Q96RI0 | PAR4_HUMAN | Proteinase-activated receptor 4 (F2RL3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 95~340 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3715848 |  |
IC50 | = | 0.0043 | nM | 490.57 | COc1cc(OCc2csc(-c3ccccc3)n2)c2cc(-c3cn4nc(OC)sc4n3)oc2c1 | Homo sapiens | CHEMBL3863832 | single protein format |
| CHEMBL3931873 |  |
IC50 | = | 1.69 | nM | 271.3 | COc1nn2cc(-c3cc4ccccc4o3)nc2s1 | Homo sapiens | CHEMBL3863832 | single protein format |
| CHEMBL3717891 |  |
IC50 | = | 2.1 | nM | 575.67 | COc1cc(OCc2nc(-c3ccc(C(=O)N(C)C)cc3)sc2C)c2cc(-c3cn4nc(OC)sc4n3)oc2c1 | Homo sapiens | CHEMBL4733441 | cell-free format |
| CHEMBL3716726 |  |
IC50 | = | 7.3 | nM | 513.6 | COc1cc(OCc2nc(N3CCOCC3)sc2C)c2cc(-c3cn4nc(OC)sc4n3)oc2c1 | Homo sapiens | CHEMBL4733441 | cell-free format |
| CHEMBL3728620 |  |
IC50 | = | 8.0 | nM | 513.58 | COc1cc(OCc2cccc(OCc3ccccc3)c2)c2cc(-c3cn4nc(OC)sc4n3)oc2c1 | Homo sapiens | CHEMBL4407126 | assay format |
| CHEMBL3933579 |  |
IC50 | = | 20.0 | nM | 368.34 | COc1nn2cc(-c3cc4cc(OC(F)(F)F)ccc4n3C)nc2s1 | Homo sapiens | CHEMBL3863813 | assay format |
| CHEMBL3909608 |  |
IC50 | = | 28.5 | nM | 300.17 | COc1nn2cc(-c3ccc(Cl)c(Cl)c3)nc2s1 | Homo sapiens | CHEMBL3863813 | assay format |
| CHEMBL3950308 |  |
IC50 | = | 36.3 | nM | 299.28 | COc1nn2cc(-c3cccc(C(F)(F)F)c3)nc2s1 | Homo sapiens | CHEMBL3863813 | assay format |
| CHEMBL3927486 |  |
IC50 | = | 52.3 | nM | 367.27 | COc1nn2cc(-c3cc(C(F)(F)F)cc(C(F)(F)F)c3)nc2s1 | Homo sapiens | CHEMBL3863813 | assay format |
| CHEMBL3922644 |  |
IC50 | = | 57.2 | nM | 245.31 | COc1nn2cc(-c3ccc(C)cc3)nc2s1 | Homo sapiens | CHEMBL3863813 | assay format |
| CHEMBL3334887 |  |
IC50 | = | 66.0 | nM | 355.44 | CCOC(=O)c1ccc(-c2cn(Cc3ccccc3)c3ccccc23)cc1 | Homo sapiens | CHEMBL3390699 | assay format |
| CHEMBL3902806 |  |
IC50 | = | 68.8 | nM | 317.27 | COc1nn2cc(-c3ccc(F)c(C(F)(F)F)c3)nc2s1 | Homo sapiens | CHEMBL3863813 | assay format |
| CHEMBL3890362 |  |
IC50 | = | 72.8 | nM | 265.73 | COc1nn2cc(-c3cccc(Cl)c3)nc2s1 | Homo sapiens | CHEMBL3863813 | assay format |
| CHEMBL3728724 |  |
IC50 | = | 74.0 | nM | 331.35 | COc1cc(OC)c2cc(-c3cn4nc(OC)sc4n3)oc2c1 | Homo sapiens | CHEMBL4407126 | assay format |
| CHEMBL3973767 |  |
IC50 | = | 83.4 | nM | 297.29 | COc1nn2cc(-c3ccc(OC(F)F)cc3)nc2s1 | Homo sapiens | CHEMBL3863813 | assay format |
| CHEMBL3728462 |  |
IC50 | = | 120.0 | nM | 301.33 | COc1ccc2cc(-c3cn4nc(OC)sc4n3)oc2c1 | Homo sapiens | CHEMBL4407126 | assay format |
| CHEMBL125021 |  |
IC50 | = | 130.0 | nM | 356.43 | CCOC(=O)c1ccc(-c2nn(Cc3ccccc3)c3ccccc23)cc1 | Homo sapiens | CHEMBL3390699 | assay format |
| CHEMBL1609104 |  |
IC50 | = | 140.0 | nM | 282.3 | Cn1c(CO)c(-c2ccccc2)c2cc([N+](=O)[O-])ccc21 | Homo sapiens | CHEMBL3390699 | assay format |
| CHEMBL3912611 |  |
IC50 | = | 175.0 | nM | 267.26 | COc1nn2cc(-c3ccc(F)cc3F)nc2s1 | Homo sapiens | CHEMBL3863813 | assay format |
| CHEMBL4566669 |  |
IC50 | = | 180.0 | nM | 508.91 | COc1nn2cc(-c3c(CO)n(Cc4ccccc4Cl)c4ccc(OC(F)(F)F)cc34)nc2s1 | Homo sapiens | CHEMBL4479528 | assay format |