Q99640 | PMYT1_HUMAN | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 111~357 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5198360 |  |
IC50 | = | 4.0 | nM | 372.39 | Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2nc3cccc(C#N)c3nc21 | Homo sapiens | CHEMBL5141600 | assay format |
| CHEMBL5172086 |  |
IC50 | = | 4.0 | nM | 427.47 | Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2nc3cc(-c4ccnn4C)ccc3nc21 | Homo sapiens | CHEMBL5141600 | assay format |
| CHEMBL5191665 |  |
IC50 | = | 5.0 | nM | 367.8 | Cc1ccc(O)c(Cl)c1-n1c(N)c(C(N)=O)c2nc3ccccc3nc21 | Homo sapiens | CHEMBL5141600 | assay format |
| CHEMBL5190904 |  |
IC50 | = | 5.0 | nM | 336.4 | Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cc(C3CC3)cnc21 | Homo sapiens | CHEMBL5141607 | cell-based format |
| CHEMBL5187022 |  |
IC50 | = | 5.0 | nM | 372.39 | Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2nc3cc(C#N)ccc3nc21 | Homo sapiens | CHEMBL5141600 | assay format |
| CHEMBL5195417 |  |
IC50 | = | 5.0 | nM | 426.27 | Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2nc3ccc(Br)cc3nc21 | Homo sapiens | CHEMBL5141600 | assay format |
| CHEMBL5199806 |  |
IC50 | = | 5.0 | nM | 372.39 | Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2nc3c(C#N)cccc3nc21 | Homo sapiens | CHEMBL5141600 | assay format |
| CHEMBL5184178 |  |
IC50 | = | 5.0 | nM | 413.48 | Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2nc3cc(C4=CCCC4)ccc3nc21 | Homo sapiens | CHEMBL5141600 | assay format |
| CHEMBL5196095 |  |
IC50 | = | 6.0 | nM | 427.47 | Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2nc3c(-c4ccnn4C)cccc3nc21 | Homo sapiens | CHEMBL5141600 | assay format |
| CHEMBL5416410 |  |
IC50 | = | 6.0 | nM | 506.03 | Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1.O | Homo sapiens | CHEMBL4233136 | cell-based format |
| CHEMBL4583196 |  |
IC50 | = | 6.0 | nM | 473.99 | Cc1nc(Nc2ncc(C(=O)Nc3ccccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 | Homo sapiens | CHEMBL4328727 | single protein format |
| CHEMBL49120 |  |
IC50 | = | 7.0 | nM | 512.44 | CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 | Homo sapiens | CHEMBL1948658 | single protein format |
| CHEMBL5174072 |  |
IC50 | = | 7.0 | nM | 344.8 | Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cc(Cl)c(C)nc21 | Homo sapiens | CHEMBL5141607 | cell-based format |
| CHEMBL5202826 |  |
IC50 | = | 8.0 | nM | 347.38 | Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2nc3ccccc3nc21 | Homo sapiens | CHEMBL5141600 | assay format |
| CHEMBL5176413 |  |
IC50 | = | 8.0 | nM | 413.48 | Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2nc3c(C4=CCCC4)cccc3nc21 | Homo sapiens | CHEMBL5141600 | assay format |
| CHEMBL5177087 |  |
IC50 | = | 8.0 | nM | 388.21 | NC(=O)c1c(N)n(-c2c(Cl)ccc(O)c2Cl)c2nc3ccccc3nc12 | Homo sapiens | CHEMBL5141600 | assay format |
| CHEMBL5193896 |  |
IC50 | = | 10.0 | nM | 333.35 | Cc1c(O)cccc1-n1c(N)c(C(N)=O)c2nc3ccccc3nc21 | Homo sapiens | CHEMBL5141600 | assay format |
| CHEMBL5202444 |  |
IC50 | = | 10.0 | nM | 367.8 | Cc1c(O)ccc(Cl)c1-n1c(N)c(C(N)=O)c2nc3ccccc3nc21 | Homo sapiens | CHEMBL5141600 | assay format |
| CHEMBL5184635 |  |
IC50 | = | 11.0 | nM | 332.36 | Cc1ccc(O)c(C)c1-n1cc(C(N)=O)c2nc3ccccc3nc21 | Homo sapiens | CHEMBL5141600 | assay format |
| CHEMBL5203261 |  |
IC50 | = | 12.0 | nM | 332.36 | Cc1ccc(O)cc1-n1c(N)c(C(N)=O)c2cc3ccccc3nc21 | Homo sapiens | CHEMBL5141600 | assay format |