ProtHub

Q99466 | NOTC4_HUMAN | Neurogenic locus notch homolog protein 4 (NOTCH4)

Helixβ‑strandTurn secondary structure

Accession	Domain	Range
PF00008	EGF	28–60
PF00008	EGF	160–188
PF00008	EGF	238–271
PF00008	EGF	280–308
PF00008	EGF	444–471
PF00008	EGF	479–507
PF00008	EGF	555–585
PF00008	EGF	593–622
PF00008	EGF	733–762
PF00008	EGF	771–801
PF00008	EGF	810–838
PF00008	EGF	901–925
PF00008	EGF	934–963
PF00008	EGF	972–1002
PF00008	EGF	1050–1083
PF00023	Ank	1768–1796
PF00066	Notch	1168–1204
PF00066	Notch	1211–1246
PF00066	Notch	1249–1285
PF06816	NOD	1297–1344
PF07645	EGF_CA	194–227
PF07645	EGF_CA	314–348
PF07684	NODP	1379–1436
PF12661	hEGF	127–149
PF12661	hEGF	364–384
PF12661	hEGF	522–543
PF12661	hEGF	700–721
PF12796	Ank_2	1630–1689
PF12796	Ank_2	1695–1764

3D structures mapped by conservation among orthologs

[ Alpha Fold Model ] (go)

Known binders annotated in ChEMBL

Only the first 20 rows are shown.

molecule_chembl_id	structure	assay_type	relation	value	unit	mol_wt	smiles	organism	assay_chembl_id	bao_label
CHEMBL3410161		IC50	=	3.0	nM	536.55	CN1C(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccccc2)N=C(c2ccccc2)c2ccccc21	Homo sapiens	CHEMBL3412056	cell-based format