Q96RR4 | KKCC2_HUMAN | Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 165~446 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5421767 |  |
IC50 | = | 1.4 | nM | 336.39 | CCOc1ccc2c(-c3ccc(C(=O)O)c(C(C)C)c3)ncnc2c1 | Homo sapiens | CHEMBL5377217 | cell-based format |
| CHEMBL5439578 |  |
IC50 | = | 2.5 | nM | 380.42 | CCOc1cc(F)c2c(-c3ccc(C(=O)O)c(C4CCCC4)c3)ncnc2c1 | Homo sapiens | CHEMBL5377217 | cell-based format |
| CHEMBL558642 |  |
IC50 | = | 3.0 | nM | 382.46 | O=C(O)c1ccc(-c2c[nH]c3ncc(-c4ccccc4)cc23)cc1C1CCCC1 | Homo sapiens | CHEMBL4827571 | single protein format |
| CHEMBL5431962 |  |
IC50 | = | 4.0 | nM | 354.38 | CCOc1cc(F)c2c(-c3ccc(C(=O)O)c(C(C)C)c3)ncnc2c1 | Homo sapiens | CHEMBL5377217 | cell-based format |
| CHEMBL4875005 |  |
IC50 | = | 5.0 | nM | 399.52 | O=C(O)c1ccc(-c2csc3ncc(-c4ccccc4)cc23)cc1C1CCCC1 | Homo sapiens | CHEMBL4827571 | single protein format |
| CHEMBL5426746 |  |
IC50 | = | 7.0 | nM | 362.43 | CCOc1ccc2c(-c3ccc(C(=O)O)c(C4CCCC4)c3)ncnc2c1 | Homo sapiens | CHEMBL5377217 | cell-based format |
| CHEMBL5396413 |  |
IC50 | = | 7.0 | nM | 380.42 | CCOc1cc2ncnc(-c3ccc(C(=O)O)c(C4CCCC4)c3)c2cc1F | Homo sapiens | CHEMBL5377217 | cell-based format |
| CHEMBL265470 |  |
IC50 | = | 10.0 | nM | 374.35 | CC(=O)O.O=C(O)c1ccc2c3c1cccc3c(=O)n1c3ccccc3nc21 | Homo sapiens | CHEMBL1051267 | single protein format |
| CHEMBL4849143 |  |
IC50 | = | 12.0 | nM | 394.47 | O=C(O)c1ccc(-c2ncnc3ccc(-c4ccccc4)cc23)cc1C1CCCC1 | Homo sapiens | CHEMBL4827571 | single protein format |
| CHEMBL4852523 |  |
IC50 | = | 13.0 | nM | 317.39 | O=C(O)c1ccc(-c2ccnc3ccccc23)cc1C1CCCC1 | Homo sapiens | CHEMBL4827571 | single protein format |
| CHEMBL4876404 |  |
IC50 | = | 21.0 | nM | 268.32 | O=C(O)c1ccc(-c2ccncn2)cc1C1CCCC1 | Homo sapiens | CHEMBL4827571 | single protein format |
| CHEMBL4877552 |  |
IC50 | = | 21.0 | nM | 383.45 | O=C(O)c1ccc(-c2cnn3ccc(-c4ccccc4)nc23)cc1C1CCCC1 | Homo sapiens | CHEMBL4827571 | single protein format |
| CHEMBL4870467 |  |
IC50 | = | 23.0 | nM | 383.45 | O=C(O)c1ccc(-c2ccnc3[nH]c(-c4ccccc4)nc23)cc1C1CCCC1 | Homo sapiens | CHEMBL4827571 | single protein format |
| CHEMBL4862562 |  |
IC50 | = | 24.0 | nM | 324.4 | O=C(O)c1ccc(-c2ncnc3ccsc23)cc1C1CCCC1 | Homo sapiens | CHEMBL4827571 | single protein format |
| CHEMBL4125686 |  |
IC50 | = | 26.0 | nM | 306.37 | O=C(O)c1ccc(-c2c[nH]c3ncccc23)cc1C1CCCC1 | Homo sapiens | CHEMBL4827571 | single protein format |
| CHEMBL4745471 |  |
IC50 | = | 30.0 | nM | 397.47 | Cc1cccc(-c2cnc3occ(-c4ccc(C(=O)O)c(C5CCCC5)c4)c3c2)c1 | Homo sapiens | CHEMBL5210471 | single protein format |
| CHEMBL4853274 |  |
IC50 | = | 31.0 | nM | 324.4 | O=C(O)c1ccc(-c2ncnc3sccc23)cc1C1CCCC1 | Homo sapiens | CHEMBL4827571 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 33.6 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328339 | single protein format |
| CHEMBL4851925 |  |
IC50 | = | 44.0 | nM | 306.37 | O=C(O)c1ccc(-c2cnn3ccccc23)cc1C1CCCC1 | Homo sapiens | CHEMBL4827571 | single protein format |
| CHEMBL5397685 |  |
IC50 | = | 50.0 | nM | 354.38 | CCOc1cc2ncnc(-c3ccc(C(=O)O)c(C(C)C)c3)c2cc1F | Homo sapiens | CHEMBL5377217 | cell-based format |