Q96Q15 | SMG1_HUMAN | Serine/threonine-protein kinase SMG1 (SMG1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00454 | PI3_PI4_kinase - Phosphatidylinositol 3- and 4-kinase | 2150~2426 | |
| PF02260 | FATC - FATC domain | 3631~3660 | |
| PF15785 | SMG1 - Serine/threonine-protein kinase smg-1 | 631~1241 | |
| PF17229 | SMG1_N - Serine/threonine-protein kinase SMG1 N-terminal | 32~140 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2158864 |  |
IC50 | < | 0.05 | nM | 524.01 | CNC(=O)Nc1ccc(-c2cc(-c3ccnc(Nc4ccc(Cl)c(S(=O)(=O)NC)c4)n3)ccn2)cc1 | Homo sapiens | CHEMBL2161543 | cell-based format |
| CHEMBL2158862 |  |
IC50 | < | 0.05 | nM | 503.59 | CNC(=O)Nc1ccc(-c2cc(-c3ccnc(Nc4ccc(C)c(S(=O)(=O)NC)c4)n3)ccn2)cc1 | Homo sapiens | CHEMBL2161543 | cell-based format |
| CHEMBL2158858 |  |
IC50 | < | 0.05 | nM | 475.53 | CNC(=O)Nc1ccc(-c2cc(-c3ccnc(Nc4cccc(S(N)(=O)=O)c4)n3)ccn2)cc1 | Homo sapiens | CHEMBL2161543 | cell-based format |
| CHEMBL2158860 |  |
IC50 | < | 0.05 | nM | 489.56 | CNC(=O)Nc1ccc(-c2cc(-c3ccnc(Nc4ccc(C)c(S(N)(=O)=O)c4)n3)ccn2)cc1 | Homo sapiens | CHEMBL2161543 | cell-based format |
| CHEMBL2158861 |  |
IC50 | < | 0.05 | nM | 517.62 | CNC(=O)Nc1ccc(-c2cc(-c3ccnc(Nc4ccc(C)c(S(=O)(=O)N(C)C)c4)n3)ccn2)cc1 | Homo sapiens | CHEMBL2161543 | cell-based format |
| CHEMBL2158865 |  |
IC50 | < | 0.05 | nM | 538.03 | CNC(=O)Nc1ccc(-c2cc(-c3ccnc(Nc4ccc(Cl)c(S(=O)(=O)N(C)C)c4)n3)ccn2)cc1 | Homo sapiens | CHEMBL2161543 | cell-based format |
| CHEMBL2158859 |  |
IC50 | = | 0.1 | nM | 489.56 | CNC(=O)Nc1ccc(-c2cc(-c3ccnc(Nc4cccc(S(=O)(=O)NC)c4)n3)ccn2)cc1 | Homo sapiens | CHEMBL2161543 | cell-based format |
| CHEMBL2158866 |  |
IC50 | = | 0.11 | nM | 566.09 | CCN(CC)S(=O)(=O)c1cc(Nc2nccc(-c3ccnc(-c4ccc(NC(=O)NC)cc4)c3)n2)ccc1Cl | Homo sapiens | CHEMBL2161543 | cell-based format |
| CHEMBL2158863 |  |
IC50 | = | 0.2 | nM | 545.67 | CCN(CC)S(=O)(=O)c1cc(Nc2nccc(-c3ccnc(-c4ccc(NC(=O)NC)cc4)c3)n2)ccc1C | Homo sapiens | CHEMBL2161543 | cell-based format |
| CHEMBL2158011 |  |
IC50 | = | 0.2 | nM | 531.64 | CCN(CC)S(=O)(=O)c1cccc(Nc2nccc(-c3ccnc(-c4ccc(NC(=O)NC)cc4)c3)n2)c1 | Homo sapiens | CHEMBL2161543 | cell-based format |
| CHEMBL2158853 |  |
IC50 | = | 3.0 | nM | 398.49 | CCN(CC)c1cc(-c2ccnc(Nc3cccc(S(N)(=O)=O)c3)n2)ccn1 | Homo sapiens | CHEMBL2161543 | cell-based format |
| CHEMBL2158857 |  |
IC50 | = | 3.0 | nM | 410.5 | NS(=O)(=O)c1cccc(Nc2nccc(-c3ccnc(N4CCCCC4)c3)n2)c1 | Homo sapiens | CHEMBL2161543 | cell-based format |
| CHEMBL2158855 |  |
IC50 | = | 6.0 | nM | 438.51 | NS(=O)(=O)c1cccc(Nc2nccc(-c3ccnc(N4CC5CCC(C4)O5)c3)n2)c1 | Homo sapiens | CHEMBL2161543 | cell-based format |
| CHEMBL2158845 |  |
IC50 | = | 11.0 | nM | 412.48 | NS(=O)(=O)c1cccc(Nc2nccc(-c3ccnc(N4CCOCC4)c3)n2)c1 | Homo sapiens | CHEMBL2161543 | cell-based format |
| CHEMBL2158843 |  |
IC50 | = | 22.0 | nM | 400.46 | NS(=O)(=O)c1cccc(Nc2nccc(-c3ccnc(NCCCO)c3)n2)c1 | Homo sapiens | CHEMBL2161543 | cell-based format |
| CHEMBL2158854 |  |
IC50 | = | 25.0 | nM | 438.51 | NS(=O)(=O)c1cccc(Nc2nccc(-c3ccnc(N4C5CCC4COC5)c3)n2)c1 | Homo sapiens | CHEMBL2161543 | cell-based format |
| CHEMBL2158851 |  |
IC50 | = | 80.0 | nM | 358.41 | N#Cc1cccc(Nc2nccc(-c3ccnc(N4CCOCC4)c3)n2)c1 | Homo sapiens | CHEMBL2161543 | cell-based format |
| CHEMBL300389 |  |
IC50 | = | 110.0 | nM | 355.83 | OCCCNc1cc(-c2ccnc(Nc3cccc(Cl)c3)n2)ccn1 | Homo sapiens | CHEMBL2161543 | cell-based format |
| CHEMBL2158849 |  |
IC50 | = | 250.0 | nM | 401.39 | FC(F)(F)c1cccc(Nc2nccc(-c3ccnc(N4CCOCC4)c3)n2)c1 | Homo sapiens | CHEMBL2161543 | cell-based format |
| CHEMBL2158844 |  |
IC50 | = | 280.0 | nM | 367.84 | Clc1cccc(Nc2nccc(-c3ccnc(N4CCOCC4)c3)n2)c1 | Homo sapiens | CHEMBL2161543 | cell-based format |