Q99250 | SCN2A_HUMAN | Sodium channel protein type 2 subunit alpha (SCN2A)

Pfam Domain Table

AccessionDomainRangeColor
PF00520Ion_trans - Ion transport protein128~434
PF00520Ion_trans - Ion transport protein759~990
PF00520Ion_trans - Ion transport protein1207~1482
PF00520Ion_trans - Ion transport protein1531~1786
PF06512Na_trans_assoc - Sodium ion transport-associated997~1203
PF11933Na_trans_cytopl - Cytoplasmic domain of voltage-gated Na+ ion channel558~709
PF24609IQ_SCN5A_C - SCN5A-like, C-terminal IQ motif1898~1930

3D structures mapped by conservation among orthologs

[ Domain: "EF-hand" // EF-hand_7_6 ]

 PyMOL session

[ Domain: "Voltage-gated ion channels" // Ion_trans ]

 PyMOL session

[ Domain: "Voltage gated calcium channel IQ domain" // IQ_like ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL3617050 IC50 = 0.0061 nM 552.48 N=C1N[C@@]23[C@H]([C@H]4NC(=N)N2C[C@](OS(=O)(=O)O)(C[C@H]2[C@@H](CO)CON2C4=O)C3(O)O)N1COC(=O)NO Homo sapiens CHEMBL3618797 cell-based format
CHEMBL3617063 IC50 = 0.2 nM 534.96 Nc1nc2cc(-c3cc(Cl)ccc3Oc3cc(F)c(S(=O)(=O)Nc4ncns4)cc3F)ccc2[nH]1 Homo sapiens CHEMBL3806745 cell-based format
CHEMBL4060338 IC50 = 0.45 nM 295.47 CCCCCCCCCC[C@@H]1C[C@]2(CCCO2)NC(=N)N1 Homo sapiens CHEMBL3999227 cell-based format
CHEMBL501134 IC50 = 1.0 nM 299.29 N=C1N[C@H]2[C@H](COC(N)=O)NC(=N)N3CCC(O)(O)[C@]23N1 Homo sapiens CHEMBL4321992 cell-based format
CHEMBL3662190 IC50 = 2.0 nM 435.56 CC1(COc2cc(F)c(C(=O)NS(=O)(=O)C3CC3)cc2C2CC2)CCC2(CC1)CC2 Homo sapiens CHEMBL4321992 cell-based format
CHEMBL4070670 IC50 = 2.1 nM 295.47 CCCCCCCCCC[C@H]1C[C@@]2(CCCO2)NC(=N)N1 Homo sapiens CHEMBL3999227 cell-based format
CHEMBL3341983 IC50 = 4.2 nM 535.94 Nc1noc2ccc(-c3cc(Cl)ccc3Oc3cc(F)c(S(=O)(=O)Nc4ncns4)cc3F)cc12 Homo sapiens CHEMBL3806745 cell-based format
CHEMBL3662077 IC50 = 6.0 nM 445.5 CC1(COc2cc(F)c(C(=O)NS(=O)(=O)C3CC3)cc2C2CC2)CCC(F)(F)CC1 Homo sapiens CHEMBL5264215 cell-based format
CHEMBL4290579 IC50 = 7.0 nM 442.59 O=S(=O)(Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(C3CC3)cn12)C1CC1 Homo sapiens CHEMBL4256590 cell-based format
CHEMBL4082248 IC50 = 7.5 nM 339.48 CCCCCCCCCC[C@@H]1NC(=N)N[C@]2(CCCO2)[C@@H]1C(=O)O Homo sapiens CHEMBL3999227 cell-based format
CHEMBL4285790 IC50 = 10.0 nM 427.31 CS(=O)(=O)Nc1nnc2cc(COc3cc(Cl)cc(Cl)c3)c(C3CC3)cn12 Homo sapiens CHEMBL4256590 cell-based format
CHEMBL4279238 IC50 = 14.0 nM 416.55 CS(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(C3CC3)cn12 Homo sapiens CHEMBL4256590 cell-based format
CHEMBL507974 IC50 = 14.0 nM 319.27 NC1=N[C@H](O)[C@H]2[C@H]3O[C@]4(O)O[C@@H]([C@@H](O)[C@@]2(N1)[C@@H]4O)[C@]3(O)CO Homo sapiens CHEMBL4321992 cell-based format
CHEMBL3657855 IC50 = 20.0 nM 462.59 O=C(NS(=O)(=O)N1CCC1)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F Homo sapiens CHEMBL4321992 cell-based format
CHEMBL4064160 IC50 = 26.0 nM 339.48 CCCCCCCCCC[C@H]1NC(=N)N[C@@]2(CCCO2)[C@H]1C(=O)O Homo sapiens CHEMBL3999227 cell-based format
CHEMBL5094715 IC50 = 38.0 nM 543.49 C[C@@H](c1cc(Cl)cc(Cl)c1)N1CCC(COc2cc(F)c(C(=O)NS(C)(=O)=O)cc2C2CC2)CC1 Homo sapiens CHEMBL5055699 cell-based format
CHEMBL1269990 IC50 = 50.0 nM 405.93 O=C(NCc1ccccc1N1CCCCC1)c1cncc(-c2ccc(Cl)cc2)c1 Homo sapiens CHEMBL1272889 single protein format
CHEMBL1270301 IC50 = 70.0 nM 406.92 O=C(NCc1cccnc1N1CCCCC1)c1cncc(-c2ccc(Cl)cc2)c1 Homo sapiens CHEMBL1272889 single protein format
CHEMBL486495 IC50 = 100.0 nM 394.56 CC(C)(C)c1ccc(-c2ccc(C(=O)N3CCN(C4CCCCC4)CC3)o2)cc1 Homo sapiens CHEMBL954008 cell-based format
CHEMBL2325014 IC50 = 110.0 nM 500.36 Nc1[nH]ncc1-c1cc(Cl)ccc1Oc1cc(F)c(S(=O)(=O)Nc2cscn2)cc1Cl Homo sapiens CHEMBL4321992 cell-based format