Q99466 | NOTC4_HUMAN | Neurogenic locus notch homolog protein 4 (NOTCH4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00008 | EGF - EGF-like domain | 28~60 | |
| PF00008 | EGF - EGF-like domain | 160~188 | |
| PF00008 | EGF - EGF-like domain | 238~271 | |
| PF00008 | EGF - EGF-like domain | 280~308 | |
| PF00008 | EGF - EGF-like domain | 444~471 | |
| PF00008 | EGF - EGF-like domain | 479~507 | |
| PF00008 | EGF - EGF-like domain | 555~585 | |
| PF00008 | EGF - EGF-like domain | 593~622 | |
| PF00008 | EGF - EGF-like domain | 733~762 | |
| PF00008 | EGF - EGF-like domain | 771~801 | |
| PF00008 | EGF - EGF-like domain | 810~838 | |
| PF00008 | EGF - EGF-like domain | 901~925 | |
| PF00008 | EGF - EGF-like domain | 934~963 | |
| PF00008 | EGF - EGF-like domain | 972~1002 | |
| PF00008 | EGF - EGF-like domain | 1050~1083 | |
| PF00023 | Ank - Ankyrin repeat | 1768~1796 | |
| PF00066 | Notch - LNR domain | 1168~1204 | |
| PF00066 | Notch - LNR domain | 1211~1246 | |
| PF00066 | Notch - LNR domain | 1249~1285 | |
| PF06816 | NOD - NOTCH protein | 1297~1344 | |
| PF07645 | EGF_CA - Calcium-binding EGF domain | 194~227 | |
| PF07645 | EGF_CA - Calcium-binding EGF domain | 314~348 | |
| PF07684 | NODP - NOTCH protein | 1379~1436 | |
| PF12661 | hEGF - Human growth factor-like EGF | 127~149 | |
| PF12661 | hEGF - Human growth factor-like EGF | 364~384 | |
| PF12661 | hEGF - Human growth factor-like EGF | 522~543 | |
| PF12661 | hEGF - Human growth factor-like EGF | 700~721 | |
| PF12796 | Ank_2 - Ankyrin repeats (3 copies) | 1630~1689 | |
| PF12796 | Ank_2 - Ankyrin repeats (3 copies) | 1695~1764 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3410161 |  |
IC50 | = | 3.0 | nM | 536.55 | CN1C(=O)[C@@H](NC(=O)[C@H](CCC(F)(F)F)[C@@H](C(N)=O)c2ccccc2)N=C(c2ccccc2)c2ccccc21 | Homo sapiens | CHEMBL3412056 | cell-based format |