Q96PY6 | NEK1_HUMAN | Serine/threonine-protein kinase Nek1 (NEK1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 4~257 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3667261 |  |
IC50 | = | 0.43 | nM | 350.44 | CC(C)(N)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 | Homo sapiens | CHEMBL3705860 | single protein format |
| CHEMBL3667249 |  |
IC50 | = | 0.5 | nM | 354.41 | NCCc1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1F | Homo sapiens | CHEMBL3705860 | single protein format |
| CHEMBL3667248 |  |
IC50 | = | 0.54 | nM | 336.42 | C[C@@H](N)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 | Homo sapiens | CHEMBL3705860 | single protein format |
| CHEMBL3667234 |  |
IC50 | = | 0.57 | nM | 437.54 | NCC1CCN(Cc2ccc(-c3c(O)ccc4[nH]c(=O)c5sccc5c34)cc2F)CC1 | Homo sapiens | CHEMBL3705860 | single protein format |
| CHEMBL3667204 |  |
IC50 | = | 0.63 | nM | 322.39 | NCc1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 | Homo sapiens | CHEMBL3705860 | single protein format |
| CHEMBL3672289 |  |
IC50 | = | 0.64 | nM | 350.44 | C[C@@H](CN)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 | Homo sapiens | CHEMBL3705860 | single protein format |
| CHEMBL3667250 |  |
IC50 | = | 0.67 | nM | 364.47 | CC(C)(CN)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 | Homo sapiens | CHEMBL3705860 | single protein format |
| CHEMBL3667224 |  |
IC50 | = | 0.73 | nM | 336.42 | CC(N)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 | Homo sapiens | CHEMBL3705860 | single protein format |
| CHEMBL3667246 |  |
IC50 | = | 0.74 | nM | 350.44 | NCCCc1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 | Homo sapiens | CHEMBL3705860 | single protein format |
| CHEMBL3672360 |  |
IC50 | = | 0.74 | nM | 364.47 | CCC(CN)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 | Homo sapiens | CHEMBL3705860 | single protein format |
| CHEMBL3667207 |  |
IC50 | = | 0.78 | nM | 298.37 | O=c1[nH]c2ccc(O)c(C3=CCNCC3)c2c2ccsc12 | Homo sapiens | CHEMBL3705860 | single protein format |
| CHEMBL3667241 |  |
IC50 | = | 0.78 | nM | 328.42 | NCc1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)s1 | Homo sapiens | CHEMBL3705860 | single protein format |
| CHEMBL3667233 |  |
IC50 | = | 0.81 | nM | 336.42 | C[C@H](N)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 | Homo sapiens | CHEMBL3705860 | single protein format |
| CHEMBL3672235 |  |
IC50 | = | 0.82 | nM | 350.44 | CCC(N)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 | Homo sapiens | CHEMBL3705860 | single protein format |
| CHEMBL3672269 |  |
IC50 | = | 0.88 | nM | 350.44 | CC[C@H](N)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 | Homo sapiens | CHEMBL3705860 | single protein format |
| CHEMBL3667245 |  |
IC50 | = | 0.88 | nM | 364.47 | C[C@H](c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1)N(C)C | Homo sapiens | CHEMBL3705860 | single protein format |
| CHEMBL3667219 |  |
IC50 | = | 0.9 | nM | 336.42 | CNCc1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1 | Homo sapiens | CHEMBL3705860 | single protein format |
| CHEMBL3672246 |  |
IC50 | = | 0.92 | nM | 354.41 | CC(N)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1F | Homo sapiens | CHEMBL3705860 | single protein format |
| CHEMBL3667251 |  |
IC50 | = | 0.97 | nM | 410.47 | O=c1[nH]c2ccc(O)c(-c3ccc(CN4CCC(O)C4)c(F)c3)c2c2ccsc12 | Homo sapiens | CHEMBL3705860 | single protein format |
| CHEMBL3672339 |  |
IC50 | = | 1.0 | nM | 382.46 | CC(C)(CN)c1ccc(-c2c(O)ccc3[nH]c(=O)c4sccc4c23)cc1F | Homo sapiens | CHEMBL3705860 | single protein format |