Q99683 | M3K5_HUMAN | Mitogen-activated protein kinase kinase kinase 5 (MAP3K5)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 685~937 | |
| PF13281 | MAP3K_TRAF_bd - MAP3K TRAFs-binding domain | 165~545 | |
| PF19039 | ASK_PH - ASK kinase PH domain | 556~653 | |
| PF20302 | HisK-N-like - HisK-N-like globin domain of the ASK signalosome | 1042~1173 | |
| PF20309 | DRHyd-ASK - Deoxyribohydrolase (DRHyd) domain of the ASK signalosome | 115~150 |
3D structures mapped by conservation among orthologs
[ Domain: "PH domain-like" // KOG4279 ]
[ Domain: "ARM repeat" // DUF4071 ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4283739 |  |
IC50 | = | 0.1 | nM | 430.49 | COc1cc(C)c(S(N)(=O)=O)cc1C(=O)Nc1cccc(-c2nncn2C(C)C)n1 | Homo sapiens | CHEMBL4255094 | assay format |
| CHEMBL4290518 |  |
IC50 | = | 0.32 | nM | 444.52 | CCS(=O)(=O)Nc1ccc(OC)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)c1 | Homo sapiens | CHEMBL4255094 | assay format |
| CHEMBL4294318 |  |
IC50 | = | 0.42 | nM | 394.44 | COc1cc(C)c(C(N)=O)cc1C(=O)Nc1cccc(-c2nncn2C(C)C)n1 | Homo sapiens | CHEMBL4255094 | assay format |
| CHEMBL4083562 |  |
IC50 | = | 0.7 | nM | 557.61 | CC(n1cnnc1-c1nc(NC(=O)c2cc(-n3cnc(C4CC4)c3)c(N3CCCCC3)cn2)cs1)C(F)(F)F | Homo sapiens | CHEMBL4024899 | single protein format |
| CHEMBL3683270 |  |
IC50 | = | 0.7 | nM | 557.61 | C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(-n3cnc(C4CC4)c3)c(N3CCCCC3)cn2)cs1)C(F)(F)F | Homo sapiens | CHEMBL3705386 | single protein format |
| CHEMBL4282644 |  |
IC50 | = | 1.0 | nM | 380.41 | COc1ccc(C(N)=O)cc1C(=O)Nc1cccc(-c2nncn2C(C)C)n1 | Homo sapiens | CHEMBL4255094 | assay format |
| CHEMBL4868362 |  |
IC50 | = | 1.0 | nM | 407.36 | COc1nn(C)cc1C(=O)Nc1cccc(-c2nncn2C2(C(F)(F)F)CC2)n1 | Homo sapiens | CHEMBL4845477 | single protein format |
| CHEMBL3683259 |  |
IC50 | = | 1.44 | nM | 503.59 | O=C(Nc1csc(-c2nncn2C2CC2)n1)c1cc(-n2cnc(C3CC3)c2)c(N2CCOCC2)cn1 | Homo sapiens | CHEMBL3705386 | single protein format |
| CHEMBL3683260 |  |
IC50 | = | 1.58 | nM | 503.59 | CC1(O)CN(c2cnc(C(=O)Nc3csc(-c4nncn4C4CC4)n3)cc2-n2cnc(C3CC3)c2)C1 | Homo sapiens | CHEMBL3705386 | single protein format |
| CHEMBL3683262 |  |
IC50 | = | 1.69 | nM | 559.58 | C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(-n3cnc(C4CC4)c3)c(N3CC(C)(O)C3)cn2)cs1)C(F)(F)F | Homo sapiens | CHEMBL3705386 | single protein format |
| CHEMBL3683265 |  |
IC50 | = | 1.7 | nM | 529.55 | C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(-n3cnc(C4CC4)c3)c(N3CCC3)cn2)cs1)C(F)(F)F | Homo sapiens | CHEMBL3705386 | single protein format |
| CHEMBL5424950 |  |
IC50 | = | 1.73 | nM | 536.57 | O=C(Nc1cccc(-c2nncn2C2CC2)n1)c1cc(-c2cnn(C3CC3)c2)cn(Cc2ccccc2F)c1=O | Homo sapiens | CHEMBL5356322 | single protein format |
| CHEMBL3687971 |  |
IC50 | = | 1.8 | nM | 587.63 | C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(-n3cnc(C4CC4)c3)c(N3CCC(C)(O)CC3)cn2)cs1)C(F)(F)F | Homo sapiens | CHEMBL3705386 | single protein format |
| CHEMBL3683263 |  |
IC50 | = | 1.88 | nM | 517.54 | C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(-n3cnc(C4CC4)c3)c(N(C)C)cn2)cs1)C(F)(F)F | Homo sapiens | CHEMBL3705386 | single protein format |
| CHEMBL3683267 |  |
IC50 | = | 1.9 | nM | 487.59 | O=C(Nc1csc(-c2nncn2C2CC2)n1)c1cc(-n2cnc(C3CC3)c2)c(N2CCCC2)cn1 | Homo sapiens | CHEMBL3705386 | single protein format |
| CHEMBL4634900 |  |
IC50 | = | 1.9 | nM | 447.5 | COc1nn(-c2cncc(N(C)C)c2)cc1C(=O)Nc1cccc(-c2nncn2C(C)C)n1 | Homo sapiens | CHEMBL4605628 | single protein format |
| CHEMBL3644048 |  |
IC50 | = | 2.0 | nM | 430.3 | C[C@](O)(CO)c1ccc(C(=O)Nc2cc3c(cn2)c(Br)cn3C2CC2)cc1 | Homo sapiens | CHEMBL3705518 | single protein format |
| CHEMBL4871543 |  |
IC50 | = | 2.0 | nM | 435.41 | COc1nn(CC2CC2)cc1C(=O)Nc1cccc(-c2nncn2[C@@H](C)C(F)(F)F)n1 | Homo sapiens | CHEMBL4845477 | single protein format |
| CHEMBL4850048 |  |
IC50 | = | 2.0 | nM | 439.4 | COCCn1cc(C(=O)Nc2cccc(-c3nncn3[C@@H](C)C(F)(F)F)n2)c(OC)n1 | Homo sapiens | CHEMBL4845477 | single protein format |
| CHEMBL4857751 |  |
IC50 | = | 2.0 | nM | 409.37 | CCn1cc(C(=O)Nc2cccc(-c3nncn3[C@@H](C)C(F)(F)F)n2)c(OC)n1 | Homo sapiens | CHEMBL4845477 | single protein format |