Q96SB4 | SRPK1_HUMAN | SRSF protein kinase 1 (SRPK1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 80~228 | |
| PF00069 | Pkinase - Protein kinase domain | 489~653 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5074274 |  |
IC50 | = | 6.0 | nM | 507.52 | O=C(Nc1cc(C(F)(F)F)ccc1N1CCN(Cc2ccccn2)CC1)c1ccc(-c2ccncc2)o1 | Homo sapiens | CHEMBL5105886 | single protein format |
| CHEMBL5439515 |  |
IC50 | = | 7.0 | nM | 461.91 | CN(c1ncccc1CNc1ccnc(-c2nc3cc(Cl)cc(F)c3[nH]2)n1)S(C)(=O)=O | Homo sapiens | CHEMBL5321354 | single protein format |
| CHEMBL5397100 |  |
IC50 | = | 15.0 | nM | 442.93 | CN(c1ncccc1CNc1cccc(-c2nc3cc(Cl)ccc3[nH]2)n1)S(C)(=O)=O | Homo sapiens | CHEMBL5321354 | single protein format |
| CHEMBL5416930 |  |
IC50 | = | 15.0 | nM | 467.94 | CN(c1ncccc1Cn1ccc2cnc(-c3nc4cc(Cl)ccc4[nH]3)nc21)S(C)(=O)=O | Homo sapiens | CHEMBL5321354 | single protein format |
| CHEMBL5409896 |  |
IC50 | = | 16.0 | nM | 522.82 | CN(c1ncccc1CNc1nc(-c2nc3cc(Cl)ccc3[nH]2)ncc1Br)S(C)(=O)=O | Homo sapiens | CHEMBL5321354 | single protein format |
| CHEMBL5422948 |  |
IC50 | = | 18.0 | nM | 445.46 | CN(c1ncccc1CNc1ccnc(-c2nc3cc(F)cc(F)c3[nH]2)n1)S(C)(=O)=O | Homo sapiens | CHEMBL5321354 | single protein format |
| CHEMBL5398076 |  |
IC50 | = | 22.0 | nM | 461.91 | CN(c1ncccc1CNc1ccnc(-c2nc3cc(F)cc(Cl)c3[nH]2)n1)S(C)(=O)=O | Homo sapiens | CHEMBL5321354 | single protein format |
| CHEMBL5409387 |  |
IC50 | = | 24.0 | nM | 457.95 | CN(Cc1cccnc1N(C)S(C)(=O)=O)c1ccnc(-c2nc3cc(Cl)ccc3[nH]2)n1 | Homo sapiens | CHEMBL5321354 | single protein format |
| CHEMBL5416263 |  |
IC50 | = | 24.0 | nM | 445.46 | CN(c1ncccc1CNc1ccnc(-c2nc3cc(F)c(F)cc3[nH]2)n1)S(C)(=O)=O | Homo sapiens | CHEMBL5321354 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 24.5 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328610 | single protein format |
| CHEMBL5403164 |  |
IC50 | = | 31.0 | nM | 489.57 | CN(c1ncccc1CNc1ccnc(-c2nc3cc(-c4cnn(C)c4)ccc3[nH]2)n1)S(C)(=O)=O | Homo sapiens | CHEMBL5321354 | single protein format |
| CHEMBL5399262 |  |
IC50 | = | 32.0 | nM | 461.91 | CN(c1ncccc1CNc1ccnc(-c2nc3cc(Cl)c(F)cc3[nH]2)n1)S(C)(=O)=O | Homo sapiens | CHEMBL5321354 | single protein format |
| CHEMBL5407046 |  |
IC50 | = | 32.0 | nM | 443.92 | CN(c1ncccc1CNc1ccnc(-c2nc3cc(Cl)ccc3[nH]2)n1)S(C)(=O)=O | Homo sapiens | CHEMBL5321354 | single protein format |
| CHEMBL5437009 |  |
IC50 | = | 35.0 | nM | 481.97 | Cc1cc2cnc(-c3nc4cc(Cl)ccc4[nH]3)nc2n1Cc1cccnc1N(C)S(C)(=O)=O | Homo sapiens | CHEMBL5321354 | single protein format |
| CHEMBL5433267 |  |
IC50 | = | 36.0 | nM | 451.56 | CC(C)c1ccc2[nH]c(-c3nccc(NCc4cccnc4N(C)S(C)(=O)=O)n3)nc2c1 | Homo sapiens | CHEMBL5321354 | single protein format |
| CHEMBL4468747 |  |
IC50 | = | 36.0 | nM | 472.54 | CCc1cc2c(cc1-c1cccc(S(=O)(=O)F)c1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O | Homo sapiens | CHEMBL4351071 | single protein format |
| CHEMBL426445 |  |
IC50 | = | 40.0 | nM | 388.47 | O=C(O)c1ccc2cc3nc(-c4cccs4)c(-c4cccs4)nc3cc2c1 | Homo sapiens | CHEMBL3365346 | single protein format |
| CHEMBL5277845 |  |
IC50 | < | 50.0 | nM | 489.57 | CN(c1ncccc1CNc1cnc(-c2nc3cc(-c4cnn(C)c4)ccc3[nH]2)nc1)S(C)(=O)=O | Homo sapiens | CHEMBL5260445 | single protein format |
| CHEMBL5270173 |  |
IC50 | < | 50.0 | nM | 445.46 | CN(c1ncccc1CNc1cnc(-c2nc3cc(F)cc(F)c3[nH]2)nc1)S(C)(=O)=O | Homo sapiens | CHEMBL5260445 | single protein format |
| CHEMBL5268208 |  |
IC50 | < | 50.0 | nM | 461.91 | CN(c1ncccc1CNc1cnc(-c2nc3cc(Cl)cc(F)c3[nH]2)nc1)S(C)(=O)=O | Homo sapiens | CHEMBL5260445 | single protein format |