Q99572 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00864 | P2X_receptor - ATP P2X receptor | 11~389 | |
| PF20478 | P2RX7_C - P2X purinoreceptor 7 intracellular domain | 400~592 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2324343 |  |
IC50 | = | 0.01 | nM | 435.42 | Cc1ccc2c(=O)n([C@H](C)CN)ccc2c1NC(=O)Cc1ccc(C(F)(F)F)c(F)c1 | Homo sapiens | CHEMBL2327433 | single protein format |
| CHEMBL4165149 |  |
IC50 | = | 0.11 | nM | 581.7 | CN(C)c1ccc(C(=O)N2CCC(n3cncc3-c3ccc(OS(=O)(=O)c4cccc5cnccc45)cc3)CC2)cc1 | Homo sapiens | CHEMBL4153246 | cell-based format |
| CHEMBL5430904 |  |
IC50 | = | 0.15 | nM | 394.52 | C[C@@H](CO)n1ccc2c(NC(=O)CC34CC5CC(CC(C5)C3)C4)cccc2c1=O | Homo sapiens | CHEMBL5361610 | single protein format |
| CHEMBL3663243 |  |
IC50 | = | 0.2 | nM | 438.81 | C[C@H]1Cn2c(nnc2-c2ccc(F)cc2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl | Homo sapiens | CHEMBL3749873 | cell-based format |
| CHEMBL3663257 |  |
IC50 | = | 0.2 | nM | 427.84 | C[C@H]1Cn2c(nnc2-c2cscn2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl | Homo sapiens | CHEMBL3706110 | cell-based format |
| CHEMBL3679011 |  |
IC50 | = | 0.28 | nM | 417.26 | O=C(NCC1(c2ccc(F)nc2)CCC(F)(F)CC1)c1cccc(Cl)c1Cl | Homo sapiens | CHEMBL3705577 | cell-based format |
| CHEMBL3663294 |  |
IC50 | = | 0.3 | nM | 436.83 | CC[C@H]1Cn2c(nnc2-c2ncccn2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl | Homo sapiens | CHEMBL3706110 | cell-based format |
| CHEMBL3984958 |  |
IC50 | = | 0.33 | nM | 431.29 | O=C(NCC(c1ccc(F)cc1)N1CCC(F)(F)CC1)c1cccc(Cl)c1Cl | Homo sapiens | CHEMBL3888912 | cell-based format |
| CHEMBL3663316 |  |
IC50 | = | 0.4 | nM | 422.8 | C[C@H]1Cn2c(nnc2-c2ncccn2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl | Homo sapiens | CHEMBL3706110 | cell-based format |
| CHEMBL3663244 |  |
IC50 | = | 0.5 | nM | 421.81 | C[C@H]1Cn2c(nnc2-c2ccccn2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl | Homo sapiens | CHEMBL3749873 | cell-based format |
| CHEMBL3955749 |  |
IC50 | = | 0.53 | nM | 393.31 | Cc1cccc(C(=O)NC[C@H](c2ccc(Cl)cc2)N2CCOCC2)c1Cl | Homo sapiens | CHEMBL3888912 | cell-based format |
| CHEMBL3679043 |  |
IC50 | = | 0.54 | nM | 446.85 | Cc1cccc(C(=O)NCC2(c3ccc(C(F)(F)F)nc3)CCC(F)(F)CC2)c1Cl | Homo sapiens | CHEMBL3705577 | cell-based format |
| CHEMBL3679036 |  |
IC50 | = | 0.55 | nM | 417.26 | O=C(NCC(CC1CC1)c1ccc(C(F)(F)F)nc1)c1cccc(Cl)c1Cl | Homo sapiens | CHEMBL3705577 | cell-based format |
| CHEMBL3913134 |  |
IC50 | = | 0.6 | nM | 443.32 | COc1ccc(C(CNC(=O)c2cccc(Cl)c2Cl)N2CCC(F)(F)CC2)cc1 | Homo sapiens | CHEMBL3888912 | cell-based format |
| CHEMBL3916032 |  |
IC50 | = | 0.6 | nM | 413.73 | O=C(NCC(c1ccc(Cl)cc1)N1CCOCC1)c1cccc(Cl)c1Cl | Homo sapiens | CHEMBL3888912 | cell-based format |
| CHEMBL3958103 |  |
IC50 | = | 0.62 | nM | 465.83 | O=C(NCC(c1ccc(C(F)(F)F)nc1)N1CCC(F)(F)CC1)c1c(F)cccc1Cl | Homo sapiens | CHEMBL3888912 | cell-based format |
| CHEMBL4109892 |  |
IC50 | = | 0.62 | nM | 413.73 | O=C(NC[C@H](c1ccc(Cl)cc1)N1CCOCC1)c1cccc(Cl)c1Cl | Homo sapiens | CHEMBL3888912 | cell-based format |
| CHEMBL3913344 |  |
IC50 | = | 0.65 | nM | 483.27 | O=C(NCC(c1cnc(C(F)(F)F)nc1)N1CCC(F)(F)CC1)c1cccc(Cl)c1Cl | Homo sapiens | CHEMBL3888912 | cell-based format |
| CHEMBL3663260 |  |
IC50 | = | 0.7 | nM | 451.84 | C[C@H]1Cn2c(nnc2-c2cc(CO)ccn2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl | Homo sapiens | CHEMBL3706110 | cell-based format |
| CHEMBL3663242 |  |
IC50 | = | 0.7 | nM | 422.8 | C[C@H]1Cn2c(nnc2-c2cnccn2)C(=O)N1Cc1cccc(C(F)(F)F)c1Cl | Homo sapiens | CHEMBL3706110 | cell-based format |