Q96RU2 | UBP28_HUMAN | Ubiquitin carboxyl-terminal hydrolase 28 (USP28)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00443 | UCH - Ubiquitin carboxyl-terminal hydrolase | 162~647 | |
| PF21909 | USP_UIM_N - Ubiquitin-specific protease UIM domain | 74~126 | |
| PF22566 | UBA_8 - UBA-like domain | 19~64 |
3D structures mapped by conservation among orthologs
[ Domain: "RuvA-C, UBA, CRAL/TRIO-N, HBS1" // UBA_4 ]
[ Domain: "Cysteine proteinases" // UCH ]
[ Domain: "UIM domain" // UIM_like ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5401467 |  |
IC50 | = | 40.0 | nM | 461.37 | CS(=O)(=O)c1ccc(C(=O)Nc2ccc(Cl)c(-c3ccc4c(c3)CNC4)c2)c(Cl)c1 | Homo sapiens | CHEMBL5326702 | assay format |
| CHEMBL5431014 |  |
IC50 | = | 100.0 | nM | 475.4 | CS(=O)(=O)c1ccc(C(=O)Nc2ccc(Cl)c(-c3ccc4c(c3)CCNC4)c2)c(Cl)c1 | Homo sapiens | CHEMBL5326702 | assay format |
| CHEMBL5398929 |  |
IC50 | = | 110.0 | nM | 447.61 | Cc1ccc2c(N)c(C(=O)N[C@H]3CCc4cc(N5CC6CCC(C5)N6)ccc4C3)sc2n1 | Homo sapiens | CHEMBL5326702 | assay format |
| CHEMBL5402874 |  |
IC50 | = | 150.0 | nM | 449.36 | CS(=O)(=O)c1ccc(C(=O)Nc2ccc(Cl)c(-c3cccc(CN)c3)c2)c(Cl)c1 | Homo sapiens | CHEMBL5326702 | assay format |
| CHEMBL4515457 |  |
IC50 | < | 200.0 | nM | 471.58 | Cc1ccc2c(N)c(C(=O)NC[C@H](C)c3cc(F)c(N4CC5CCC(C4)N5)cc3F)sc2n1 | Homo sapiens | CHEMBL4477145 | single protein format |
| CHEMBL4556023 |  |
IC50 | < | 200.0 | nM | 437.61 | Cc1ccc2c(N)c(C(=O)NCCc3ccc(N4CCN[C@H](C(C)C)C4)cc3)sc2n1 | Homo sapiens | CHEMBL4477145 | single protein format |
| CHEMBL4528591 |  |
IC50 | < | 200.0 | nM | 409.56 | Cc1ccc2c(N)c(C(=O)NCCc3ccc(N4CCN[C@H](C)C4)cc3)sc2n1 | Homo sapiens | CHEMBL4477145 | single protein format |
| CHEMBL4573512 |  |
IC50 | < | 200.0 | nM | 409.56 | Cc1ccc2c(N)c(C(=O)NCCc3ccc(N4CCNC[C@@H]4C)cc3)sc2n1 | Homo sapiens | CHEMBL4477145 | single protein format |
| CHEMBL4579733 |  |
IC50 | < | 200.0 | nM | 409.56 | Cc1ccc2c(N)c(C(=O)NCCc3ccc(N4CCNC[C@H]4C)cc3)sc2n1 | Homo sapiens | CHEMBL4477145 | single protein format |
| CHEMBL4583493 |  |
IC50 | < | 200.0 | nM | 407.54 | Cc1ccc2c(N)c(C(=O)NCCc3ccc(N4C[C@H]5C[C@@H]4CN5)cc3)sc2n1 | Homo sapiens | CHEMBL4477145 | single protein format |
| CHEMBL4513784 |  |
IC50 | < | 200.0 | nM | 407.54 | Cc1ccc2c(N)c(C(=O)NCCc3ccc(N4C[C@@H]5C[C@H]4CN5)cc3)sc2n1 | Homo sapiens | CHEMBL4477145 | single protein format |
| CHEMBL4536782 |  |
IC50 | < | 200.0 | nM | 449.62 | Cc1ccc2c(N)c(C(=O)NCCc3ccc(N4CCC5(CCCNC5)C4)cc3)sc2n1 | Homo sapiens | CHEMBL4477145 | single protein format |
| CHEMBL4514423 |  |
IC50 | < | 200.0 | nM | 432.55 | Cc1ccc2c(N)c(C(=O)NCCc3ccc(N4CCn5cncc5C4)cc3)sc2n1 | Homo sapiens | CHEMBL4477145 | single protein format |
| CHEMBL4520844 |  |
IC50 | < | 200.0 | nM | 414.51 | Nc1nc2sc(C(=O)NCCc3ccc(N4CCNCC4)cc3)c(N)c2cc1F | Homo sapiens | CHEMBL4477145 | single protein format |
| CHEMBL4529940 |  |
IC50 | < | 200.0 | nM | 421.57 | Nc1c(C(=O)NCCc2ccc(N3CCNCC3)cc2)sc2nc(C3CC3)ccc12 | Homo sapiens | CHEMBL4477145 | single protein format |
| CHEMBL4558639 |  |
IC50 | < | 200.0 | nM | 430.52 | Cc1ccc2c(N)c(C(=O)NCCc3cc(F)c(C4CCNCC4)cc3F)sc2n1 | Homo sapiens | CHEMBL4477145 | single protein format |
| CHEMBL4589695 |  |
IC50 | < | 200.0 | nM | 489.57 | Cc1nc2sc(C(=O)NC[C@@H](C)c3cc(F)c(N4CC5CCC(C4)N5)cc3F)c(N)c2cc1F | Homo sapiens | CHEMBL4477145 | single protein format |
| CHEMBL4564243 |  |
IC50 | < | 200.0 | nM | 421.57 | Cc1ccc2c(N)c(C(=O)NCCc3ccc(N4CC5(CCCN5)C4)cc3)sc2n1 | Homo sapiens | CHEMBL4477145 | single protein format |
| CHEMBL4527283 |  |
IC50 | < | 200.0 | nM | 494.01 | Cc1ccc2c(N)c(C(=O)NCCc3cc(F)c(N4C[C@H]5CCN[C@H]5C4)cc3F)sc2n1.Cl | Homo sapiens | CHEMBL4477145 | single protein format |
| CHEMBL4543530 |  |
IC50 | < | 200.0 | nM | 494.01 | Cc1ccc2c(N)c(C(=O)NCCc3cc(F)c(N4C[C@@H]5CCN[C@@H]5C4)cc3F)sc2n1.Cl | Homo sapiens | CHEMBL4477145 | single protein format |