Q99523 | SORT_HUMAN | Sortilin (SORT1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF15901 | Sortilin_C - Sortilin, neurotensin receptor 3, C-terminal | 575~740 | |
| PF15902 | Sortilin-Vps10 - Sortilin, neurotensin receptor 3, | 142~572 |
3D structures mapped by conservation among orthologs
[ Domain: "10-bladed" // Sortilin-Vps10 ]
[ Domain: "Sortilin C-terminal domain" // Sortilin_C_2nd ]
[ Domain: "Sortilin C-terminal domain" // Sortilin_C_1st ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3098768 |  |
IC50 | = | 100.0 | nM | 364.32 | O=C(O)c1cc(C(F)(F)F)ccc1C(=O)Nc1ccc2c(n1)CCCC2 | Homo sapiens | CHEMBL3100581 | single protein format |
| CHEMBL3098767 |  |
IC50 | = | 170.0 | nM | 338.29 | Cc1ccc(NC(=O)c2ccc(C(F)(F)F)cc2C(=O)O)nc1C | Homo sapiens | CHEMBL3100581 | single protein format |
| CHEMBL506981 |  |
IC50 | = | 238.0 | nM | 587.08 | COc1cccc(OC)c1-c1cc(C(=O)NC2(C(=O)O)C3CC4CC(C3)CC2C4)nn1-c1ccnc2cc(Cl)ccc12 | Homo sapiens | CHEMBL2405877 | single protein format |
| CHEMBL3098745 |  |
IC50 | = | 330.0 | nM | 324.26 | Cc1cccc(NC(=O)c2ccc(C(F)(F)F)cc2C(=O)O)n1 | Homo sapiens | CHEMBL3100581 | single protein format |
| CHEMBL1852155 |  |
IC50 | = | 380.0 | nM | 581.8 | C=C1CN(S(=O)(=O)c2ccc(C)cc2)CCCN(Cc2ccccc2)CCCN(S(=O)(=O)c2ccc(C)cc2)C1 | Homo sapiens | CHEMBL4629041 | cell-based format |
| CHEMBL3098765 |  |
IC50 | = | 490.0 | nM | 336.15 | Cc1nccc(NC(=O)c2ccc(Br)cc2C(=O)O)n1 | Homo sapiens | CHEMBL3100581 | single protein format |
| CHEMBL3098741 |  |
IC50 | = | 710.0 | nM | 335.16 | Cc1cccc(NC(=O)c2ccc(Br)cc2C(=O)O)n1 | Homo sapiens | CHEMBL3100581 | single protein format |
| CHEMBL3098752 |  |
IC50 | = | 830.0 | nM | 325.15 | Cc1cccc(NC(=O)c2cc(Cl)c(Cl)cc2C(=O)O)n1 | Homo sapiens | CHEMBL3100581 | single protein format |