Q96SW2 | CRBN_HUMAN | Protein cereblon (CRBN)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF02190 | LON_substr_bdg - ATP-dependent protease La (LON) substrate-binding domain | 81~317 | |
| PF03226 | Yippee-Mis18 - Yippee zinc-binding/DNA-binding /Mis18, centromere assembly | 321~432 |
3D structures mapped by conservation among orthologs
[ Domain: "PUA domain" // LON_substr_bdg ]
[ Domain: "Mss4-like" // Yippee-Mis18_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5279477 |  |
IC50 | = | 1.1 | nM | 326.31 | O=C1CCC(N2Cc3ccc(S(=O)(=O)F)cc3C2=O)C(=O)N1 | Homo sapiens | CHEMBL5375575 | cell-based format |
| CHEMBL5431754 |  |
IC50 | = | 21.1 | nM | 375.37 | O=C1CCC(N2Cc3ccc(S(=O)(=O)n4nccn4)cc3C2=O)C(=O)N1 | Homo sapiens | CHEMBL5375575 | cell-based format |
| CHEMBL5439475 |  |
IC50 | = | 41.9 | nM | 374.38 | O=C1CCC(N2Cc3ccc(S(=O)(=O)n4ccnc4)cc3C2=O)C(=O)N1 | Homo sapiens | CHEMBL5375575 | cell-based format |
| CHEMBL5430120 |  |
IC50 | = | 43.6 | nM | 442.38 | O=C1CCC(N2Cc3ccc(S(=O)(=O)n4cc(C(F)(F)F)cn4)cc3C2=O)C(=O)N1 | Homo sapiens | CHEMBL5375575 | cell-based format |
| CHEMBL5419977 |  |
IC50 | = | 50.4 | nM | 442.38 | O=C1CCC(N2Cc3ccc(S(=O)(=O)n4ccc(C(F)(F)F)n4)cc3C2=O)C(=O)N1 | Homo sapiens | CHEMBL5375575 | cell-based format |
| CHEMBL5431074 |  |
IC50 | = | 54.9 | nM | 442.38 | O=C1CCC(N2Cc3ccc(S(=O)(=O)n4cnc(C(F)(F)F)c4)cc3C2=O)C(=O)N1 | Homo sapiens | CHEMBL5375575 | cell-based format |
| CHEMBL3989927 |  |
IC50 | = | 60.0 | nM | 449.51 | O=C1CC[C@H](N2Cc3c(OCc4ccc(CN5CCOCC5)cc4)cccc3C2=O)C(=O)N1 | Homo sapiens | CHEMBL4219431 | cell-based format |
| CHEMBL5431003 |  |
IC50 | = | 71.0 | nM | 312.32 | O=C1CCC(N2Cc3ccc(S(=O)(=O)F)cc3C2)C(=O)N1 | Homo sapiens | CHEMBL5380587 | cell-based format |
| CHEMBL5420894 |  |
IC50 | = | 77.9 | nM | 375.37 | O=C1CCC(N2Cc3ccc(S(=O)(=O)n4cncn4)cc3C2=O)C(=O)N1 | Homo sapiens | CHEMBL5375575 | cell-based format |
| CHEMBL2324726 |  |
IC50 | = | 234.0 | nM | 260.25 | O=C1CCC(N2Cc3c(O)cccc3C2=O)C(=O)N1 | Homo sapiens | CHEMBL5256274 | single protein format |
| CHEMBL5289875 |  |
IC50 | = | 255.0 | nM | 342.3 | O=C1CCC(N2Cc3ccc(OS(=O)(=O)F)cc3C2=O)C(=O)N1 | Homo sapiens | CHEMBL5375575 | cell-based format |
| CHEMBL5429393 |  |
IC50 | = | 324.0 | nM | 392.37 | O=C1CCC(N2Cc3ccc(S(=O)(=O)n4cnc(F)c4)cc3C2=O)C(=O)N1 | Homo sapiens | CHEMBL5375575 | cell-based format |
| CHEMBL2324704 |  |
IC50 | = | 337.0 | nM | 260.25 | O=C1CCC(N2Cc3cccc(O)c3C2=O)C(=O)N1 | Homo sapiens | CHEMBL5256274 | single protein format |
| CHEMBL182442 |  |
IC50 | = | 376.0 | nM | 274.23 | O=C1CCC(N2C(=O)c3ccc(O)cc3C2=O)C(=O)N1 | Homo sapiens | CHEMBL5256274 | single protein format |
| CHEMBL40206 |  |
IC50 | = | 382.0 | nM | 259.26 | Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O | Homo sapiens | CHEMBL5256274 | single protein format |
| CHEMBL848 |  |
IC50 | = | 390.0 | nM | 259.26 | Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O | Homo sapiens | CHEMBL5256274 | single protein format |
| CHEMBL5399248 |  |
IC50 | = | 454.0 | nM | 388.41 | Cc1cn(S(=O)(=O)c2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3)cn1 | Homo sapiens | CHEMBL5375575 | cell-based format |
| CHEMBL43855 |  |
IC50 | = | 560.0 | nM | 273.25 | Nc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O | Homo sapiens | CHEMBL5256274 | single protein format |
| CHEMBL304572 |  |
IC50 | = | 605.0 | nM | 244.25 | O=C1CCC(N2Cc3ccccc3C2=O)C(=O)N1 | Homo sapiens | CHEMBL5256274 | single protein format |
| CHEMBL2324714 |  |
IC50 | = | 630.0 | nM | 274.23 | O=C1CCC(N2C(=O)c3cccc(O)c3C2=O)C(=O)N1 | Homo sapiens | CHEMBL5256274 | single protein format |