0.5 | nM | 468.52 | O=C(CCc1ccc(C(F)(F)F)cc1)Nc1ccc2nc(N3CCC4(CCNC4)C3)ccc2c1 | Homo sapiens | CHEMBL856555 | single protein format |
| CHEMBL1922270 |  |
IC50 | = | 0.5 | nM | 434.55 | C[C@H]1c2c([nH]c3ccc(C(F)(F)F)cc23)C[C@H]2CCN(CCCC3CCOCC3)C[C@@H]21 | Homo sapiens | CHEMBL1924587 | single protein format |
| CHEMBL2031734 |  |
IC50 | = | 0.53 | nM | 451.57 | COc1ccc(-c2ccc(C(=O)Nc3ccc4cc(CN5CCCC5)cnc4c3C)cc2)cc1 | Homo sapiens | CHEMBL2033452 | cell-based format |
| CHEMBL2029372 |  |
IC50 | = | 0.54 | nM | 439.53 | Cc1c(NC(=O)c2ccc(-c3ccc(F)cc3)cc2)ccc2cc(CN3CCCC3)cnc12 | Homo sapiens | CHEMBL2033452 | cell-based format |
| CHEMBL1224229 |  |
IC50 | = | 0.6 | nM | 484.62 | CC(=O)Nc1cccc(C2CCN(CCCCc3nc4ccccc4n3-c3ccc(F)cc3)CC2)c1 | Homo sapiens | CHEMBL1228974 | cell-based format |