Q96S37 | S22AC_HUMAN | Solute carrier family 22 member 12 (SLC22A12)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF07690 | MFS_1 - Major Facilitator Superfamily | 147~484 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3688167 |  |
IC50 | = | 0.0 | nM | 422.8 | N#Cc1cc(Oc2cc(F)c(S(=O)(=O)Nc3ncccn3)cc2Cl)ccc1F | Homo sapiens | CHEMBL3706306 | assay format |
| CHEMBL3688197 |  |
IC50 | = | 1.0 | nM | 433.85 | N#Cc1cc(S(=O)(=O)Nc2ccc(F)cn2)ccc1Oc1ccc(CO)c(Cl)c1 | Homo sapiens | CHEMBL3853443 | cell-based format |
| CHEMBL4087516 |  |
IC50 | = | 2.0 | nM | 327.29 | N#Cc1ccc(-c2cnccc2NS(=O)(=O)C(F)(F)F)cc1 | Homo sapiens | CHEMBL4015147 | cell-based format |
| CHEMBL3688190 |  |
IC50 | = | 2.0 | nM | 427.82 | O=S(=O)(Nc1ccc(F)cn1)c1ccc(Oc2cnc(CO)c(Cl)c2)cc1F | Homo sapiens | CHEMBL3706306 | assay format |
| CHEMBL3688192 |  |
IC50 | = | 3.0 | nM | 463.28 | N#Cc1cc(S(=O)(=O)Nc2ccc(F)cn2)ccc1Oc1cc(Cl)c(C#N)c(Cl)c1 | Homo sapiens | CHEMBL3706306 | assay format |
| CHEMBL5414132 |  |
IC50 | = | 4.0 | nM | 411.19 | N#Cc1c(Cl)cc(NS(=O)(=O)c2ccccc2OC(F)(F)F)cc1Cl | Homo sapiens | CHEMBL5357609 | single protein format |
| CHEMBL5399348 |  |
IC50 | = | 6.0 | nM | 376.74 | N#Cc1ccc(NS(=O)(=O)c2ccccc2OC(F)(F)F)cc1Cl | Homo sapiens | CHEMBL5357609 | single protein format |
| CHEMBL3971610 |  |
IC50 | = | 7.0 | nM | 352.34 | O=S(=O)(Nc1cnc2ccccc2c1)c1ccccc1C(F)(F)F | Homo sapiens | CHEMBL3853552 | cell-based format |
| CHEMBL3688188 |  |
IC50 | = | 8.0 | nM | 446.82 | N#Cc1cc(S(=O)(=O)Nc2ccc(F)cn2)ccc1Oc1cc(F)c(C#N)c(Cl)c1 | Homo sapiens | CHEMBL3706306 | assay format |
| CHEMBL4088988 |  |
IC50 | = | 10.0 | nM | 377.35 | N#Cc1ccc(-c2cnccc2NS(=O)(=O)C(F)(F)F)c2ccccc12 | Homo sapiens | CHEMBL4015147 | cell-based format |
| CHEMBL3692018 |  |
IC50 | = | 10.0 | nM | 363.24 | Cc1nn(Cc2c(Cl)cccc2Cl)c2cc(CCC(=O)O)ccc12 | Homo sapiens | CHEMBL3705755 | cell-based format |
| CHEMBL3692028 |  |
IC50 | = | 10.0 | nM | 405.31 | Cc1nn(Cc2c(Cl)cccc2Cl)c2cc(Cc3n[nH]c(=S)o3)ccc12 | Homo sapiens | CHEMBL3705755 | cell-based format |
| CHEMBL3683287 |  |
IC50 | = | 12.0 | nM | 428.83 | N#Cc1ccc(Oc2ccc(S(=O)(=O)Nc3ccc(F)cn3)cc2C#N)cc1Cl | Homo sapiens | CHEMBL3853443 | cell-based format |
| CHEMBL3688185 |  |
IC50 | = | 12.0 | nM | 445.29 | N#Cc1ccc(Oc2ccc(S(=O)(=O)Nc3ccc(Cl)cn3)cc2C#N)cc1Cl | Homo sapiens | CHEMBL3706306 | assay format |
| CHEMBL3692025 |  |
IC50 | = | 13.0 | nM | 373.25 | Cc1nn(Cc2c(Cl)cccc2Cl)c2cc(Cc3nnn[nH]3)ccc12 | Homo sapiens | CHEMBL3705755 | cell-based format |
| CHEMBL3683365 |  |
IC50 | = | 13.0 | nM | 422.44 | Cc1cc(Oc2ccc(S(=O)(=O)Nc3ccc(F)cn3)cc2C#N)cc(C)c1C#N | Homo sapiens | CHEMBL3706306 | assay format |
| CHEMBL3691994 |  |
IC50 | = | 15.0 | nM | 348.23 | Cc1cn(Cc2c(Cl)cccc2Cl)c2cc(CC(=O)O)ccc12 | Homo sapiens | CHEMBL3705755 | cell-based format |
| CHEMBL3692056 |  |
IC50 | = | 15.0 | nM | 385.2 | Cc1nn(Cc2c(Cl)cccc2Cl)c2cc(C(F)(F)C(=O)O)ccc12 | Homo sapiens | CHEMBL3705755 | cell-based format |
| CHEMBL3683388 |  |
IC50 | = | 15.0 | nM | 428.83 | N#Cc1ccc(Oc2ccc(S(=O)(=O)Nc3cc(F)ccn3)cc2C#N)cc1Cl | Homo sapiens | CHEMBL3706306 | assay format |
| CHEMBL3692024 |  |
IC50 | = | 16.0 | nM | 377.27 | Cc1nn(Cc2c(Cl)cccc2Cl)c2cc(CCCC(=O)O)ccc12 | Homo sapiens | CHEMBL3705755 | cell-based format |