Q99571 | P2RX4_HUMAN | P2X purinoceptor 4 (P2RX4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00864 | P2X_receptor - ATP P2X receptor | 13~373 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4471140 |  |
IC50 | = | 2.0 | nM | 430.91 | NS(=O)(=O)c1cc(NC(=O)Cc2ccccc2Cl)ccc1OCc1ccccc1 | Homo sapiens | CHEMBL4324752 | cell-based format |
| CHEMBL4452312 |  |
IC50 | = | 2.0 | nM | 446.91 | COc1ccccc1CC(=O)Nc1ccc(Oc2cccc(Cl)c2)c(S(N)(=O)=O)c1 | Homo sapiens | CHEMBL4324752 | cell-based format |
| CHEMBL4589444 |  |
IC50 | = | 5.0 | nM | 408.91 | NS(=O)(=O)c1cc(NC(=O)Cc2ccccc2Cl)ccc1OCC1CCC1 | Homo sapiens | CHEMBL4324752 | cell-based format |
| CHEMBL4579583 |  |
IC50 | = | 8.0 | nM | 446.91 | COc1cccc(Oc2ccc(NC(=O)Cc3ccccc3Cl)cc2S(N)(=O)=O)c1 | Homo sapiens | CHEMBL4324752 | cell-based format |
| CHEMBL4447043 |  |
IC50 | = | 9.0 | nM | 469.32 | NS(=O)(=O)c1cc(NC(=O)Cc2c(F)cccc2Cl)ccc1Oc1cccc(Cl)c1 | Homo sapiens | CHEMBL4324752 | cell-based format |
| CHEMBL4522504 |  |
IC50 | = | 10.0 | nM | 430.91 | Cc1ccccc1CC(=O)Nc1ccc(Oc2cccc(Cl)c2)c(S(N)(=O)=O)c1 | Homo sapiens | CHEMBL4324752 | cell-based format |
| CHEMBL4556573 |  |
IC50 | = | 10.0 | nM | 416.89 | NS(=O)(=O)c1cc(NC(=O)Cc2ccccc2Cl)ccc1Oc1ccccc1 | Homo sapiens | CHEMBL4324752 | cell-based format |
| CHEMBL4555657 |  |
IC50 | = | 13.0 | nM | 456.92 | NS(=O)(=O)c1cc(NC(=O)Cc2c(F)cccc2Cl)ccc1OCC1CCOCC1 | Homo sapiens | CHEMBL4324752 | cell-based format |
| CHEMBL4516176 |  |
IC50 | = | 13.0 | nM | 451.33 | NS(=O)(=O)c1cc(NC(=O)Cc2ccccc2Cl)ccc1Oc1ccccc1Cl | Homo sapiens | CHEMBL4324752 | cell-based format |
| CHEMBL4521017 |  |
IC50 | = | 15.0 | nM | 485.78 | NS(=O)(=O)c1cc(NC(=O)Cc2c(Cl)cccc2Cl)ccc1Oc1cccc(Cl)c1 | Homo sapiens | CHEMBL4324752 | cell-based format |
| CHEMBL4563994 |  |
IC50 | = | 19.0 | nM | 444.94 | NS(=O)(=O)c1cc(NC(=O)Cc2ccccc2Cl)ccc1OCCc1ccccc1 | Homo sapiens | CHEMBL4324752 | cell-based format |
| CHEMBL4438327 |  |
IC50 | = | 24.0 | nM | 484.88 | NS(=O)(=O)c1cc(NC(=O)Cc2ccccc2C(F)(F)F)ccc1Oc1cccc(Cl)c1 | Homo sapiens | CHEMBL4324752 | cell-based format |
| CHEMBL4439570 |  |
IC50 | = | 26.0 | nM | 431.9 | NS(=O)(=O)c1cc(NC(=O)Cc2ccccc2Cl)ccc1OCc1ccccn1 | Homo sapiens | CHEMBL4324752 | cell-based format |
| CHEMBL4535761 |  |
IC50 | = | 27.0 | nM | 452.32 | NS(=O)(=O)c1cc(NC(=O)Cc2ccccc2Cl)ccc1Oc1cncc(Cl)c1 | Homo sapiens | CHEMBL4324752 | cell-based format |
| CHEMBL4463320 |  |
IC50 | = | 30.0 | nM | 500.0 | NS(=O)(=O)c1cc(NC(=O)Cc2ccccc2Cl)ccc1Oc1ccc(-c2nccs2)cc1 | Homo sapiens | CHEMBL4324752 | cell-based format |
| CHEMBL4517831 |  |
IC50 | = | 37.0 | nM | 456.92 | NS(=O)(=O)c1cc(NC(=O)Cc2cccc(F)c2Cl)ccc1OCC1CCOCC1 | Homo sapiens | CHEMBL4324752 | cell-based format |
| CHEMBL4539658 |  |
IC50 | = | 39.0 | nM | 422.93 | NS(=O)(=O)c1cc(NC(=O)Cc2ccccc2Cl)ccc1OC1CCCCC1 | Homo sapiens | CHEMBL4324752 | cell-based format |
| CHEMBL5206892 |  |
IC50 | = | 39.0 | nM | 421.32 | CC(C)c1ccc(NC(=S)NC(=O)c2ccc3c(c2)OCO3)c(Br)c1 | Homo sapiens | CHEMBL5140232 | cell-based format |
| CHEMBL5204261 |  |
IC50 | = | 40.0 | nM | 435.43 | CC(C)c1ccc(NC(=S)NC(=O)C23CC4CC(CC(C4)C2)C3)c(Br)c1 | Homo sapiens | CHEMBL5134953 | cell-based format |
| CHEMBL4640175 |  |
IC50 | = | 42.6 | nM | 360.68 | O=C(Nc1cc([N+](=O)[O-])cc(C(F)(F)F)c1)c1cc(Cl)ccc1O | Homo sapiens | CHEMBL4615161 | cell-based format |