Q96PN6 | ADCYA_HUMAN | Adenylate cyclase type 10 (ADCY10)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00211 | Guanylate_cyc - Adenylate and Guanylate cyclase catalytic domain | 43~207 | |
| PF00211 | Guanylate_cyc - Adenylate and Guanylate cyclase catalytic domain | 291~418 |
3D structures mapped by conservation among orthologs
[ Domain: "Adenylyl and guanylyl cyclase catalytic domain-like" // Guanylate_cyc ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5220685 |  |
IC50 | = | 1.0 | nM | 522.94 | COC(=O)[C@H]1COCCN1CCOc1ccccc1Cc1cn(C(F)F)nc1-c1cc(Cl)nc(N)n1 | Homo sapiens | CHEMBL5218088 | single protein format |
| CHEMBL5218878 |  |
IC50 | = | 2.1 | nM | 477.9 | Nc1nc(Cl)cc(-c2nn(C(F)F)cc2Cc2ccccc2OCCN2CCNC(=O)C2)n1 | Homo sapiens | CHEMBL5218088 | single protein format |
| CHEMBL5218552 |  |
IC50 | = | 2.2 | nM | 522.94 | COC(=O)[C@@H]1COCCN1CCOc1ccccc1Cc1cn(C(F)F)nc1-c1cc(Cl)nc(N)n1 | Homo sapiens | CHEMBL5218088 | single protein format |
| CHEMBL5218615 |  |
IC50 | = | 2.4 | nM | 512.97 | Nc1nc(Cl)cc(-c2nn(C(F)F)cc2Cc2ccccc2OCCN2CCS(=O)(=O)CC2)n1 | Homo sapiens | CHEMBL5218088 | single protein format |
| CHEMBL5219579 |  |
IC50 | = | 3.3 | nM | 494.93 | Nc1nc(Cl)cc(-c2nn(C(F)F)cc2Cc2ccccc2OCCN2CCO[C@@H](CO)C2)n1 | Homo sapiens | CHEMBL5218088 | single protein format |
| CHEMBL5219830 |  |
IC50 | = | 3.33 | nM | 494.93 | Nc1nc(Cl)cc(-c2nn(C(F)F)cc2Cc2ccccc2OCCN2CCOC[C@H]2CO)n1 | Homo sapiens | CHEMBL5218088 | single protein format |
| CHEMBL5218698 |  |
IC50 | = | 3.9 | nM | 464.9 | Nc1nc(Cl)cc(-c2nn(C(F)F)cc2Cc2ccccc2OCCN2CCOCC2)n1 | Homo sapiens | CHEMBL5218088 | single protein format |
| CHEMBL5218702 |  |
IC50 | = | 4.0 | nM | 492.96 | CC1(O)CCN(CCOc2ccccc2Cc2cn(C(F)F)nc2-c2cc(Cl)nc(N)n2)CC1 | Homo sapiens | CHEMBL5218088 | single protein format |
| CHEMBL5220647 |  |
IC50 | = | 4.6 | nM | 494.93 | Nc1nc(Cl)cc(-c2nn(C(F)F)cc2Cc2ccccc2OCCN2CCOC[C@@H]2CO)n1 | Homo sapiens | CHEMBL5218088 | single protein format |
| CHEMBL5219443 |  |
IC50 | = | 5.5 | nM | 494.93 | Nc1nc(Cl)cc(-c2nn(C(F)F)cc2Cc2ccccc2OCCN2CCO[C@H](CO)C2)n1 | Homo sapiens | CHEMBL5218088 | single protein format |
| CHEMBL5220895 |  |
IC50 | = | 6.7 | nM | 440.94 | Cn1cc(Cc2ccccc2OCCN2CC3CC(C2)O3)c(-c2cc(Cl)nc(N)n2)n1 | Homo sapiens | CHEMBL5218088 | single protein format |
| CHEMBL5220347 |  |
IC50 | = | 7.8 | nM | 440.94 | Cn1cc(Cc2ccccc2OCCN2CC3(COC3)C2)c(-c2cc(Cl)nc(N)n2)n1 | Homo sapiens | CHEMBL5218088 | single protein format |
| CHEMBL5220723 |  |
IC50 | = | 12.3 | nM | 428.92 | Cn1cc(Cc2ccccc2OCCN2CCOCC2)c(-c2cc(Cl)nc(N)n2)n1 | Homo sapiens | CHEMBL5218088 | single protein format |
| CHEMBL5219922 |  |
IC50 | = | 16.9 | nM | 441.92 | Cn1cc(Cc2ccccc2OCCN2CCNC(=O)C2)c(-c2cc(Cl)nc(N)n2)n1 | Homo sapiens | CHEMBL5218088 | single protein format |
| CHEMBL5219530 |  |
IC50 | = | 21.0 | nM | 357.8 | COC(=O)c1ccccc1Cc1cn(C)nc1-c1cc(Cl)nc(N)n1 | Homo sapiens | CHEMBL5218088 | single protein format |
| CHEMBL5220632 |  |
IC50 | = | 24.2 | nM | 478.89 | Nc1nc(Cl)cc(-c2nn(C(F)F)cc2Cc2ccccc2OCC(=O)N2CCOCC2)n1 | Homo sapiens | CHEMBL5218088 | single protein format |
| CHEMBL4878379 |  |
IC50 | = | 28.0 | nM | 357.8 | COC(=O)c1c(Cc2ccccc2)c(-c2cc(Cl)nc(N)n2)nn1C | Homo sapiens | CHEMBL4839263 | single protein format |
| CHEMBL5221008 |  |
IC50 | = | 64.0 | nM | 334.21 | Cn1cc(Cc2ccccc2Cl)c(-c2cc(Cl)nc(N)n2)n1 | Homo sapiens | CHEMBL5218088 | single protein format |
| CHEMBL5220075 |  |
IC50 | = | 67.0 | nM | 329.79 | COc1ccccc1Cc1cn(C)nc1-c1cc(Cl)nc(N)n1 | Homo sapiens | CHEMBL5218088 | single protein format |
| CHEMBL4848035 |  |
IC50 | = | 74.0 | nM | 319.82 | Cc1c(Cc2cccs2)c(-c2cc(Cl)nc(N)n2)nn1C | Homo sapiens | CHEMBL4839263 | single protein format |