Q96T53 | MBOA4_HUMAN | Ghrelin O-acyltransferase (MBOAT4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF03062 | MBOAT - MBOAT, membrane-bound O-acyltransferase family | 109~388 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4793203 |  |
IC50 | = | 0.02 | nM | 321.34 | Cc1nc2nonc2c(N)c1Cc1ccc(C#N)c(NC2CC2)n1 | Homo sapiens | CHEMBL4673674 | cell-based format |
| CHEMBL4746798 |  |
IC50 | = | 0.028 | nM | 375.31 | Cc1nc2nonc2c(N)c1Cn1ccc(-c2cccc(C(F)(F)F)n2)n1 | Homo sapiens | CHEMBL4673674 | cell-based format |
| CHEMBL4754865 |  |
IC50 | = | 0.066 | nM | 338.29 | COc1cc(C(F)(F)F)ccc1Cc1c(C)nc2nonc2c1N | Homo sapiens | CHEMBL4673674 | cell-based format |
| CHEMBL4781133 |  |
IC50 | = | 0.13 | nM | 385.17 | Cc1nc2ncnn2c(N)c1Cc1ccc(Br)c(OC(F)F)n1 | Homo sapiens | CHEMBL4673674 | cell-based format |
| CHEMBL4789143 |  |
IC50 | = | 0.56 | nM | 331.3 | Cc1nc2nonc2c(N)c1CN1CCC(OC(F)(F)F)CC1 | Homo sapiens | CHEMBL4673674 | cell-based format |
| CHEMBL4785875 |  |
IC50 | = | 1.7 | nM | 450.26 | Cc1nc(C(F)(F)F)ccc1COc1cc(Cl)c2cc(CC(=O)O)sc2c1Cl | Homo sapiens | CHEMBL4673668 | microsome format |
| CHEMBL4791105 |  |
IC50 | = | 8.6 | nM | 354.21 | O=C(O)c1ccc2oc(SCc3ccc(Cl)cc3Cl)nc2c1 | Homo sapiens | CHEMBL4673668 | microsome format |
| CHEMBL4764363 |  |
IC50 | < | 50.0 | nM | 359.83 | O=C(O)Cc1csc2cc(O[C@H]3CCc4ncccc43)cc(Cl)c12 | Homo sapiens | CHEMBL4673673 | cell membrane format |
| CHEMBL5094891 |  |
IC50 | < | 50.0 | nM | 373.86 | Cc1ccc2c(n1)CC[C@@H]2Oc1cc(Cl)c2c(CC(=O)O)csc2c1 | Homo sapiens | CHEMBL5053172 | assay format |
| CHEMBL5079256 |  |
IC50 | < | 50.0 | nM | 384.84 | N#Cc1ccc2c(n1)CCC2Oc1cc(Cl)c2c(CC(=O)O)csc2c1 | Homo sapiens | CHEMBL5053172 | assay format |
| CHEMBL5083870 |  |
IC50 | < | 50.0 | nM | 361.81 | O=C(O)Cc1csc2cc(O[C@@H]3COc4ncccc43)cc(Cl)c12 | Homo sapiens | CHEMBL5053172 | assay format |
| CHEMBL5076025 |  |
IC50 | < | 50.0 | nM | 396.25 | O=C(O)Cc1csc2c(Cl)c(O[C@@H]3COc4ncccc43)cc(Cl)c12 | Homo sapiens | CHEMBL5053172 | assay format |
| CHEMBL5089563 |  |
IC50 | < | 50.0 | nM | 361.81 | O=C(O)Cc1csc2cc(O[C@H]3COc4ncccc43)cc(Cl)c12 | Homo sapiens | CHEMBL5053172 | assay format |
| CHEMBL5092553 |  |
IC50 | < | 50.0 | nM | 447.79 | O=C(O)Cc1csc2c(F)c(O[C@@H]3COc4nc(C(F)(F)F)ccc43)cc(Cl)c12 | Homo sapiens | CHEMBL5053172 | assay format |
| CHEMBL5083866 |  |
IC50 | < | 50.0 | nM | 462.28 | O=C(O)Cc1csc2c(Cl)c(O[C@@H]3CCc4nc(C(F)(F)F)ccc43)cc(Cl)c12 | Homo sapiens | CHEMBL5053172 | assay format |
| CHEMBL5093321 |  |
IC50 | < | 50.0 | nM | 428.72 | O=C(O)Cc1csc2c(Cl)c(O[C@@H]3CCc4nc(Cl)ccc43)cc(Cl)c12 | Homo sapiens | CHEMBL5053172 | assay format |
| CHEMBL5079075 |  |
IC50 | < | 50.0 | nM | 402.86 | NC(=O)c1ccc2c(n1)CC[C@H]2Oc1cc(Cl)c2c(CC(=O)O)csc2c1 | Homo sapiens | CHEMBL5053172 | assay format |
| CHEMBL4741187 |  |
IC50 | = | 54.4 | nM | 433.94 | Cc1nc(Cl)nc(N)c1CCC1CCN(C(=O)[C@H](C)NC(=O)c2cn[nH]c2C)CC1 | Homo sapiens | CHEMBL4673662 | cell membrane format |
| CHEMBL4741216 |  |
IC50 | = | 68.9 | nM | 434.93 | C[C@H](NC(=O)c1ccn(C)n1)C(=O)N1CCC(CCc2c(N)nc(N)nc2Cl)CC1 | Homo sapiens | CHEMBL4673662 | cell membrane format |
| CHEMBL4756266 |  |
IC50 | = | 69.5 | nM | 467.5 | Cc1nc(C(F)(F)F)nc(N)c1CCC1CCN(C(=O)[C@H](C)NC(=O)c2ccnn2C)CC1 | Homo sapiens | CHEMBL4673662 | cell membrane format |