Q99558 | M3K14_HUMAN | Mitogen-activated protein kinase kinase kinase 14 (MAP3K14)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 405~646 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4211563 |  |
IC50 | = | 1.2 | nM | 414.44 | Cc1ccc(C#N)cc1Nc1ncc(F)c(-c2cc(C#N)c3c(c2)[C@@](C)(CO)CN3)n1 | Homo sapiens | CHEMBL4194323 | single protein format |
| CHEMBL4216964 |  |
IC50 | = | 1.3 | nM | 509.61 | Cc1cc(CCN2CCOCC2)c(C#N)cc1Nc1nccc(-c2cc(C#N)c3c(c2)[C@@](C)(CO)CN3)n1 | Homo sapiens | CHEMBL4194323 | single protein format |
| CHEMBL4206684 |  |
IC50 | = | 2.2 | nM | 403.48 | [2H]C([2H])(O)c1ccc(C)c(Nc2nccc(-c3cc(C#N)c4c(c3)[C@@](C)(CO)CN4)n2)c1 | Homo sapiens | CHEMBL4194323 | single protein format |
| CHEMBL4218285 |  |
IC50 | = | 2.2 | nM | 428.5 | CNC(=O)c1ccc(C)c(Nc2nccc(-c3cc(C#N)c4c(c3)[C@@](C)(CO)CN4)n2)c1 | Homo sapiens | CHEMBL4194323 | single protein format |
| CHEMBL4552922 |  |
IC50 | = | 4.2 | nM | 397.89 | C[C@@](O)(C#Cc1ccc2c(c1)N(c1nc(N)ncc1Cl)CC2)c1nccs1 | Homo sapiens | CHEMBL4405672 | single protein format |
| CHEMBL3187788 |  |
IC50 | = | 4.7 | nM | 397.89 | CC(O)(C#Cc1ccc2c(c1)N(c1nc(N)ncc1Cl)CC2)c1nccs1 | Homo sapiens | CHEMBL4618345 | assay format |
| CHEMBL4205698 |  |
IC50 | = | 4.7 | nM | 404.43 | COc1ccc2c(-c3cccc(C#C[C@]4(O)CCN(C)C4=O)c3)nc(C(N)=O)n2c1 | Homo sapiens | CHEMBL4195749 | cell-based format |
| CHEMBL4793033 |  |
IC50 | = | 5.2 | nM | 433.54 | COCCN(C)c1cc(-c2cn[nH]c2)c2cc(C#CC(C)(O)c3nccs3)ccc2n1 | Homo sapiens | CHEMBL4677596 | assay format |
| CHEMBL4448524 |  |
IC50 | = | 5.9 | nM | 365.37 | CN1CCC(O)(C#Cc2ccc(F)c(-c3c[nH]c4cnc(N)nc34)c2)C1=O | Homo sapiens | CHEMBL4405673 | cell-based format |
| CHEMBL4216017 |  |
IC50 | = | 6.0 | nM | 414.44 | Cc1cc(F)c(C#N)cc1Nc1nccc(-c2cc(C#N)c3c(c2)[C@@](C)(CO)CN3)n1 | Homo sapiens | CHEMBL4194323 | single protein format |
| CHEMBL4218937 |  |
IC50 | = | 6.3 | nM | 412.45 | C[C@]1(CO)CNc2c(C#N)cc(-c3ccnc(Nc4cc(C#N)ccc4CO)n3)cc21 | Homo sapiens | CHEMBL4194323 | single protein format |
| CHEMBL4648033 |  |
IC50 | = | 6.59 | nM | 445.55 | CC(O)(C#Cc1ccc(N2CCOCC2)c(Nc2ccnc3[nH]ccc23)c1)c1nccs1 | Homo sapiens | CHEMBL4618345 | assay format |
| CHEMBL4202865 |  |
IC50 | = | 6.6 | nM | 445.52 | CC(C)Oc1ccc(CO)cc1Nc1nccc(-c2cc(C#N)c3c(c2)[C@@](C)(CO)CN3)n1 | Homo sapiens | CHEMBL4194323 | single protein format |
| CHEMBL4207209 |  |
IC50 | = | 7.8 | nM | 419.46 | Cc1cc(F)c(CO)cc1Nc1nccc(-c2cc(C#N)c3c(c2)[C@@](C)(CO)CN3)n1 | Homo sapiens | CHEMBL4194323 | single protein format |
| CHEMBL4644825 |  |
IC50 | = | 8.22 | nM | 537.67 | CCS(=O)(=O)N1CCN(c2ccc(C#CC(C)(O)c3nccs3)cc2Nc2ncnc3[nH]ccc23)CC1 | Homo sapiens | CHEMBL4618345 | assay format |
| CHEMBL4642561 |  |
IC50 | = | 8.63 | nM | 447.52 | CC(O)(C#Cc1ccc(N2CCOCC2)c(Nc2ncnc3[nH]ncc23)c1)c1nccs1 | Homo sapiens | CHEMBL4618345 | assay format |
| CHEMBL4445719 |  |
IC50 | = | 9.1 | nM | 379.42 | C[C@@](O)(C#Cc1ccc(F)c(-c2c[nH]c3cnc(N)nc23)c1)c1nccs1 | Homo sapiens | CHEMBL4405673 | cell-based format |
| CHEMBL4645565 |  |
IC50 | = | 9.87 | nM | 446.54 | CC(O)(C#Cc1ccc(N2CCOCC2)c(Nc2ncnc3[nH]ccc23)c1)c1nccs1 | Homo sapiens | CHEMBL4618345 | assay format |
| CHEMBL4215425 |  |
IC50 | = | 10.0 | nM | 385.42 | CN1CC[C@@](O)(C#Cc2cccc(-c3cc4ccccc4c(C(N)=O)n3)c2)C1=O | Homo sapiens | CHEMBL4195749 | cell-based format |
| CHEMBL4643621 |  |
IC50 | = | 11.4 | nM | 422.51 | CC(O)(C#Cc1ccc(N2CCOCC2)c(Nc2ccnc(N)n2)c1)c1nccs1 | Homo sapiens | CHEMBL4618345 | assay format |